Human Gene SLC35E2B (uc009vkn.2) Description and Page Index
  Description: Homo sapiens solute carrier family 35, member E2B (SLC35E2B), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:1,601,877-1,624,243 Size: 22,367 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr1:1,602,944-1,608,138 Size: 5,195 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:1,601,877-1,624,243)mRNA (may differ from genome)Protein (236 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsH-INVHGNC
LynxMGIneXtProtPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Solute carrier family 35 member E2B;
FUNCTION: Putative transporter (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the TPT transporter family. SLC35E subfamily.
SEQUENCE CAUTION: Sequence=BAA32292.3; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 23.88 RPKM in Pituitary
Total median expression: 583.93 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -275.01503-0.547 Picture PostScript Text
3' UTR -422.141067-0.396 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000620 - DMT
IPR004853 - DUF250

Pfam Domains:
PF03151 - Triose-phosphate Transporter family

ModBase Predicted Comparative 3D Structure on P0CK96
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  BC062371 - Homo sapiens solute carrier family 35, member E2, mRNA (cDNA clone IMAGE:3845538), partial cds.
CR936618 - Homo sapiens mRNA; cDNA DKFZp686M0869 (from clone DKFZp686M0869).
AB007916 - Homo sapiens KIAA0447 mRNA for KIAA0447 protein.
BC110653 - Homo sapiens similar to solute carrier family 35, member E2, mRNA (cDNA clone MGC:117254 IMAGE:4392812), complete cds.
AK125619 - Homo sapiens cDNA FLJ43631 fis, clone SPLEN2031547.
KJ900803 - Synthetic construct Homo sapiens clone ccsbBroadEn_10197 SLC35E2B gene, encodes complete protein.
AB384481 - Synthetic construct DNA, clone: pF1KA0447, Homo sapiens KIAA0447 gene for KIAA0447 protein, complete cds, without stop codon, in Flexi system.
AK307886 - Homo sapiens cDNA, FLJ97834.
BC092507 - Homo sapiens similar to solute carrier family 35, member E2, mRNA (cDNA clone IMAGE:4374954), with apparent retained intron.
JD039920 - Sequence 20944 from Patent EP1572962.
JD517682 - Sequence 498706 from Patent EP1572962.
JD332085 - Sequence 313109 from Patent EP1572962.
JD517681 - Sequence 498705 from Patent EP1572962.
JD366503 - Sequence 347527 from Patent EP1572962.
JD366504 - Sequence 347528 from Patent EP1572962.
JD366505 - Sequence 347529 from Patent EP1572962.
JD366506 - Sequence 347530 from Patent EP1572962.
JD383022 - Sequence 364046 from Patent EP1572962.
JD090174 - Sequence 71198 from Patent EP1572962.
JD498046 - Sequence 479070 from Patent EP1572962.
JD409551 - Sequence 390575 from Patent EP1572962.
JD058021 - Sequence 39045 from Patent EP1572962.
JD100866 - Sequence 81890 from Patent EP1572962.
JD247163 - Sequence 228187 from Patent EP1572962.
JD487040 - Sequence 468064 from Patent EP1572962.
JD210166 - Sequence 191190 from Patent EP1572962.
JD400167 - Sequence 381191 from Patent EP1572962.
JD565129 - Sequence 546153 from Patent EP1572962.
JD404100 - Sequence 385124 from Patent EP1572962.
JD178248 - Sequence 159272 from Patent EP1572962.
JD253454 - Sequence 234478 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KWR0, BC092507, KIAA0447, NM_001199787, NP_001186716, O75035, P0CK96, Q2TAY8, Q569F8, Q5CZA4, Q9Y3J8, S352B_HUMAN
UCSC ID: uc009vkn.2
RefSeq Accession: NM_001199787
Protein: P0CK96 (aka S352B_HUMAN)

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: BC092507.1
exon count: 5CDS single in 3' UTR: no RNA size: 2199
ORF size: 711CDS single in intron: no Alignment % ID: 99.82
txCdsPredict score: 1335.00frame shift in genome: no % Coverage: 99.32
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 1071# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.