Human Gene IQCE (uc003sml.1) Description and Page Index
  Description: Homo sapiens IQ motif containing E (IQCE), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr7:2,598,632-2,647,189 Size: 48,558 Total Exon Count: 21 Strand: +
Coding Region
   Position: hg19 chr7:2,598,816-2,647,001 Size: 48,186 Coding Exon Count: 21 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:2,598,632-2,647,189)mRNA (may differ from genome)Protein (702 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
OMIMPubMedReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: IQCE_HUMAN
DESCRIPTION: RecName: Full=IQ domain-containing protein E;
SIMILARITY: Contains 2 IQ domains.
SEQUENCE CAUTION: Sequence=BAA82975.2; Type=Erroneous initiation;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): IQCE
CDC HuGE Published Literature: IQCE

-  MalaCards Disease Associations
  MalaCards Gene Search: IQCE
Diseases sorted by gene-association score: polydactyly, postaxial, type a7* (950)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 18.36 RPKM in Testis
Total median expression: 242.54 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -109.30184-0.594 Picture PostScript Text
3' UTR -60.00188-0.319 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000048 - IQ_motif_EF-hand-BS

Pfam Domains:
PF00612 - IQ calmodulin-binding motif

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q6IPM2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Cellular Component:
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0016020 membrane
GO:0042995 cell projection
GO:0060170 ciliary membrane


-  Descriptions from all associated GenBank mRNAs
  BC071858 - Homo sapiens IQ motif containing E, mRNA (cDNA clone MGC:88524 IMAGE:5478116), complete cds.
AK302053 - Homo sapiens cDNA FLJ53236 complete cds, highly similar to Homo sapiens IQ motif containing E (IQCE), mRNA.
AK309646 - Homo sapiens cDNA, FLJ99687.
BC043150 - Homo sapiens IQ motif containing E, mRNA (cDNA clone MGC:41907 IMAGE:5297871), complete cds.
AK092404 - Homo sapiens cDNA FLJ35085 fis, clone PLACE6005487, highly similar to Homo sapiens IQ motif containing E (IQCE), mRNA.
AX747526 - Sequence 1051 from Patent EP1308459.
BC061518 - Homo sapiens IQ motif containing E, mRNA (cDNA clone IMAGE:6501691), partial cds.
AL136792 - Homo sapiens mRNA; cDNA DKFZp434P1219 (from clone DKFZp434P1219).
AK293372 - Homo sapiens cDNA FLJ53968 complete cds, highly similar to Homo sapiens IQ motif containing E (IQCE), mRNA.
KJ534872 - Homo sapiens clone IQCE_iso-A_fetal-F01 IQ motif containing E isoform A (IQCE) mRNA, partial cds, alternatively spliced.
KJ534873 - Homo sapiens clone IQCE_iso-C_fetal-F13 IQ motif containing E isoform C (IQCE) mRNA, partial cds, alternatively spliced.
KJ535081 - Homo sapiens clone IQCE_iso-B_fetal-F02 IQ motif containing E isoform B (IQCE) mRNA, complete cds, alternatively spliced.
AB028946 - Homo sapiens KIAA1023 mRNA for KIAA1023 protein.
AB587351 - Synthetic construct DNA, clone: pF1KA1023, Homo sapiens IQCE gene for IQ motif containing E, without stop codon, in Flexi system.
AM392871 - Synthetic construct Homo sapiens clone IMAGE:100002399 for hypothetical protein (IQCE gene).
AM393235 - Synthetic construct Homo sapiens clone IMAGE:100002400 for hypothetical protein (IQCE gene).
JD142402 - Sequence 123426 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q6IPM2 (Reactome details) participates in the following event(s):

R-HSA-5633051 EFCAB7:IQCE binds EVC2:EVC
R-HSA-5635838 Activation of SMO
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5358351 Signaling by Hedgehog
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: AX747526, IQCE_HUMAN, KIAA1023, NM_152558, NP_689771, Q4G0P7, Q6IPM2, Q6P7T4, Q9H0H7, Q9UPX7
UCSC ID: uc003sml.1
RefSeq Accession: NM_152558
Protein: Q6IPM2 (aka IQCE_HUMAN)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AX747526.1
exon count: 21CDS single in 3' UTR: no RNA size: 2401
ORF size: 2109CDS single in intron: no Alignment % ID: 99.83
txCdsPredict score: 4196.00frame shift in genome: no % Coverage: 99.96
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 328# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.