Human Gene CXXC5 (uc003let.2) Description and Page Index
  Description: Homo sapiens CXXC finger protein 5 (CXXC5), mRNA.
RefSeq Summary (NM_016463): The protein encoded by this gene is a retinoid-inducible nuclear protein containing a CXXC-type zinc finger motif. The encoded protein is involved in myelopoiesis, is required for DNA damage-induced p53 activation, regulates the differentiation of C2C12 myoblasts into myocytes, and negatively regulates cutaneous wound healing. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015].
Transcript (Including UTRs)
   Position: hg19 chr5:139,028,518-139,062,680 Size: 34,163 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr5:139,060,109-139,062,492 Size: 2,384 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr5:139,028,518-139,062,680)mRNA (may differ from genome)Protein (322 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
OMIMPubMedReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=CXXC-type zinc finger protein 5; Short=CF5; AltName: Full=Putative MAPK-activating protein PM08; AltName: Full=Putative NF-kappa-B-activating protein 102; AltName: Full=Retinoid-inducible nuclear factor; Short=RINF;
FUNCTION: May indirectly participate in activation of the NF- kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis.
SUBUNIT: Interacts with DVL1 (By similarity).
SUBCELLULAR LOCATION: Nucleus. Cytoplasm (By similarity). Note=Colocalizes with DVL1 in large bodies localized just outside the nuclear membrane (By similarity).
INDUCTION: By retinoic acid.
SIMILARITY: Contains 1 CXXC-type zinc finger.
SEQUENCE CAUTION: Sequence=AAF36115.1; Type=Frameshift; Positions=32, 102, 119, 250, 265; Sequence=AAH02490.3; Type=Erroneous initiation; Sequence=AAH06428.1; Type=Erroneous initiation; Sequence=AAH17439.2; Type=Erroneous initiation; Sequence=AAH24040.2; Type=Erroneous initiation; Sequence=AAH41013.2; Type=Erroneous initiation;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CXXC5
CDC HuGE Published Literature: CXXC5
Positive Disease Associations: Lipoproteins
Related Studies:
  1. Lipoproteins
    , , . [PubMed 0]
  2. Lipoproteins
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 78.56 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 842.87 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -117.40237-0.495 Picture PostScript Text
3' UTR -40.99188-0.218 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002857 - Znf_CXXC

Pfam Domains:
PF02008 - CXXC zinc finger domain

ModBase Predicted Comparative 3D Structure on Q7LFL8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

-  Descriptions from all associated GenBank mRNAs
  AK024338 - Homo sapiens cDNA FLJ14276 fis, clone PLACE1005128, highly similar to Rattus norvegicus CXXC finger 5 (Cxxc5), mRNA.
BC006428 - Homo sapiens CXXC finger 5, mRNA (cDNA clone MGC:12969 IMAGE:3343683), complete cds.
BC024040 - Homo sapiens CXXC finger 5, mRNA (cDNA clone MGC:13084 IMAGE:3925666), complete cds.
BC041013 - Homo sapiens CXXC finger 5, mRNA (cDNA clone MGC:13147 IMAGE:4139961), complete cds.
BC050046 - Homo sapiens, Similar to RIKEN cDNA 4930415K17 gene, clone IMAGE:4158283, mRNA.
BC017439 - Homo sapiens CXXC finger 5, mRNA (cDNA clone MGC:12958 IMAGE:2989328), complete cds.
AB097005 - Homo sapiens mRNA for putative NFkB activating protein, complete cds, clone: 102.
AB097032 - Homo sapiens mRNA for putative MAPK activating protein, complete cds, clone: PM08.
BC013025 - Homo sapiens cDNA clone IMAGE:3528660, **** WARNING: chimeric clone ****.
AK001782 - Homo sapiens cDNA FLJ10920 fis, clone OVARC1000384.
JD353351 - Sequence 334375 from Patent EP1572962.
JD259789 - Sequence 240813 from Patent EP1572962.
JD068732 - Sequence 49756 from Patent EP1572962.
JD343770 - Sequence 324794 from Patent EP1572962.
BC002490 - Homo sapiens CXXC finger 5, mRNA (cDNA clone MGC:915 IMAGE:3050465), complete cds.
JD475117 - Sequence 456141 from Patent EP1572962.
JD256470 - Sequence 237494 from Patent EP1572962.
AB463548 - Synthetic construct DNA, clone: pF1KB8184, Homo sapiens CXXC5 gene for CXXC finger 5, without stop codon, in Flexi system.
KJ893931 - Synthetic construct Homo sapiens clone ccsbBroadEn_03325 CXXC5 gene, encodes complete protein.
GQ379202 - Homo sapiens CXXC finger 5 protein (CF5) mRNA, complete cds.
AK314420 - Homo sapiens cDNA, FLJ95205.
JD222937 - Sequence 203961 from Patent EP1572962.
AY007103 - Homo sapiens clone TCCCIA00297 mRNA sequence.
JD114485 - Sequence 95509 from Patent EP1572962.
JD355461 - Sequence 336485 from Patent EP1572962.
JD497105 - Sequence 478129 from Patent EP1572962.
AF151029 - Homo sapiens HSPC195 mRNA, complete cds.
JD209775 - Sequence 190799 from Patent EP1572962.
JD074861 - Sequence 55885 from Patent EP1572962.
JD497943 - Sequence 478967 from Patent EP1572962.
JD543739 - Sequence 524763 from Patent EP1572962.
JD479779 - Sequence 460803 from Patent EP1572962.
JD458412 - Sequence 439436 from Patent EP1572962.
JD557056 - Sequence 538080 from Patent EP1572962.
DQ892589 - Synthetic construct clone IMAGE:100005219; FLH187823.01X; RZPDo839D06150D CXXC finger 5 (CXXC5) gene, encodes complete protein.
DQ895807 - Synthetic construct Homo sapiens clone IMAGE:100010267; FLH187819.01L; RZPDo839D06149D CXXC finger 5 (CXXC5) gene, encodes complete protein.
JD042954 - Sequence 23978 from Patent EP1572962.
JD563350 - Sequence 544374 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q7LFL8 (Reactome details) participates in the following event(s):

R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-8939211 ESR-mediated signaling
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: AK001782, B3KND0, C8CBA8, CXXC5_HUMAN, HSPC195, NM_016463, NP_057547, Q7LFL8, Q8TB79, Q9NV51, Q9P0S8, TCCCIA00297
UCSC ID: uc003let.2
RefSeq Accession: NM_016463
Protein: Q7LFL8 (aka CXXC5_HUMAN)
CCDS: CCDS43370.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: AK001782.1
exon count: 3CDS single in 3' UTR: no RNA size: 1637
ORF size: 969CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2123.00frame shift in genome: no % Coverage: 84.97
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.