Human Gene KIF13A (uc003nch.4) Description and Page Index
  Description: Homo sapiens kinesin family member 13A (KIF13A), transcript variant 2, mRNA.
RefSeq Summary (NM_001105566): This gene encodes a member of the kinesin family of microtubule-based motor proteins that function in the positioning of endosomes. This family member can direct mannose-6-phosphate receptor-containing vesicles from the trans-Golgi network to the plasma membrane, and it is necessary for the steady-state distribution of late endosomes/lysosomes. It is also required for the translocation of FYVE-CENT and TTC19 from the centrosome to the midbody during cytokinesis, and it plays a role in melanosome maturation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011].
Transcript (Including UTRs)
   Position: hg19 chr6:17,763,924-17,987,854 Size: 223,931 Total Exon Count: 38 Strand: -
Coding Region
   Position: hg19 chr6:17,764,341-17,987,694 Size: 223,354 Coding Exon Count: 38 

Page IndexSequence and LinksGenetic AssociationsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:17,763,924-17,987,854)mRNA (may differ from genome)Protein (1770 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMGIOMIM
PubMedReactomeStanford SOURCETreefamUniProtKBWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): KIF13A
CDC HuGE Published Literature: KIF13A
Positive Disease Associations: height , Prostatic Neoplasms
Related Studies:
  1. height
    Gudbjartsson ,et al. 2008, Many sequence variants affecting diversity of adult human height, Nature genetics 2008 40- 5 : 609-15. [PubMed 18391951]
  2. Prostatic Neoplasms
    Sha Tao et al. Carcinogenesis 2012, A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants., Carcinogenesis. [PubMed 22219177]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.49 RPKM in Artery - Coronary
Total median expression: 340.09 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -101.60160-0.635 Picture PostScript Text
3' UTR -98.70417-0.237 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00225 - Kinesin motor domain
PF00498 - FHA domain
PF12423 - Kinesin protein 1B
PF12473 - Kinesin protein
PF16183 - Kinesin-associated
PF16796 - Microtubule binding

SCOP Domains:
49879 - SMAD/FHA domain
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q9H1H9-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  LP896415 - Sequence 1279 from Patent EP3253886.
AJ291579 - Homo sapiens mRNA for KINESIN-13A2 (KIN13A gene).
AJ291578 - Homo sapiens mRNA for KINESIN-13A1 (KIN13A gene).
AY014403 - Homo sapiens kinesin-like protein RBKIN1 (RBKIN) mRNA, complete cds, alternatively spliced.
AY014404 - Homo sapiens kinesin-like protein RBKIN2 (RBKIN) mRNA, complete cds, alternatively spliced.
BC127115 - Homo sapiens kinesin family member 13A, mRNA (cDNA clone MGC:150707 IMAGE:40125246), complete cds.
BC127116 - Homo sapiens kinesin family member 13A, mRNA (cDNA clone MGC:150708 IMAGE:40125251), complete cds.
BC001730 - Homo sapiens cDNA clone IMAGE:3353875, containing frame-shift errors.
BC023613 - Homo sapiens cDNA clone IMAGE:4646849, containing frame-shift errors.
BC062673 - Homo sapiens kinesin family member 13A, mRNA (cDNA clone IMAGE:6654466), with apparent retained intron.
AK130742 - Homo sapiens cDNA FLJ27232 fis, clone SYN06360.
JD204951 - Sequence 185975 from Patent EP1572962.
JD486786 - Sequence 467810 from Patent EP1572962.
JD404219 - Sequence 385243 from Patent EP1572962.
AK025303 - Homo sapiens cDNA: FLJ21650 fis, clone COL08516.
AK225214 - Homo sapiens mRNA for kinesin family member 13A variant, clone: COL08516.
JD336425 - Sequence 317449 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9H1H9 (Reactome details) participates in the following event(s):

R-HSA-390470 Association of CCT/TriC with other substrates during biosynthesis (unknown chaperone)
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-390466 Chaperonin-mediated protein folding
R-HSA-391251 Protein folding
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001105566, NP_001099036, Q9H1H9-2, RBKIN
UCSC ID: uc003nch.4
RefSeq Accession: NM_001105566
Protein: Q9H1H9-2, splice isoform of Q9H1H9 CCDS: CCDS47381.1, CCDS54967.1, CCDS54968.1, CCDS47380.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001105566.2
exon count: 38CDS single in 3' UTR: no RNA size: 5900
ORF size: 5313CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 10724.00frame shift in genome: no % Coverage: 99.83
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 462# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.