Human Gene HDAC6 (uc004dks.1) Description and Page Index
Description: Homo sapiens histone deacetylase 6 (HDAC6), mRNA. RefSeq Summary (NM_006044): Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.144770.1, SRR1660803.117327.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000334136.11/ ENSP00000334061.5 RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chrX:48,660,487-48,683,380 Size: 22,894 Total Exon Count: 29 Strand: + Coding Region Position: hg19 chrX:48,661,100-48,683,022 Size: 21,923 Coding Exon Count: 28
ID:HDAC6_HUMAN DESCRIPTION: RecName: Full=Histone deacetylase 6; Short=HD6; EC=18.104.22.168; FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. FUNCTION: In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy. CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone. COFACTOR: Binds 3 zinc ions per subunit. SUBUNIT: Interacts with CBFA2T3, HDAC11 and SIRT2. Interacts with F-actin. Interacts with BBIP10. Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions. Interacts with CYLD. Interacts with ZMYND15 (By similarity). Interacts with DDIT3/CHOP. INTERACTION: Q9HCU9:BRMS1; NbExp=2; IntAct=EBI-301697, EBI-714781; Q62623:Cdc20 (xeno); NbExp=2; IntAct=EBI-301697, EBI-2256532; P00533:EGFR; NbExp=8; IntAct=EBI-301697, EBI-297353; P03409:tax (xeno); NbExp=4; IntAct=EBI-301697, EBI-5236464; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=It is mainly cytoplasmic, where it is associated with microtubules. PTM: Phosphorylated by AURKA. PTM: Ubiquitinated. Its polyubiquitination however does not lead to its degradation. PTM: Sumoylated in vitro. SIMILARITY: Belongs to the histone deacetylase family. HD type 2 subfamily. SIMILARITY: Contains 1 UBP-type zinc finger. SEQUENCE CAUTION: Sequence=BAA74924.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): HDAC6 CDC HuGE Published Literature: HDAC6
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UBN7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000209 protein polyubiquitination GO:0006325 chromatin organization GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006476 protein deacetylation GO:0006511 ubiquitin-dependent protein catabolic process GO:0006515 misfolded or incompletely synthesized protein catabolic process GO:0006886 intracellular protein transport GO:0006914 autophagy GO:0007026 negative regulation of microtubule depolymerization GO:0009636 response to toxic substance GO:0009967 positive regulation of signal transduction GO:0010033 response to organic substance GO:0010469 regulation of receptor activity GO:0010506 regulation of autophagy GO:0010634 positive regulation of epithelial cell migration GO:0010727 negative regulation of hydrogen peroxide metabolic process GO:0010870 positive regulation of receptor biosynthetic process GO:0016241 regulation of macroautophagy GO:0016575 histone deacetylation GO:0031647 regulation of protein stability GO:0032418 lysosome localization GO:0032461 positive regulation of protein oligomerization GO:0032984 macromolecular complex disassembly GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0034983 peptidyl-lysine deacetylation GO:0035967 cellular response to topologically incorrect protein GO:0040029 regulation of gene expression, epigenetic GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043242 negative regulation of protein complex disassembly GO:0045598 regulation of fat cell differentiation GO:0045861 negative regulation of proteolysis GO:0045892 negative regulation of transcription, DNA-templated GO:0048668 collateral sprouting GO:0051354 negative regulation of oxidoreductase activity GO:0051646 mitochondrion localization GO:0051788 response to misfolded protein GO:0060271 cilium assembly GO:0060632 regulation of microtubule-based movement GO:0060765 regulation of androgen receptor signaling pathway GO:0060997 dendritic spine morphogenesis GO:0061734 parkin-mediated mitophagy in response to mitochondrial depolarization GO:0070201 regulation of establishment of protein localization GO:0070301 cellular response to hydrogen peroxide GO:0070842 aggresome assembly GO:0070845 polyubiquitinated misfolded protein transport GO:0070846 Hsp90 deacetylation GO:0070848 response to growth factor GO:0070932 histone H3 deacetylation GO:0071218 cellular response to misfolded protein GO:0090035 positive regulation of chaperone-mediated protein complex assembly GO:0090042 tubulin deacetylation GO:0098779 mitophagy in response to mitochondrial depolarization GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death GO:1903146 regulation of mitophagy