Human Gene TACC1 (uc003xmd.1) Description and Page Index
  Description: Homo sapiens transforming, acidic coiled-coil containing protein 1 (TACC1), transcript variant 2, mRNA.
RefSeq Summary (NM_001122824): This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY177411.1, SRR1803616.12304.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END##
Transcript (Including UTRs)
   Position: hg19 chr8:38,614,757-38,688,695 Size: 73,939 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr8:38,614,851-38,688,695 Size: 73,845 Coding Exon Count: 4 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:38,614,757-38,688,695)mRNA (may differ from genome)Protein (133 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsGeneNetworkH-INV
HGNCLynxMGIPubMedStanford SOURCEWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TACC1
CDC HuGE Published Literature: TACC1

-  MalaCards Disease Associations
  MalaCards Gene Search: TACC1
Diseases sorted by gene-association score: gliosarcoma* (202), giant cell glioblastoma* (132), breast cancer (3)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 57.86 RPKM in Esophagus - Muscularis
Total median expression: 1170.95 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -30.4094-0.323 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  BX647696 - Homo sapiens mRNA; cDNA DKFZp686K18126 (from clone DKFZp686K18126).
AY072873 - Homo sapiens transforming, acidic coiled-coil containing protein 1 variant TACC1-B (TACC1) mRNA, partial cds; alternatively spliced.
AY072876 - Homo sapiens transforming, acidic coiled-coil containing protein 1 variant TACC1-E (TACC1) mRNA, partial cds; alternatively spliced.
AK304774 - Homo sapiens cDNA FLJ52058 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 1.
AK295071 - Homo sapiens cDNA FLJ50409 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 1.
AK303596 - Homo sapiens cDNA FLJ52382 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 1.
AK304507 - Homo sapiens cDNA FLJ56209 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 1.
BC041391 - Homo sapiens transforming, acidic coiled-coil containing protein 1, mRNA (cDNA clone MGC:43967 IMAGE:5276767), complete cds.
JF432777 - Synthetic construct Homo sapiens clone IMAGE:100074021 transforming, acidic coiled-coil containing protein 1 (TACC1) gene, encodes complete protein.
KJ901774 - Synthetic construct Homo sapiens clone ccsbBroadEn_11168 TACC1 gene, encodes complete protein.
AY072874 - Homo sapiens transforming, acidic coiled-coil containing protein 1 variant TACC1-C (TACC1) mRNA, partial cds; alternatively spliced.
AY072875 - Homo sapiens transforming, acidic coiled-coil containing protein 1 variant TACC1-D (TACC1) mRNA, partial cds; alternatively spliced.
AK308849 - Homo sapiens cDNA, FLJ98890.
AK314620 - Homo sapiens cDNA, FLJ95461, highly similar to Homo sapiens transforming, acidic coiled-coil containing protein 1 (TACC1), mRNA.
AF049910 - Homo sapiens TACC1 (TACC1) mRNA, complete cds.
AY177411 - Homo sapiens transforming acidic coiled-coil containing protein 1 short isoform (TACC1) mRNA, complete cds.
AB463317 - Synthetic construct DNA, clone: pF1KB9572, Homo sapiens TACC1 gene for transforming, acidic coiled-coil containing protein 1, without stop codon, in Flexi system.
AK294931 - Homo sapiens cDNA FLJ50512 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 1.
AK295841 - Homo sapiens cDNA FLJ50411 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 1.
AB029026 - Homo sapiens mRNA for KIAA1103 protein, partial cds.
AK304725 - Homo sapiens cDNA FLJ52297 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 1.
AY039239 - Homo sapiens gastric cancer antigen Ga55 (TACC1) mRNA, partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: AY072874
UCSC ID: uc003xmd.1
RefSeq Accession: NM_001122824

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AY072874.1
exon count: 4CDS single in 3' UTR: no RNA size: 493
ORF size: 399CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 870.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.