Human Gene GADD45A (uc009wbc.2) Description and Page Index
  Description: Homo sapiens growth arrest and DNA-damage-inducible, alpha (GADD45A), transcript variant 3, mRNA.
RefSeq Summary (NM_001199742): This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010].
Transcript (Including UTRs)
   Position: hg19 chr1:68,150,860-68,154,021 Size: 3,162 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr1:68,151,178-68,153,380 Size: 2,203 Coding Exon Count: 3 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:68,150,860-68,154,021)mRNA (may differ from genome)Protein (60 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsH-INV
HGNCLynxMGIOMIMPubMedStanford SOURCE
TreefamUniProtKBWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): GADD45A
CDC HuGE Published Literature: GADD45A

-  MalaCards Disease Associations
  MalaCards Gene Search: GADD45A
Diseases sorted by gene-association score: small intestine neuroendocrine neoplasm (11), ataxia-telangiectasia (5), prostate disease (4), pancreatic cancer (3), lung cancer (3), breast cancer (2), colorectal cancer (2), esophageal cancer (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 97.75 RPKM in Artery - Aorta
Total median expression: 1161.13 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -161.50318-0.508 Picture PostScript Text
3' UTR -135.40641-0.211 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024824 - GADD45

ModBase Predicted Comparative 3D Structure on A5JUZ3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0006950 response to stress
GO:0051726 regulation of cell cycle

Cellular Component:
GO:0005634 nucleus
GO:0016607 nuclear speck


-  Descriptions from all associated GenBank mRNAs
  AK314991 - Homo sapiens cDNA, FLJ95917, Homo sapiens growth arrest and DNA-damage-inducible, alpha(GADD45A), mRNA.
M60974 - Human growth arrest and DNA-damage-inducible protein (gadd45) mRNA, complete cds.
JD454126 - Sequence 435150 from Patent EP1572962.
DQ008445 - Homo sapiens growth arrest and DNA-damage-inducible 45 alpha (GADD45A) mRNA, complete cds, alternatively spliced.
EF581092 - Homo sapiens growth arrest and DNA-damage-inducible 45 alpha (GADD45A) mRNA, complete cds, alternatively spliced.
EF614238 - Homo sapiens growth arrest and DNA-damage-inducible 45 alpha (GADD45A) mRNA, complete sequence, alternatively spliced.
BC011757 - Homo sapiens growth arrest and DNA-damage-inducible, alpha, mRNA (cDNA clone MGC:19584 IMAGE:3530326), complete cds.
JD205009 - Sequence 186033 from Patent EP1572962.
JD461394 - Sequence 442418 from Patent EP1572962.
JD497057 - Sequence 478081 from Patent EP1572962.
JD139904 - Sequence 120928 from Patent EP1572962.
AB463698 - Synthetic construct DNA, clone: pF1KB8372, Homo sapiens GADD45A gene for growth arrest and DNA-damage-inducible, alpha, without stop codon, in Flexi system.
AM393439 - Synthetic construct Homo sapiens clone IMAGE:100002579 for hypothetical protein (GADD45A gene).
DQ893229 - Synthetic construct clone IMAGE:100005859; FLH195430.01X; RZPDo839C04152D growth arrest and DNA-damage-inducible, alpha (GADD45A) gene, encodes complete protein.
DQ896558 - Synthetic construct Homo sapiens clone IMAGE:100011018; FLH195426.01L; RZPDo839C04151D growth arrest and DNA-damage-inducible, alpha (GADD45A) gene, encodes complete protein.
KJ891036 - Synthetic construct Homo sapiens clone ccsbBroadEn_00430 GADD45A gene, encodes complete protein.
JD025741 - Sequence 6765 from Patent EP1572962.
JD154861 - Sequence 135885 from Patent EP1572962.
JD102309 - Sequence 83333 from Patent EP1572962.
JD449371 - Sequence 430395 from Patent EP1572962.
JD535217 - Sequence 516241 from Patent EP1572962.
JD544765 - Sequence 525789 from Patent EP1572962.
JD350146 - Sequence 331170 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04010 - MAPK signaling pathway
hsa04110 - Cell cycle
hsa04115 - p53 signaling pathway

BioCarta from NCI Cancer Genome Anatomy Project
h_g2Pathway - Cell Cycle: G2/M Checkpoint
h_atmPathway - ATM Signaling Pathway
h_p53Pathway - p53 Signaling Pathway
h_p53hypoxiaPathway - Hypoxia and p53 in the Cardiovascular system

-  Other Names for This Gene
  Alternate Gene Symbols: A5JUZ3, A5JUZ3_HUMAN, NM_001199742, NP_001186671
UCSC ID: uc009wbc.2
RefSeq Accession: NM_001199742
Protein: A5JUZ3

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001199742.1
exon count: 3CDS single in 3' UTR: no RNA size: 1160
ORF size: 183CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 566.00frame shift in genome: no % Coverage: 98.45
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.