Human Gene TYW1 (uc003tvn.4) Description and Page Index
Description: Homo sapiens tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) (TYW1), mRNA. RefSeq Summary (NM_018264): Wybutosine (yW) is a hypermodified guanosine found in phenylalanine tRNA adjacent to the anticodon that stabilizes codon-anticodon interactions in the ribosome. In yeast, the homolog of this gene is essential for the synthesis of wybutosine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]. Transcript (Including UTRs) Position: hg19 chr7:66,461,792-66,704,507 Size: 242,716 Total Exon Count: 16 Strand: + Coding Region Position: hg19 chr7:66,461,966-66,703,516 Size: 241,551 Coding Exon Count: 16
ID:TYW1_HUMAN DESCRIPTION: RecName: Full=tRNA wybutosine-synthesizing protein 1 homolog; AltName: Full=Radical S-adenosyl methionine and flavodoxin domain-containing protein 1; AltName: Full=tRNA-yW-synthesizing protein; FUNCTION: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). COFACTOR: Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity). PATHWAY: tRNA modification; wybutosine-tRNA(Phe) biosynthesis. SIMILARITY: Belongs to the TYW1 family. SIMILARITY: Contains 1 flavodoxin-like domain. SEQUENCE CAUTION: Sequence=AAH15591.1; Type=Frameshift; Positions=663; Sequence=BAB14307.1; Type=Erroneous initiation;
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): TYW1 CDC HuGE Published Literature: TYW1
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 102114 - Radical SAM enzymes 52218 - Flavoproteins
ModBase Predicted Comparative 3D Structure on Q9NV66
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.