Human Gene MYO6 (uc003pig.1) Description and Page Index
Description: Homo sapiens myosin VI (MYO6), mRNA. RefSeq Summary (NM_004999): This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]. Transcript (Including UTRs) Position: hg19 chr6:76,458,909-76,617,425 Size: 158,517 Total Exon Count: 29 Strand: + Coding Region Position: hg19 chr6:76,527,265-76,617,424 Size: 90,160 Coding Exon Count: 28
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00063 - Myosin head (motor domain) PF00612 - IQ calmodulin-binding motif
ModBase Predicted Comparative 3D Structure on Q9UM54-5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.