Human Gene MORF4L1 (uc010blj.2) Description and Page Index
  Description: Homo sapiens mortality factor 4 like 1 (MORF4L1), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr15:79,165,123-79,185,360 Size: 20,238 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr15:79,165,360-79,184,664 Size: 19,305 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr15:79,165,123-79,185,360)mRNA (may differ from genome)Protein (155 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=Mortality factor 4-like protein 1;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): MORF4L1
CDC HuGE Published Literature: MORF4L1
Positive Disease Associations: Heart Rate
Related Studies:
  1. Heart Rate
    , , . [PubMed 0]

-  MalaCards Disease Associations
  MalaCards Gene Search: MORF4L1
Diseases sorted by gene-association score: paraneoplastic cerebellar degeneration (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 111.42 RPKM in Testis
Total median expression: 3130.37 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -103.60237-0.437 Picture PostScript Text
3' UTR -174.20696-0.250 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000953 - Chromo_domain/shadow
IPR016197 - Chromodomain-like
IPR017398 - EAF3/MRG15
IPR008676 - MRG
IPR026541 - MRG_dom
IPR025995 - Tudor-knot

Pfam Domains:
PF05712 - MRG
PF11717 - RNA binding activity-knot of a chromodomain

ModBase Predicted Comparative 3D Structure on H0YLJ3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0006325 chromatin organization
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0005634 nucleus
GO:0016580 Sin3 complex
GO:0035267 NuA4 histone acetyltransferase complex

-  Descriptions from all associated GenBank mRNAs
  AK095823 - Homo sapiens cDNA FLJ38504 fis, clone HCHON2000156, highly similar to Mortality factor 4-like protein 1.
AK098485 - Homo sapiens cDNA FLJ25619 fis, clone STM02419, highly similar to TRANSCRIPTION FACTOR-LIKE PROTEIN MORF4.
AF218011 - Homo sapiens clone PP368 unknown mRNA.
AF100615 - Homo sapiens chromosome 15 MRG15 protein (MRG15) mRNA, complete cds.
AY148481 - Homo sapiens putative transcription factor MRG15-2 (MRG15) mRNA, complete cds; alternatively spliced.
AK296650 - Homo sapiens cDNA FLJ50561 complete cds, highly similar to Mortality factor 4-like protein 1.
BC002936 - Homo sapiens mortality factor 4 like 1, mRNA (cDNA clone MGC:10631 IMAGE:3955120), complete cds.
BC022845 - Homo sapiens mortality factor 4 like 1, mRNA (cDNA clone MGC:1262 IMAGE:2988803), complete cds.
AK310702 - Homo sapiens cDNA, FLJ17744.
BC141840 - Homo sapiens mortality factor 4 like 1, mRNA (cDNA clone MGC:166970 IMAGE:8860303), complete cds.
AF070664 - Homo sapiens HSPC008 mRNA, complete cds.
AF167173 - Homo sapiens chromosome X MSL3-1 protein mRNA, complete cds.
AK310592 - Homo sapiens cDNA, FLJ17634.
AL137697 - Homo sapiens mRNA; cDNA DKFZp566F194 (from clone DKFZp566F194).
AF109188 - Homo sapiens FWP006 mRNA, complete cds.
AF161546 - Homo sapiens HSPC061 mRNA, complete cds.
AK300789 - Homo sapiens cDNA FLJ50694 complete cds, highly similar to Mortality factor 4-like protein 1.
BC067826 - Homo sapiens mortality factor 4 like 1, mRNA (cDNA clone MGC:87361 IMAGE:4824022), complete cds.
CU692730 - Synthetic construct Homo sapiens gateway clone IMAGE:100018923 5' read MORF4L1 mRNA.
AB385578 - Synthetic construct DNA, clone: pF1KB9446, Homo sapiens MORF4L1 gene for mortality factor 4-like protein 1, complete cds, without stop codon, in Flexi system.
DQ892602 - Synthetic construct clone IMAGE:100005232; FLH188135.01X; RZPDo839G10150D mortality factor 4 like 1 (MORF4L1) gene, encodes complete protein.
DQ895837 - Synthetic construct Homo sapiens clone IMAGE:100010297; FLH188131.01L; RZPDo839G10149D mortality factor 4 like 1 (MORF4L1) gene, encodes complete protein.
KJ893172 - Synthetic construct Homo sapiens clone ccsbBroadEn_02566 MORF4L1 gene, encodes complete protein.
AK310181 - Homo sapiens cDNA, FLJ17223.
JD024428 - Sequence 5452 from Patent EP1572962.
JD029863 - Sequence 10887 from Patent EP1572962.
JD025067 - Sequence 6091 from Patent EP1572962.
JD047852 - Sequence 28876 from Patent EP1572962.
JD034132 - Sequence 15156 from Patent EP1572962.
JD485891 - Sequence 466915 from Patent EP1572962.
JD215540 - Sequence 196564 from Patent EP1572962.
JD292630 - Sequence 273654 from Patent EP1572962.
AF131847 - Homo sapiens clone 24896 mRNA sequence, partial cds.
KJ904665 - Synthetic construct Homo sapiens clone ccsbBroadEn_14059 MORF4 gene, encodes complete protein.
KJ906062 - Synthetic construct Homo sapiens clone ccsbBroadEn_15732 MORF4L1 gene, encodes complete protein.
BC121092 - Homo sapiens mortality factor 4 like 1, mRNA (cDNA clone MGC:150374 IMAGE:40119977), complete cds.
BC121093 - Homo sapiens mortality factor 4 like 1, mRNA (cDNA clone MGC:150375 IMAGE:40119978), complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: AK310702, H0YLJ3, H0YLJ3_HUMAN, uc010blj.1
UCSC ID: uc010blj.2
RefSeq Accession: NM_006791
Protein: H0YLJ3

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: AK310702.1
exon count: 7CDS single in 3' UTR: no RNA size: 1209
ORF size: 468CDS single in intron: no Alignment % ID: 99.92
txCdsPredict score: 1130.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 705# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.