Human Gene CABIN1 (uc010gul.1) Description and Page Index
Description: Homo sapiens calcineurin binding protein 1 (CABIN1), transcript variant 3, mRNA. RefSeq Summary (NM_001201429): Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms. [provided by RefSeq, Jan 2011]. Transcript (Including UTRs) Position: hg19 chr22:24,567,681-24,574,596 Size: 6,916 Total Exon Count: 3 Strand: + Coding Region Position: hg19 chr22:24,567,945-24,574,164 Size: 6,220 Coding Exon Count: 3
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.