Human Gene CELA3B (uc009vqf.3) Description and Page Index
  Description: Homo sapiens chymotrypsin-like elastase family, member 3B (CELA3B), mRNA.
RefSeq Summary (NM_007352): Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq, May 2009]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M18692.1, DRR138519.19030.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000337107.11/ ENSP00000338369.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr1:22,303,418-22,333,141 Size: 29,724 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr1:22,303,536-22,332,293 Size: 28,758 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:22,303,418-22,333,141)mRNA (may differ from genome)Protein (120 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsGeneNetworkH-INV
HGNCLynxMGIPubMedStanford SOURCETreefam
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: B1AQ52_HUMAN
DESCRIPTION: SubName: Full=Chymotrypsin-like elastase family member 3A; SubName: Full=Elastase 3A, pancreatic;
SIMILARITY: Belongs to the peptidase S1 family.

-  MalaCards Disease Associations
  MalaCards Gene Search: CELA3B
Diseases sorted by gene-association score: actinobacillosis (3), pleuropneumonia (2), pancreas disease (2), retinitis pigmentosa 19 (2), holoprosencephaly 1 (1), pancreatic steatorrhea (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 24050.20 RPKM in Pancreas
Total median expression: 24098.83 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -26.20118-0.222 Picture PostScript Text
3' UTR -328.83848-0.388 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009003 - Pept_cys/ser_Trypsin-like
IPR018114 - Peptidase_S1/S6_AS
IPR001254 - Peptidase_S1_S6

Pfam Domains:
PF00089 - Trypsin

SCOP Domains:
50494 - Trypsin-like serine proteases

ModBase Predicted Comparative 3D Structure on B1AQ52
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004252 serine-type endopeptidase activity

Biological Process:
GO:0006508 proteolysis


-  Descriptions from all associated GenBank mRNAs
  BC005216 - Homo sapiens elastase 3B, pancreatic, mRNA (cDNA clone MGC:12233 IMAGE:3949903), complete cds.
AK308518 - Homo sapiens cDNA, FLJ98559.
AK092382 - Homo sapiens cDNA FLJ35063 fis, clone PANCR1000086, highly similar to ELASTASE IIIB PRECURSOR (EC 3.4.21.70).
AX747509 - Sequence 1034 from Patent EP1308459.
M18692 - Human elastase III B mRNA, complete cds, clone pCL1E3.
E01257 - cDNA encoding human pancreatic elastase 3B.
AK315798 - Homo sapiens cDNA, FLJ96919, highly similar to Homo sapiens elastase 3B, pancreatic (ELA3B), mRNA.
AK308510 - Homo sapiens cDNA, FLJ98551.
KJ898492 - Synthetic construct Homo sapiens clone ccsbBroadEn_07886 CELA3B gene, encodes complete protein.
M16630 - Human protease E mRNA, 3' end.
D00306 - Homo sapiens mRNA for pancreatic protease E precursor, complete cds.
BC015103 - Homo sapiens elastase 3A, pancreatic, mRNA (cDNA clone MGC:22851 IMAGE:3950076), complete cds.
BC005918 - Homo sapiens elastase 3A, pancreatic, mRNA (cDNA clone MGC:14514 IMAGE:4295129), complete cds.
BC007028 - Homo sapiens elastase 3A, pancreatic, mRNA (cDNA clone MGC:12383 IMAGE:3950453), complete cds.
AK308514 - Homo sapiens cDNA, FLJ98555.
BC008383 - Homo sapiens elastase 3A, pancreatic, mRNA (cDNA clone MGC:12505 IMAGE:3949901), complete cds.
AK225620 - Homo sapiens mRNA for elastase 3A, pancreatic preproprotein variant, clone: PNC07621.
CU678941 - Synthetic construct Homo sapiens gateway clone IMAGE:100016938 5' read ELA3A mRNA.
KJ898164 - Synthetic construct Homo sapiens clone ccsbBroadEn_07558 CELA3A gene, encodes complete protein.
DQ896490 - Synthetic construct Homo sapiens clone IMAGE:100010950; FLH194807.01L; RZPDo839F0470D elastase 3A, pancreatic (ELA3A) gene, encodes complete protein.
KJ906025 - Synthetic construct Homo sapiens clone ccsbBroadEn_15695 CELA3A gene, encodes complete protein.
CU675183 - Synthetic construct Homo sapiens gateway clone IMAGE:100023343 5' read ELA3A mRNA.
KJ898165 - Synthetic construct Homo sapiens clone ccsbBroadEn_07559 CELA3A gene, encodes complete protein.
DQ893182 - Synthetic construct clone IMAGE:100005812; FLH194811.01X; RZPDo839F0480D elastase 3A, pancreatic (ELA3A) gene, encodes complete protein.
E00833 - DNA sequence of human elastase I.
E01101 - DNA sequence of human pancreas elastase IIIA.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_pepiPathway - Proepithelin Conversion to Epithelin and Wound Repair Control

-  Other Names for This Gene
  Alternate Gene Symbols: AK308518, B1AQ52, B1AQ52_HUMAN, CELA3A, ELA3A, RP11-26H16.2-002
UCSC ID: uc009vqf.3
RefSeq Accession: NM_007352
Protein: B1AQ52

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK308518.1
exon count: 4CDS single in 3' UTR: no RNA size: 1151
ORF size: 363CDS single in intron: no Alignment % ID: 99.83
txCdsPredict score: 924.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 852# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.