Human Gene GADD45A (uc009wbd.2) Description and Page Index
  Description: Homo sapiens growth arrest and DNA-damage-inducible, alpha (GADD45A), transcript variant 3, mRNA.
RefSeq Summary (NM_001199742): This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010].
Transcript (Including UTRs)
   Position: hg19 chr1:68,150,860-68,154,021 Size: 3,162 Total Exon Count: 2 Strand: +

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionOther SpeciesmRNA DescriptionsPathwaysOther NamesModel Information
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:68,150,860-68,154,021)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
PubMedStanford SOURCETreefamWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): GADD45A
CDC HuGE Published Literature: GADD45A

-  MalaCards Disease Associations
  MalaCards Gene Search: GADD45A
Diseases sorted by gene-association score: small intestine neuroendocrine neoplasm (11), ataxia-telangiectasia (5), prostate disease (4), pancreatic cancer (3), lung cancer (3), breast cancer (2), colorectal cancer (2), esophageal cancer (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 97.75 RPKM in Artery - Aorta
Total median expression: 1161.13 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Descriptions from all associated GenBank mRNAs
  AK314991 - Homo sapiens cDNA, FLJ95917, Homo sapiens growth arrest and DNA-damage-inducible, alpha(GADD45A), mRNA.
M60974 - Human growth arrest and DNA-damage-inducible protein (gadd45) mRNA, complete cds.
JD454126 - Sequence 435150 from Patent EP1572962.
DQ008445 - Homo sapiens growth arrest and DNA-damage-inducible 45 alpha (GADD45A) mRNA, complete cds, alternatively spliced.
EF581092 - Homo sapiens growth arrest and DNA-damage-inducible 45 alpha (GADD45A) mRNA, complete cds, alternatively spliced.
EF614238 - Homo sapiens growth arrest and DNA-damage-inducible 45 alpha (GADD45A) mRNA, complete sequence, alternatively spliced.
BC011757 - Homo sapiens growth arrest and DNA-damage-inducible, alpha, mRNA (cDNA clone MGC:19584 IMAGE:3530326), complete cds.
JD205009 - Sequence 186033 from Patent EP1572962.
JD461394 - Sequence 442418 from Patent EP1572962.
JD497057 - Sequence 478081 from Patent EP1572962.
JD139904 - Sequence 120928 from Patent EP1572962.
AB463698 - Synthetic construct DNA, clone: pF1KB8372, Homo sapiens GADD45A gene for growth arrest and DNA-damage-inducible, alpha, without stop codon, in Flexi system.
AM393439 - Synthetic construct Homo sapiens clone IMAGE:100002579 for hypothetical protein (GADD45A gene).
DQ893229 - Synthetic construct clone IMAGE:100005859; FLH195430.01X; RZPDo839C04152D growth arrest and DNA-damage-inducible, alpha (GADD45A) gene, encodes complete protein.
DQ896558 - Synthetic construct Homo sapiens clone IMAGE:100011018; FLH195426.01L; RZPDo839C04151D growth arrest and DNA-damage-inducible, alpha (GADD45A) gene, encodes complete protein.
KJ891036 - Synthetic construct Homo sapiens clone ccsbBroadEn_00430 GADD45A gene, encodes complete protein.
JD154861 - Sequence 135885 from Patent EP1572962.
JD102309 - Sequence 83333 from Patent EP1572962.
JD449371 - Sequence 430395 from Patent EP1572962.
JD535217 - Sequence 516241 from Patent EP1572962.
JD544765 - Sequence 525789 from Patent EP1572962.
JD350146 - Sequence 331170 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04010 - MAPK signaling pathway
hsa04110 - Cell cycle
hsa04115 - p53 signaling pathway

BioCarta from NCI Cancer Genome Anatomy Project
h_g2Pathway - Cell Cycle: G2/M Checkpoint
h_atmPathway - ATM Signaling Pathway
h_p53Pathway - p53 Signaling Pathway
h_p53hypoxiaPathway - Hypoxia and p53 in the Cardiovascular system

-  Other Names for This Gene
  Alternate Gene Symbols: EF614238
UCSC ID: uc009wbd.2
RefSeq Accession: NM_001199742

-  Gene Model Information
category: nearCoding nonsense-mediated-decay: no RNA accession: EF614238.1
exon count: 2CDS single in 3' UTR: no RNA size: 652
ORF size: 0CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 362.00frame shift in genome: no % Coverage: 99.85
has start codon: no stop codon in genome: no # of Alignments: 1
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.