Human Gene CAMK2D (uc003ibm.2) Description and Page Index
Description: Homo sapiens calcium/calmodulin-dependent protein kinase II delta (CAMK2D), transcript variant 6, mRNA. RefSeq Summary (NM_172114): The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008]. Transcript (Including UTRs) Position: hg19 chr4:114,378,344-114,683,083 Size: 304,740 Total Exon Count: 18 Strand: - Coding Region Position: hg19 chr4:114,378,487-114,682,224 Size: 303,738 Coding Exon Count: 18
E-Selectin Andrew D Paterson et al. Arteriosclerosis, thrombosis, and vascular biology 2009, Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin., Arteriosclerosis, thrombosis, and vascular biology.
ABO is a major locus for serum soluble E-selectin levels. We excluded population stratification, fine-mapped the association to sub-A alleles, and also document association with additional variation in the ABO region.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00069 - Protein kinase domain PF07714 - Protein tyrosine kinase PF08332 - Calcium/calmodulin dependent protein kinase II association domain PF13474 - SnoaL-like domain PF14534 - Domain of unknown function (DUF4440)
ModBase Predicted Comparative 3D Structure on Q13557-10
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK025368 - Homo sapiens cDNA: FLJ21715 fis, clone COL10287, highly similar to AF071569 Homo sapiens multifunctional calcium/calmodulin-dependent protein kinase II delta2 isoform mRNA. AK294517 - Homo sapiens cDNA FLJ53470 complete cds, highly similar to Calcium/calmodulin-dependent protein kinase type II delta chain (EC 220.127.116.11). AK055642 - Homo sapiens cDNA FLJ31080 fis, clone HSYRA2001615, highly similar to Calcium/calmodulin-dependent protein kinase type II delta chain (EC 18.104.22.168). AF071569 - Homo sapiens multifunctional calcium/calmodulin-dependent protein kinase II delta2 isoform mRNA, complete cds. AB209288 - Homo sapiens mRNA for calcium/calmodulin-dependent protein kinase II delta isoform 1 variant protein. BC032784 - Homo sapiens calcium/calmodulin-dependent protein kinase II delta, mRNA (cDNA clone MGC:44911 IMAGE:5178265), complete cds. AY987011 - Homo sapiens calcium/calmodulin-dependent protein kinase II delta mRNA, complete cds, alternatively spliced. EU176241 - Synthetic construct Homo sapiens clone IMAGE:100006427; FLH182803.01X; RZPDo839H07250D calcium/calmodulin-dependent protein kinase (CaM kinase) II delta (CAMK2D) gene, encodes complete protein. KJ896536 - Synthetic construct Homo sapiens clone ccsbBroadEn_05930 CAMK2D gene, encodes complete protein. KJ905159 - Synthetic construct Homo sapiens clone ccsbBroadEn_14565 CAMK2D gene, encodes complete protein. DQ895255 - Synthetic construct Homo sapiens clone IMAGE:100009715; FLH182796.01L; RZPDo839C05139D calcium/calmodulin-dependent protein kinase (CaM kinase) II delta (CAMK2D) gene, encodes complete protein. AB384909 - Synthetic construct DNA, clone: pF1KB4158, Homo sapiens CAMK2D gene for calcium/calmodulin-dependent protein kinase type II delta chain, complete cds, without stop codon, in Flexi system. U50361 - Human calcium, calmodulin-dependent protein kinase II delta mRNA, partial cds. U73738 - Human calcium/calmodulin-dependent protein kinase II delta E mRNA, partial cds. EF139846 - Homo sapiens clone 1-4 calcium/calmodulin-dependent protein kinase II splice variant (CAMK2D) mRNA, partial sequence; alternatively spliced. BC022558 - Homo sapiens calcium/calmodulin-dependent protein kinase II delta, mRNA (cDNA clone IMAGE:4794502), partial cds. AJ252239 - Homo sapiens partial mRNA for calcium/calmodulin dependent protein kinase II delta (CaMK II delta gene). JD065186 - Sequence 46210 from Patent EP1572962. JD124637 - Sequence 105661 from Patent EP1572962. JD075743 - Sequence 56767 from Patent EP1572962. JD336951 - Sequence 317975 from Patent EP1572962. JD222570 - Sequence 203594 from Patent EP1572962. JD174177 - Sequence 155201 from Patent EP1572962. JD203962 - Sequence 184986 from Patent EP1572962. JD140763 - Sequence 121787 from Patent EP1572962. JD142252 - Sequence 123276 from Patent EP1572962. JD399317 - Sequence 380341 from Patent EP1572962. JD193180 - Sequence 174204 from Patent EP1572962.