Human Gene PRR3 (uc003nqi.2) Description and Page Index
  Description: Homo sapiens proline rich 3 (PRR3), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr6:30,524,486-30,532,473 Size: 7,988 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr6:30,525,122-30,530,272 Size: 5,151 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:30,524,486-30,532,473)mRNA (may differ from genome)Protein (188 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkHGNCHPRDLynxMGIneXtProt
PubMedStanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: PRR3_HUMAN
DESCRIPTION: RecName: Full=Proline-rich protein 3; AltName: Full=MHC class I region proline-rich protein CAT56;
SIMILARITY: Contains 1 C3H1-type zinc finger.
SEQUENCE CAUTION: Sequence=AAB40147.1; Type=Erroneous initiation;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): PRR3
CDC HuGE Published Literature: PRR3

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.04 RPKM in Ovary
Total median expression: 408.27 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -253.40636-0.398 Picture PostScript Text
3' UTR -708.792201-0.322 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000571 - Znf_CCCH

Pfam Domains:
PF00642 - Zinc finger C-x8-C-x5-C-x3-H type (and similar)
PF14608 - RNA-binding, Nab2-type zinc finger

ModBase Predicted Comparative 3D Structure on P79522
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding


-  Descriptions from all associated GenBank mRNAs
  LF210814 - JP 2014500723-A/18317: Polycomb-Associated Non-Coding RNAs.
U63336 - Human MHC Class I region proline rich protein mRNA, complete cds.
AK316586 - Homo sapiens cDNA, FLJ95224, Homo sapiens proline rich 3 (PRR3), mRNA.
AK298621 - Homo sapiens cDNA FLJ60784 complete cds, highly similar to Proline-rich protein 3.
JD196076 - Sequence 177100 from Patent EP1572962.
JD316182 - Sequence 297206 from Patent EP1572962.
BC126455 - Homo sapiens proline rich 3, mRNA (cDNA clone MGC:161733 IMAGE:8992171), complete cds.
BC126457 - Homo sapiens proline rich 3, mRNA (cDNA clone MGC:161735 IMAGE:8992173), complete cds.
AK074531 - Homo sapiens cDNA FLJ90050 fis, clone HEMBA1002524, highly similar to Proline-rich protein 3.
HQ258105 - Synthetic construct Homo sapiens clone IMAGE:100072414 Unknown protein gene, encodes complete protein.
HQ258598 - Synthetic construct Homo sapiens clone IMAGE:100073140 Unknown protein gene, encodes complete protein.
KJ899647 - Synthetic construct Homo sapiens clone ccsbBroadEn_09041 PRR3 gene, encodes complete protein.
KJ899648 - Synthetic construct Homo sapiens clone ccsbBroadEn_09042 PRR3 gene, encodes complete protein.
LF341353 - JP 2014500723-A/148856: Polycomb-Associated Non-Coding RNAs.
DQ596624 - Homo sapiens piRNA piR-34690, complete sequence.
AK131382 - Homo sapiens cDNA FLJ16455 fis, clone BRAWH3007441.
JD313856 - Sequence 294880 from Patent EP1572962.
JD322040 - Sequence 303064 from Patent EP1572962.
JD164458 - Sequence 145482 from Patent EP1572962.
LF341348 - JP 2014500723-A/148851: Polycomb-Associated Non-Coding RNAs.
JD318959 - Sequence 299983 from Patent EP1572962.
JD083858 - Sequence 64882 from Patent EP1572962.
JD276968 - Sequence 257992 from Patent EP1572962.
JD167465 - Sequence 148489 from Patent EP1572962.
JD563895 - Sequence 544919 from Patent EP1572962.
JD363591 - Sequence 344615 from Patent EP1572962.
JD295801 - Sequence 276825 from Patent EP1572962.
JD546718 - Sequence 527742 from Patent EP1572962.
JD219417 - Sequence 200441 from Patent EP1572962.
JD512134 - Sequence 493158 from Patent EP1572962.
JD520882 - Sequence 501906 from Patent EP1572962.
JD044844 - Sequence 25868 from Patent EP1572962.
JD315378 - Sequence 296402 from Patent EP1572962.
JD091573 - Sequence 72597 from Patent EP1572962.
JD553539 - Sequence 534563 from Patent EP1572962.
JD087299 - Sequence 68323 from Patent EP1572962.
LF341346 - JP 2014500723-A/148849: Polycomb-Associated Non-Coding RNAs.
JD234899 - Sequence 215923 from Patent EP1572962.
LF341345 - JP 2014500723-A/148848: Polycomb-Associated Non-Coding RNAs.
MA446391 - JP 2018138019-A/18317: Polycomb-Associated Non-Coding RNAs.
MA576930 - JP 2018138019-A/148856: Polycomb-Associated Non-Coding RNAs.
MA576925 - JP 2018138019-A/148851: Polycomb-Associated Non-Coding RNAs.
MA576923 - JP 2018138019-A/148849: Polycomb-Associated Non-Coding RNAs.
MA576922 - JP 2018138019-A/148848: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A1A4H4, CAT56, NM_025263, NP_079539, P79522, PRR3_HUMAN, Q5RJB5, Q5STN6
UCSC ID: uc003nqi.2
RefSeq Accession: NM_025263
Protein: P79522 (aka PRR3_HUMAN)
CCDS: CCDS43440.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_025263.3
exon count: 4CDS single in 3' UTR: no RNA size: 3404
ORF size: 567CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 877.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 7
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.