Human Gene PDLIM7 (uc003mhe.1) Description and Page Index
  Description: Homo sapiens PDZ and LIM domain 7 (enigma) (PDLIM7), transcript variant 1, mRNA.
RefSeq Summary (NM_213636): The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr5:176,910,395-176,924,602 Size: 14,208 Total Exon Count: 13 Strand: -


Page IndexSequence and LinksMalaCardsCTDRNA-Seq ExpressionMicroarray Expression
Other SpeciesmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:176,910,395-176,924,602)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneNetwork
H-INVHGNCLynxOMIMPubMedStanford SOURCE
Wikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: PDLIM7
Diseases sorted by gene-association score: pleural empyema (8), dental pulp calcification (8), n syndrome (7), bare lymphocyte syndrome, type i (4), pharynx cancer (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 253.54 RPKM in Colon - Sigmoid
Total median expression: 2749.90 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK131426 - Homo sapiens cDNA FLJ16550 fis, clone PROST2009320.
AF345904 - Homo sapiens LIM mineralization protein 1 mRNA, complete cds.
AF345905 - Homo sapiens LIM mineralization protein 2 mRNA, complete cds.
AF345906 - Homo sapiens LIM mineralization protein 3 mRNA, complete cds.
BC001093 - Homo sapiens PDZ and LIM domain 7 (enigma), mRNA (cDNA clone MGC:3269 IMAGE:3506748), complete cds.
BC007648 - Homo sapiens PDZ and LIM domain 7 (enigma), mRNA (cDNA clone IMAGE:3538103), with apparent retained intron.
AF265209 - Homo sapiens ENIGMA protein mRNA, complete cds.
AK096826 - Homo sapiens cDNA FLJ39507 fis, clone PROST2017617, highly similar to Homo sapiens ENIGMA protein mRNA.
BC067806 - Homo sapiens PDZ and LIM domain 7 (enigma), mRNA (cDNA clone IMAGE:5287820).
JD319195 - Sequence 300219 from Patent EP1572962.
JD053852 - Sequence 34876 from Patent EP1572962.
JD115411 - Sequence 96435 from Patent EP1572962.
JD369927 - Sequence 350951 from Patent EP1572962.
JD123250 - Sequence 104274 from Patent EP1572962.
JD194459 - Sequence 175483 from Patent EP1572962.
JD055847 - Sequence 36871 from Patent EP1572962.
JD401306 - Sequence 382330 from Patent EP1572962.
JD077333 - Sequence 58357 from Patent EP1572962.
JD121393 - Sequence 102417 from Patent EP1572962.
KJ892731 - Synthetic construct Homo sapiens clone ccsbBroadEn_02125 PDLIM7 gene, encodes complete protein.
DQ892135 - Synthetic construct clone IMAGE:100004765; FLH183328.01X; RZPDo839B01142D PDZ and LIM domain 7 (enigma) (PDLIM7) gene, encodes complete protein.
DQ895329 - Synthetic construct Homo sapiens clone IMAGE:100009789; FLH183325.01L; RZPDo839B01141D PDZ and LIM domain 7 (enigma) (PDLIM7) gene, encodes complete protein.
AB528311 - Synthetic construct DNA, clone: pF1KE0786, Homo sapiens PDLIM7 gene for PDZ and LIM domain 7, without stop codon, in Flexi system.
BC084575 - Homo sapiens PDZ and LIM domain 7 (enigma), mRNA (cDNA clone MGC:99612 IMAGE:6729368), complete cds.
DQ291143 - Homo sapiens enigma-like mRNA, partial sequence.
CU674544 - Synthetic construct Homo sapiens gateway clone IMAGE:100017313 5' read PDLIM7 mRNA.
BC014521 - Homo sapiens PDZ and LIM domain 7 (enigma), mRNA (cDNA clone IMAGE:3690154), complete cds.
KJ892732 - Synthetic construct Homo sapiens clone ccsbBroadEn_02126 PDLIM7 gene, encodes complete protein.
KJ901960 - Synthetic construct Homo sapiens clone ccsbBroadEn_11354 PDLIM7 gene, encodes complete protein.
CU688348 - Synthetic construct Homo sapiens gateway clone IMAGE:100022931 5' read PDLIM7 mRNA.
JD186288 - Sequence 167312 from Patent EP1572962.
JD127620 - Sequence 108644 from Patent EP1572962.
JD187408 - Sequence 168432 from Patent EP1572962.
JD391588 - Sequence 372612 from Patent EP1572962.
JD478880 - Sequence 459904 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: BC067806, NM_213636
UCSC ID: uc003mhe.1
RefSeq Accession: NM_213636

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: yes RNA accession: BC067806.1
exon count: 13CDS single in 3' UTR: no RNA size: 1919
ORF size: 0CDS single in intron: no Alignment % ID: 99.79
txCdsPredict score: 833.00frame shift in genome: no % Coverage: 99.22
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.