Human Gene PRR7 (uc003mgu.2) Description and Page Index
  Description: Homo sapiens proline rich 7 (synaptic) (PRR7), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr5:176,873,796-176,883,287 Size: 9,492 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr5:176,882,069-176,883,122 Size: 1,054 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:176,873,796-176,883,287)mRNA (may differ from genome)Protein (274 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
OMIMPubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: PRR7_HUMAN
DESCRIPTION: RecName: Full=Proline-rich protein 7; AltName: Full=Synaptic proline-rich membrane protein;
SUBUNIT: Found in a postsynaptic membrane complex with DLG4 and GRIN1. Interacts with DLG4. Interacts preferentially to the PDZ3 domain of DLG4 and to lesser degree to PDZ2 but not to the PDZ1 (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type III membrane protein (Potential). Cell junction, synapse, postsynaptic cell membrane (By similarity). Note=Enriched in postsynaptic plasma membrane and postsynaptic densities (PSD). Accumulates in spines along with synapse maturation and colocalizes with DLG4 in a punctate pattern (By similarity).

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.82 RPKM in Brain - Nucleus accumbens (basal ganglia)
Total median expression: 144.91 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -259.60490-0.530 Picture PostScript Text
3' UTR -64.40165-0.390 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR021684 - Uncharacterised_WW-bd

ModBase Predicted Comparative 3D Structure on Q8TB68
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0002250 adaptive immune response
GO:0002376 immune system process

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030425 dendrite
GO:0042995 cell projection
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0048471 perinuclear region of cytoplasm


-  Descriptions from all associated GenBank mRNAs
  BC024233 - Homo sapiens proline rich 7 (synaptic), mRNA (cDNA clone MGC:27428 IMAGE:4697841), complete cds.
JD406284 - Sequence 387308 from Patent EP1572962.
BC004261 - Homo sapiens proline rich 7 (synaptic), mRNA (cDNA clone MGC:10772 IMAGE:3606982), complete cds.
BC021240 - Homo sapiens proline rich 7 (synaptic), mRNA (cDNA clone MGC:20448 IMAGE:3603954), complete cds.
JD344570 - Sequence 325594 from Patent EP1572962.
JD467322 - Sequence 448346 from Patent EP1572962.
JD145626 - Sequence 126650 from Patent EP1572962.
JD332849 - Sequence 313873 from Patent EP1572962.
JD478191 - Sequence 459215 from Patent EP1572962.
JD141974 - Sequence 122998 from Patent EP1572962.
BC033649 - Homo sapiens proline rich 7 (synaptic), mRNA (cDNA clone MGC:44943 IMAGE:5538503), complete cds.
AB587494 - Synthetic construct DNA, clone: pF1KB8735, Homo sapiens PRR7 gene for proline rich 7, without stop codon, in Flexi system.
EU831424 - Synthetic construct Homo sapiens clone HAIB:100066453; DKFZo008B1117 proline rich 7 (synaptic) protein (PRR7) gene, encodes complete protein.
EU831517 - Synthetic construct Homo sapiens clone HAIB:100066546; DKFZo004B1118 proline rich 7 (synaptic) protein (PRR7) gene, encodes complete protein.
CU676888 - Synthetic construct Homo sapiens gateway clone IMAGE:100023305 5' read PRR7 mRNA.
HQ448198 - Synthetic construct Homo sapiens clone IMAGE:100071595; CCSB006988_02 proline rich 7 (synaptic) (PRR7) gene, encodes complete protein.
KJ894825 - Synthetic construct Homo sapiens clone ccsbBroadEn_04219 PRR7 gene, encodes complete protein.
JD060159 - Sequence 41183 from Patent EP1572962.
JD291547 - Sequence 272571 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_030567, NP_085044, PRR7_HUMAN, Q8TB68, Q8WU53, Q9BTA7
UCSC ID: uc003mgu.2
RefSeq Accession: NM_030567
Protein: Q8TB68 (aka PRR7_HUMAN)
CCDS: CCDS4419.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_030567.4
exon count: 4CDS single in 3' UTR: no RNA size: 1543
ORF size: 825CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1549.00frame shift in genome: no % Coverage: 95.92
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.