Human Gene ARHGAP10 (uc003ile.1) Description and Page Index
  Description: Homo sapiens Rho GTPase activating protein 10 (ARHGAP10), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr4:148,653,453-148,779,639 Size: 126,187 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr4:148,653,453-148,778,811 Size: 125,359 Coding Exon Count: 5 

Page IndexSequence and LinksGenetic AssociationsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr4:148,653,453-148,779,639)mRNA (may differ from genome)Protein (163 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ARHGAP10
CDC HuGE Published Literature: ARHGAP10
Positive Disease Associations: Blood Pressure , Body Height , Bone Density , Cholesterol , Electrocardiography , Exercise Test , Heart Rate , QT interval , Walking
Related Studies:
  1. Blood Pressure
    Daniel Levy et al. BMC medical genetics 2007, Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness., BMC medical genetics. [PubMed 17903302]
    These results of genome-wide association testing for blood pressure and arterial stiffness phenotypes in an unselected community-based sample of adults may aid in the identification of the genetic basis of hypertension and arterial disease, help identify high risk individuals, and guide novel therapies for hypertension. Additional studies are needed to replicate any associations identified in these analyses.
  2. Body Height
    Caroline S Fox et al. BMC medical genetics 2007, Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project., BMC medical genetics. [PubMed 17903300]
    Adiposity traits are associated with SNPs on the Affymetrix 100K SNP GeneChip. Replication of these initial findings is necessary. These data will serve as a resource for replication as more genes become identified with BMI and WC.
  3. Bone Density
    Douglas P Kiel et al. BMC medical genetics 2007, Genome-wide association with bone mass and geometry in the Framingham Heart Study., BMC medical genetics. [PubMed 17903296]
    The FHS 100K SNP project offers an unbiased genome-wide strategy to identify new candidate loci and to replicate previously suggested candidate genes for osteoporosis.
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 50.92 RPKM in Esophagus - Muscularis
Total median expression: 702.88 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -170.34828-0.206 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Descriptions from all associated GenBank mRNAs
  AB050785 - Homo sapiens mRNA for Graf2, complete cds.
BC128055 - Homo sapiens Rho GTPase activating protein 10, mRNA (cDNA clone MGC:125637 IMAGE:40027832), complete cds.
BC126899 - Homo sapiens Rho GTPase activating protein 10, mRNA (cDNA clone IMAGE:40027833), partial cds.
BC109029 - Homo sapiens Rho GTPase activating protein 10, mRNA (cDNA clone IMAGE:40027834), partial cds.
BC109030 - Homo sapiens Rho GTPase activating protein 10, mRNA (cDNA clone IMAGE:40027836), partial cds.
BC011920 - Homo sapiens Rho GTPase activating protein 10, mRNA (cDNA clone IMAGE:4310652), partial cds.
AK123785 - Homo sapiens cDNA FLJ41791 fis, clone NESOP2001694, moderately similar to H.sapiens graf gene.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa05100 - Bacterial invasion of epithelial cells

-  Other Names for This Gene
  Alternate Gene Symbols: AK123785
UCSC ID: uc003ile.1
RefSeq Accession: NM_024605

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: AK123785.1
exon count: 5CDS single in 3' UTR: no RNA size: 1558
ORF size: 492CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1030.00frame shift in genome: no % Coverage: 84.66
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 834# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.