Human Gene NEK6 (uc004bof.3) Description and Page Index
  Description: Homo sapiens NIMA-related kinase 6 (NEK6), transcript variant 3, mRNA.
RefSeq Summary (NM_001166167): The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
Transcript (Including UTRs)
   Position: hg19 chr9:127,019,885-127,114,719 Size: 94,835 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr9:127,019,976-127,113,226 Size: 93,251 Coding Exon Count: 10 

Page IndexSequence and LinksGenetic AssociationsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:127,019,885-127,114,719)mRNA (may differ from genome)Protein (331 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsH-INV
HGNCLynxMGIOMIMPubMedReactome
Stanford SOURCEUniProtKBWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): NEK6
CDC HuGE Published Literature: NEK6
Positive Disease Associations: Body Height , Cognitive performance
Related Studies:
  1. Body Height
    , , . [PubMed 0]
  2. Body Height
    , , . [PubMed 0]
  3. Body Height
    , , . [PubMed 0]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D001564 Benzo(a)pyrene
  • C006253 pirinixic acid
  • C016403 2,4-dinitrotoluene
  • C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
  • D015073 2-Acetylaminofluorene
  • C035207 4-amino-2,6-dinitrotoluene
  • C027576 4-hydroxy-2-nonenal
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
  • D015124 8-Bromo Cyclic Adenosine Monophosphate
  • D000082 Acetaminophen
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 62.25 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 376.43 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -27.6091-0.303 Picture PostScript Text
3' UTR -485.251493-0.325 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine kinase

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on Q9HC98-3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  BC000101 - Homo sapiens NIMA (never in mitosis gene a)-related kinase 6, mRNA (cDNA clone MGC:1205 IMAGE:3507262), complete cds.
BC004174 - Homo sapiens NIMA (never in mitosis gene a)-related kinase 6, mRNA (cDNA clone MGC:2768 IMAGE:2958695), complete cds.
BC004209 - Homo sapiens NIMA (never in mitosis gene a)-related kinase 6, mRNA (cDNA clone MGC:4434 IMAGE:2958695), complete cds.
BC012761 - Homo sapiens NIMA (never in mitosis gene a)-related kinase 6, mRNA (cDNA clone MGC:16199 IMAGE:3640103), complete cds.
AB026289 - Homo sapiens mRNA for protein kinase SID6-1512, complete cds.
AF087909 - Homo sapiens NIMA-related kinase 6 (NEK6) mRNA, complete cds.
AK313071 - Homo sapiens cDNA, FLJ93552, Homo sapiens NIMA (never in mitosis gene a)-related kinase 6 (NEK6), mRNA.
AK294614 - Homo sapiens cDNA FLJ55200 complete cds, highly similar to Serine/threonine-protein kinase Nek6 (EC 2.7.11.1).
AB384987 - Synthetic construct DNA, clone: pF1KB4782, Homo sapiens NEK6 gene for serine/threonine-protein kinase Nek6, complete cds, without stop codon, in Flexi system.
JD392026 - Sequence 373050 from Patent EP1572962.
CU674034 - Synthetic construct Homo sapiens gateway clone IMAGE:100018847 5' read NEK6 mRNA.
KJ898286 - Synthetic construct Homo sapiens clone ccsbBroadEn_07680 NEK6 gene, encodes complete protein.
KJ905404 - Synthetic construct Homo sapiens clone ccsbBroadEn_14978 NEK6 gene, encodes complete protein.
CR457091 - Homo sapiens full open reading frame cDNA clone RZPDo834E1011D for gene NEK6, NIMA (never in mitosis gene a)-related kinase 6; complete cds, incl. stopcodon.
CR542222 - Homo sapiens full open reading frame cDNA clone RZPDo834C0925D for gene NEK6, NIMA (never in mitosis gene a)-related kinase 6; complete cds, without stopcodon.
JD360907 - Sequence 341931 from Patent EP1572962.
JD344568 - Sequence 325592 from Patent EP1572962.
JD332912 - Sequence 313936 from Patent EP1572962.
JD449507 - Sequence 430531 from Patent EP1572962.
JD354646 - Sequence 335670 from Patent EP1572962.
JD421769 - Sequence 402793 from Patent EP1572962.
JD538538 - Sequence 519562 from Patent EP1572962.
JD175076 - Sequence 156100 from Patent EP1572962.
JD268605 - Sequence 249629 from Patent EP1572962.
JD232238 - Sequence 213262 from Patent EP1572962.
JD088111 - Sequence 69135 from Patent EP1572962.
JD442306 - Sequence 423330 from Patent EP1572962.
JD159125 - Sequence 140149 from Patent EP1572962.
JD074327 - Sequence 55351 from Patent EP1572962.
JD454734 - Sequence 435758 from Patent EP1572962.
JD214525 - Sequence 195549 from Patent EP1572962.
JD372999 - Sequence 354023 from Patent EP1572962.
JD205607 - Sequence 186631 from Patent EP1572962.
JD334829 - Sequence 315853 from Patent EP1572962.
AJ420460 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1636598.
JD251640 - Sequence 232664 from Patent EP1572962.
JD049234 - Sequence 30258 from Patent EP1572962.
JD561959 - Sequence 542983 from Patent EP1572962.
JD492302 - Sequence 473326 from Patent EP1572962.
JD064865 - Sequence 45889 from Patent EP1572962.
JD268310 - Sequence 249334 from Patent EP1572962.
JD254560 - Sequence 235584 from Patent EP1572962.
JD193788 - Sequence 174812 from Patent EP1572962.
JD319902 - Sequence 300926 from Patent EP1572962.
JD365491 - Sequence 346515 from Patent EP1572962.
JD425171 - Sequence 406195 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9HC98 (Reactome details) participates in the following event(s):

R-HSA-2980720 NEK9 binds NEK6/NEK7 in the cytosol
R-HSA-2984258 NEK9 phosphorylates NEK6/NEK7
R-HSA-2990880 NEK6/NEK7 phosphorylates NUP98
R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7
R-HSA-2980766 Nuclear Envelope Breakdown
R-HSA-68875 Mitotic Prophase
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-68886 M Phase
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-1640170 Cell Cycle

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001166167, NP_001159639, Q9HC98-3
UCSC ID: uc004bof.3
RefSeq Accession: NM_001166167
Protein: Q9HC98-3, splice isoform of Q9HC98 CCDS: CCDS55339.1, CCDS55338.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001166167.1
exon count: 10CDS single in 3' UTR: no RNA size: 2592
ORF size: 996CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1711.00frame shift in genome: no % Coverage: 99.54
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.