Human Gene RPS6KC1 (uc009xdh.3) Description and Page Index
  Description: Homo sapiens ribosomal protein S6 kinase, 52kDa, polypeptide 1 (RPS6KC1), transcript variant 2, mRNA.
RefSeq Summary (NM_001136138): Sphingosine kinase catalyzes the formation of sphingosine 1 phosphate, a lipid cellular messenger. The protein encoded by this gene can bind to sphingosine kinase and to phosphatidylinositol 3-phosphate, suggesting a role in sphingosine 1 phophate signaling. The encoded protein can also bind to peroxiredoxin-3 and may help transport it to mitochondria. [provided by RefSeq, Mar 2017].
Transcript (Including UTRs)
   Position: hg19 chr1:213,224,588-213,234,869 Size: 10,282 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr1:213,224,747-213,234,867 Size: 10,121 Coding Exon Count: 2 

Page IndexSequence and LinksCTDGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureOther SpeciesmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:213,224,588-213,234,869)mRNA (may differ from genome)Protein (83 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
HGNCLynxMGIPubMedStanford SOURCEWikipedia

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.16 RPKM in Testis
Total median expression: 237.70 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -88.30159-0.555 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Descriptions from all associated GenBank mRNAs
  AK122989 - Homo sapiens cDNA FLJ16747 fis, clone FCBBF3008159, highly similar to Ribosomal protein S6 kinase delta-1 (EC
AK299298 - Homo sapiens cDNA FLJ50840 complete cds, highly similar to Ribosomal protein S6 kinase delta-1 (EC
AF477978 - Homo sapiens RSK-like protein (RPK118) mRNA, complete cds.
AK295053 - Homo sapiens cDNA FLJ61257 complete cds, highly similar to Ribosomal protein S6 kinase delta-1 (EC
AK122921 - Homo sapiens cDNA FLJ16601 fis, clone TESTI4007369, highly similar to Homo sapiens ribosomal protein S6 kinase, 52kDa, polypeptide 1 (RPS6KC1).
BC104769 - Homo sapiens ribosomal protein S6 kinase, 52kDa, polypeptide 1, mRNA (cDNA clone MGC:132429 IMAGE:8143772), complete cds.
BC143449 - Homo sapiens cDNA clone IMAGE:9051957, with apparent retained intron.
BC143473 - Homo sapiens cDNA clone IMAGE:9051981.
BC143474 - Homo sapiens cDNA clone IMAGE:9051982, containing frame-shift errors.
AB070706 - Homo sapiens RPK118 mRNA for RSK-like protein, complete cds.
JD144258 - Sequence 125282 from Patent EP1572962.
JD542135 - Sequence 523159 from Patent EP1572962.
JD211256 - Sequence 192280 from Patent EP1572962.
EF491805 - Homo sapiens clone RPS6KC1 mRNA, partial sequence; alternatively spliced.

-  Other Names for This Gene
  Alternate Gene Symbols: EF491805, uc009xdh.2
UCSC ID: uc009xdh.3
RefSeq Accession: NM_001136138

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: EF491805.1
exon count: 2CDS single in 3' UTR: no RNA size: 120
ORF size: 249CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 626.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.