Human Gene GLRX (uc003kln.4) Description and Page Index
Description: Homo sapiens glutaredoxin (thioltransferase) (GLRX), transcript variant 1, mRNA. RefSeq Summary (NM_002064): This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]. Transcript (Including UTRs) Position: hg19 chr5:95,149,553-95,158,577 Size: 9,025 Total Exon Count: 3 Strand: - Coding Region Position: hg19 chr5:95,152,217-95,158,366 Size: 6,150 Coding Exon Count: 2
ID:GLRX1_HUMAN DESCRIPTION: RecName: Full=Glutaredoxin-1; AltName: Full=Thioltransferase-1; Short=TTase-1; FUNCTION: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the glutaredoxin family. SIMILARITY: Contains 1 glutaredoxin domain. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/glrx/";
Genetic Association Studies of Complex Diseases and Disorders
cognitive trait Sarah E Harris , et al. BMC genetics 2007 8:43, A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition., BMC genetics 2007 8:43.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P35754
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0009055 electron carrier activity GO:0015035 protein disulfide oxidoreductase activity GO:0015038 glutathione disulfide oxidoreductase activity GO:0047485 protein N-terminus binding GO:0097573 glutathione oxidoreductase activity
Biological Process: GO:0015949 nucleobase-containing small molecule interconversion GO:0022900 electron transport chain GO:0045454 cell redox homeostasis GO:0045838 positive regulation of membrane potential GO:0055114 oxidation-reduction process GO:0080058 protein deglutathionylation GO:2000651 positive regulation of sodium ion transmembrane transporter activity