Human Gene JMJD1C (uc009xpj.2) Description and Page Index
  Description: Homo sapiens jumonji domain containing 1C (JMJD1C), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr10:64,927,120-65,028,982 Size: 101,863 Total Exon Count: 22 Strand: -


Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionOther SpeciesmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:64,927,120-65,028,982)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblExonPrimerGeneNetworkH-INV
HGNCLynxPubMedStanford SOURCE

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): JMJD1C
CDC HuGE Published Literature: JMJD1C
Positive Disease Associations: Alkaline Phosphatase , C-Reactive Protein , Face , mean platelet volume , plasma levels of liver enzymes , Platelet Aggregation , Platelet Count , Triglycerides
Related Studies:
  1. Alkaline Phosphatase
    Xin Yuan et al. American journal of human genetics 2008, Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes., American journal of human genetics. [PubMed 18940312]
  2. Alkaline Phosphatase
    Xin Yuan et al. American journal of human genetics 2008, Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes., American journal of human genetics. [PubMed 18940312]
  3. Alkaline Phosphatase
    John C Chambers et al. Nature genetics 2011, Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma., Nature genetics. [PubMed 22001757]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: JMJD1C
Diseases sorted by gene-association score: central nervous system germinoma* (25), rett syndrome (9), velocardiofacial syndrome* (7), persistent hyperplastic primary vitreous (4), intellectual disability (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D000082 Acetaminophen
  • C023514 2,6-dinitrotoluene
  • C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
  • D016604 Aflatoxin B1
  • D000643 Ammonium Chloride
  • D017638 Asbestos, Crocidolite
  • D019256 Cadmium Chloride
  • D004237 Diuron
  • D005557 Formaldehyde
          more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 21.63 RPKM in Brain - Cerebellum
Total median expression: 364.75 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  EF068222 - Homo sapiens jumonji domain-containing 1 C splice variant (JMJD1C) mRNA, complete cds, alternatively spliced.
BX537954 - Homo sapiens mRNA; cDNA DKFZp686K091 (from clone DKFZp686K091); complete cds.
BC126403 - Homo sapiens cDNA clone IMAGE:8992119, containing frame-shift errors.
BC143722 - Homo sapiens jumonji domain containing 1C, mRNA (cDNA clone MGC:177253 IMAGE:9052236), complete cds.
AK027280 - Homo sapiens cDNA FLJ14374 fis, clone HEMBA1001635.
BC108649 - Homo sapiens jumonji domain containing 1C, mRNA (cDNA clone IMAGE:6069106), with apparent retained intron.
AL831917 - Homo sapiens mRNA; cDNA DKFZp761F0118 (from clone DKFZp761F0118).
BC047331 - Homo sapiens jumonji domain containing 1C, mRNA (cDNA clone IMAGE:4456196), partial cds.
BC065742 - Homo sapiens jumonji domain containing 1C, mRNA (cDNA clone IMAGE:4702370).
BC037981 - Homo sapiens jumonji domain containing 1C, mRNA (cDNA clone IMAGE:5245966), with apparent retained intron.
AK123507 - Homo sapiens cDNA FLJ41513 fis, clone BRTHA2010191.
AB037801 - Homo sapiens mRNA for KIAA1380 protein, partial cds.
JD469834 - Sequence 450858 from Patent EP1572962.
JD229185 - Sequence 210209 from Patent EP1572962.
JD370718 - Sequence 351742 from Patent EP1572962.
BC156414 - Synthetic construct Homo sapiens clone IMAGE:100062940, MGC:190643 jumonji domain containing 1C (JMJD1C) mRNA, encodes complete protein.
AK024991 - Homo sapiens cDNA: FLJ21338 fis, clone COL02572.
L40411 - Homo sapiens thyroid receptor interactor (TRIP8) mRNA, 3' end of cds.
AK056660 - Homo sapiens cDNA FLJ32098 fis, clone OCBBF2001124, weakly similar to TESTIS SPECIFIC PROTEIN A.
AK095584 - Homo sapiens cDNA FLJ38265 fis, clone FCBBF3001855, weakly similar to Homo sapiens zinc finger protein mRNA.
BC026268 - Homo sapiens jumonji domain containing 1C, mRNA (cDNA clone IMAGE:4703438), partial cds.
AK126040 - Homo sapiens cDNA FLJ44052 fis, clone TESTI4033690.
JD528738 - Sequence 509762 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: BX537954
UCSC ID: uc009xpj.2
RefSeq Accession: NM_004241

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: yes RNA accession: BX537954.1
exon count: 22CDS single in 3' UTR: no RNA size: 8015
ORF size: 0CDS single in intron: no Alignment % ID: 99.89
txCdsPredict score: 8487.50frame shift in genome: no % Coverage: 99.78
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.