Human Gene FAM102A (uc004bsw.1) Description and Page Index
  Description: Homo sapiens family with sequence similarity 102, member A (FAM102A), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr9:130,702,861-130,712,993 Size: 10,133 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr9:130,705,471-130,710,681 Size: 5,211 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr9:130,702,861-130,712,993)mRNA (may differ from genome)Protein (242 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
PubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Protein FAM102A; AltName: Full=Early estrogen-induced gene 1 protein;
FUNCTION: May play a role in estrogen action.
INDUCTION: By 17-beta-estradiol but also by a group of natural and synthetic estrogens as well as by estrogenic environmental compounds. Repressed by the antiestrogen 4-hydroxy-tamoxifen.
SIMILARITY: Belongs to the FAM102 family.
SEQUENCE CAUTION: Sequence=CAI12618.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 47.99 RPKM in Small Intestine - Terminal Ileum
Total median expression: 1232.76 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -108.62304-0.357 Picture PostScript Text
3' UTR -1082.622610-0.415 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019448 - NT-C2

ModBase Predicted Comparative 3D Structure on Q5T9C2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

-  Descriptions from all associated GenBank mRNAs
  LP896559 - Sequence 1423 from Patent EP3253886.
AL049365 - Homo sapiens mRNA; cDNA DKFZp586A0618 (from clone DKFZp586A0618).
AK074108 - Homo sapiens mRNA for FLJ00179 protein.
BC047949 - Homo sapiens family with sequence similarity 102, member A, mRNA (cDNA clone IMAGE:5763298).
AK058004 - Homo sapiens cDNA FLJ25275 fis, clone STM06043.
BC142952 - Homo sapiens cDNA clone IMAGE:8860338.
BC137087 - Homo sapiens family with sequence similarity 102, member A, mRNA (cDNA clone MGC:168707 IMAGE:9021084), complete cds.
BC137088 - Homo sapiens family with sequence similarity 102, member A, mRNA (cDNA clone MGC:168708 IMAGE:9021085), complete cds.
KJ900721 - Synthetic construct Homo sapiens clone ccsbBroadEn_10115 FAM102A gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: A2A329, C9orf132, EEIG1, F102A_HUMAN, NM_203305, NP_976050, Q5T9C2, Q8TEL4
UCSC ID: uc004bsw.1
RefSeq Accession: NM_203305
Protein: Q5T9C2 (aka F102A_HUMAN)
CCDS: CCDS6888.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_203305.2
exon count: 8CDS single in 3' UTR: no RNA size: 3643
ORF size: 729CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1440.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 175# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.