Human Gene STK19 (uc003nyw.3) Description and Page Index
  Description: Homo sapiens serine/threonine kinase 19 (STK19), transcript variant 1, mRNA.
RefSeq Summary (NM_004197): This gene encodes a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr6:31,939,646-31,949,223 Size: 9,578 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr6:31,939,774-31,948,826 Size: 9,053 Coding Exon Count: 8 

Page IndexSequence and LinksGenetic AssociationsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:31,939,646-31,949,223)mRNA (may differ from genome)Protein (364 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkHGNCLynxMGIOMIMPubMed
Stanford SOURCETreefamUniProtKBWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): STK19
CDC HuGE Published Literature: STK19
Positive Disease Associations: Diabetes Mellitus, Type 1 , Lupus Erythematosus, Systemic , Macular Degeneration
Related Studies:
  1. Diabetes Mellitus, Type 1
    , , . [PubMed 0]
  2. Lupus Erythematosus, Systemic
    , , . [PubMed 0]
  3. Lupus Erythematosus, Systemic
    , , . [PubMed 0]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 58.80 RPKM in Adrenal Gland
Total median expression: 734.45 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -36.80128-0.287 Picture PostScript Text
3' UTR -135.40397-0.341 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF10494 - Serine-threonine protein kinase 19

ModBase Predicted Comparative 3D Structure on P49842-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  AK302111 - Homo sapiens cDNA FLJ54971 complete cds, moderately similar to Serine/threonine-protein kinase 19 (EC 2.7.11.1).
BC110347 - Homo sapiens serine/threonine kinase 19, mRNA (cDNA clone MGC:117388 IMAGE:5165123), complete cds.
AK303438 - Homo sapiens cDNA FLJ61515 complete cds, highly similar to Serine/threonine-protein kinase 19 (EC2.7.11.1).
L26260 - Homo sapiens RP protein (RP) mRNA, complete cds.
BC143833 - Homo sapiens serine/threonine kinase 19, mRNA (cDNA clone MGC:177365 IMAGE:9052348), complete cds.
BC143835 - Homo sapiens cDNA clone IMAGE:9052350.
JD463393 - Sequence 444417 from Patent EP1572962.
JD131248 - Sequence 112272 from Patent EP1572962.
BC121128 - Homo sapiens serine/threonine kinase 19, mRNA (cDNA clone MGC:150441 IMAGE:40120738), complete cds.
BC121129 - Homo sapiens serine/threonine kinase 19, mRNA (cDNA clone MGC:150442 IMAGE:40120740), complete cds.
BC016916 - Homo sapiens cDNA clone IMAGE:4400551, containing frame-shift errors.
JD520289 - Sequence 501313 from Patent EP1572962.
KJ900836 - Synthetic construct Homo sapiens clone ccsbBroadEn_10230 STK19 gene, encodes complete protein.
X77386 - H.sapiens G11 mRNA.
AK307198 - Homo sapiens cDNA, FLJ97146.
DQ596449 - Homo sapiens piRNA piR-34515, complete sequence.
JD052605 - Sequence 33629 from Patent EP1572962.
JD176357 - Sequence 157381 from Patent EP1572962.
JD318452 - Sequence 299476 from Patent EP1572962.
JD045256 - Sequence 26280 from Patent EP1572962.
JD527101 - Sequence 508125 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: G11, NM_004197, NP_004188, P49842-2, RP1
UCSC ID: uc003nyw.3
RefSeq Accession: NM_004197
Protein: P49842-2, splice isoform of P49842 CCDS: CCDS4733.1, CCDS34417.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_004197.1
exon count: 8CDS single in 3' UTR: no RNA size: 1620
ORF size: 1095CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2351.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 10
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 258# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.