Human Gene TRIM69 (uc010bdy.1) Description and Page Index
  Description: Homo sapiens tripartite motif containing 69 (TRIM69), transcript variant b, mRNA.
RefSeq Summary (NM_080745): This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr15:45,028,540-45,060,025 Size: 31,486 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr15:45,050,852-45,059,970 Size: 9,119 Coding Exon Count: 4 

Page IndexSequence and LinksGenetic AssociationsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr15:45,028,540-45,060,025)mRNA (may differ from genome)Protein (279 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
Stanford SOURCEUniProtKB

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TRIM69
CDC HuGE Published Literature: TRIM69
Positive Disease Associations: monocyte chemoattractant protein 1 (66-77)
Related Studies:
  1. monocyte chemoattractant protein 1 (66-77)
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.76 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 192.84 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -148.35506-0.293 Picture PostScript Text
3' UTR -2.1055-0.038 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00622 - SPRY domain
PF13765 - SPRY-associated domain

ModBase Predicted Comparative 3D Structure on Q86WT6-4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Descriptions from all associated GenBank mRNAs
  DQ232883 - Homo sapiens tripartite motif protein 69 (TRIM69) mRNA, complete cds.
AK292252 - Homo sapiens cDNA FLJ76057 complete cds, highly similar to Homo sapiens ring finger protein 36, transcript variant a, mRNA.
BC047945 - Homo sapiens tripartite motif-containing 69, mRNA (cDNA clone MGC:50818 IMAGE:5744224), complete cds.
AL360161 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1621663.
AF302088 - Homo sapiens TRIMLESS alpha (TRIMLESS) mRNA, complete cds.
AF302089 - Homo sapiens TRIMLESS beta (TRIMLESS) mRNA, complete cds.
JD131568 - Sequence 112592 from Patent EP1572962.
JD247448 - Sequence 228472 from Patent EP1572962.
JD152656 - Sequence 133680 from Patent EP1572962.
JD559463 - Sequence 540487 from Patent EP1572962.
BC024199 - Homo sapiens tripartite motif-containing 69, mRNA (cDNA clone IMAGE:4822946), partial cds.
JD464742 - Sequence 445766 from Patent EP1572962.
JD150701 - Sequence 131725 from Patent EP1572962.
JD254538 - Sequence 235562 from Patent EP1572962.
JD133697 - Sequence 114721 from Patent EP1572962.
JD154902 - Sequence 135926 from Patent EP1572962.
BC033314 - Homo sapiens tripartite motif-containing 69, mRNA (cDNA clone MGC:35082 IMAGE:5166812), complete cds.
JD111230 - Sequence 92254 from Patent EP1572962.
JD226707 - Sequence 207731 from Patent EP1572962.
JD174161 - Sequence 155185 from Patent EP1572962.
JD104217 - Sequence 85241 from Patent EP1572962.
JD400127 - Sequence 381151 from Patent EP1572962.
AY305385 - Homo sapiens HSD-34 mRNA, complete cds.
JD512091 - Sequence 493115 from Patent EP1572962.
AK226115 - Homo sapiens mRNA for ring finger protein 36 isoform a variant, clone: hh00788.
CU689624 - Synthetic construct Homo sapiens gateway clone IMAGE:100019011 5' read TRIM69 mRNA.
EU446573 - Synthetic construct Homo sapiens clone IMAGE:100070084; IMAGE:100011782; FLH257457.01L tripartite motif-containing 69 (TRIM69) gene, encodes complete protein.
EU832108 - Synthetic construct Homo sapiens clone HAIB:100067137; DKFZo008B1025 tripartite motif-containing 69 protein (TRIM69) gene, encodes complete protein.
EU832202 - Synthetic construct Homo sapiens clone HAIB:100067231; DKFZo004B1026 tripartite motif-containing 69 protein (TRIM69) gene, encodes complete protein.
KJ895549 - Synthetic construct Homo sapiens clone ccsbBroadEn_04943 TRIM69 gene, encodes complete protein.
JD419063 - Sequence 400087 from Patent EP1572962.
JD248124 - Sequence 229148 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q86WT6 (Reactome details) participates in the following event(s):

R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex
R-HSA-983147 Release of E3 from polyubiquitinated substrate
R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
R-HSA-983169 Class I MHC mediated antigen processing & presentation
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: AF302089, HSD-34, HSD34, Q86WT6-4, RNF36
UCSC ID: uc010bdy.1
RefSeq Accession: NM_080745
Protein: Q86WT6-4, splice isoform of Q86WT6

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: AF302089.1
exon count: 6CDS single in 3' UTR: no RNA size: 1231
ORF size: 840CDS single in intron: no Alignment % ID: 99.92
txCdsPredict score: 1622.50frame shift in genome: no % Coverage: 98.46
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.