Human Gene SEC14L2 (uc010gvv.3) Description and Page Index
  Description: Homo sapiens SEC14-like 2 (S. cerevisiae) (SEC14L2), transcript variant 3, mRNA.
RefSeq Summary (NM_001204204): This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008].
Transcript (Including UTRs)
   Position: hg19 chr22:30,805,176-30,821,291 Size: 16,116 Total Exon Count: 7 Strand: +


Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionOther SpeciesmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:30,805,176-30,821,291)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerH-INVHGNCLynx
PubMedStanford SOURCETreefamWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): SEC14L2
CDC HuGE Published Literature: SEC14L2
Positive Disease Associations: Waist Circumference
Related Studies:
  1. Waist Circumference
    , , . [PubMed 0]

-  MalaCards Disease Associations
  MalaCards Gene Search: SEC14L2
Diseases sorted by gene-association score: retinitis pigmentosa 41 (4), ataxia with isolated vitamin e deficiency (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 32.42 RPKM in Liver
Total median expression: 209.46 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AL096881 - Novel human mRNA similar to Rattus norvegicus 45 kDa secretory protein, AJ132352.
AK223587 - Homo sapiens mRNA for SEC14-like 2 variant, clone: FCC130E01.
BC048337 - Homo sapiens SEC14-like 2 (S. cerevisiae), mRNA (cDNA clone IMAGE:5212661), partial cds.
AK314390 - Homo sapiens cDNA, FLJ95164, highly similar to Homo sapiens SEC14-like 2 (S. cerevisiae) (SEC14L2), mRNA.
AK091402 - Homo sapiens cDNA FLJ34083 fis, clone FCBBF3004409, highly similar to SEC14-like protein 2.
BC058915 - Homo sapiens SEC14-like 2 (S. cerevisiae), mRNA (cDNA clone MGC:65053 IMAGE:5178251), complete cds.
AB033012 - Homo sapiens KIAA1186 mRNA for KIAA1186 protein.
CR456571 - Homo sapiens SEC14L2 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.SEC14L2).
AK303751 - Homo sapiens cDNA FLJ53690 complete cds, highly similar to SEC14-like protein 2.
AK296540 - Homo sapiens cDNA FLJ54104 complete cds, highly similar to SEC14-like protein 2.
CU013458 - Homo sapiens SEC14L2, mRNA (cDNA clone IMAGE:100000428), complete cds, without stop codon, in Gateway system.
CU013170 - Homo sapiens SEC14L2, mRNA (cDNA clone IMAGE:100000524), complete cds, with stop codon, in Gateway system.
AB384131 - Synthetic construct DNA, clone: pF1KSDA1186, Homo sapiens SEC14L2 gene for SEC14-like protein 2, complete cds, without stop codon, in Flexi system.
AY927438 - Homo sapiens mRNA sequence.
AY927439 - Homo sapiens mRNA sequence.
AK056163 - Homo sapiens cDNA FLJ31601 fis, clone NT2RI2002592.
AY927434 - Homo sapiens mRNA sequence.
AY927435 - Homo sapiens mRNA sequence.
AY927436 - Homo sapiens mRNA sequence.
AY927437 - Homo sapiens mRNA sequence.
AY927441 - Homo sapiens mRNA sequence.
AY927432 - Homo sapiens mRNA sequence.
AY927433 - Homo sapiens mRNA sequence.
AY927440 - Homo sapiens mRNA sequence.
AY927431 - Homo sapiens mRNA sequence.
AY927442 - Homo sapiens mRNA sequence.
AK092576 - Homo sapiens cDNA FLJ35257 fis, clone PROST2004115.
JD298055 - Sequence 279079 from Patent EP1572962.
JD158085 - Sequence 139109 from Patent EP1572962.
JD469975 - Sequence 450999 from Patent EP1572962.
JD288222 - Sequence 269246 from Patent EP1572962.
JD448800 - Sequence 429824 from Patent EP1572962.
AY203959 - Homo sapiens LP6347 mRNA, complete cds.
JD508088 - Sequence 489112 from Patent EP1572962.
JD053371 - Sequence 34395 from Patent EP1572962.
JD266698 - Sequence 247722 from Patent EP1572962.
JD101768 - Sequence 82792 from Patent EP1572962.
JD565509 - Sequence 546533 from Patent EP1572962.
JD257242 - Sequence 238266 from Patent EP1572962.
JD371804 - Sequence 352828 from Patent EP1572962.
JD338691 - Sequence 319715 from Patent EP1572962.
JD453244 - Sequence 434268 from Patent EP1572962.
JD218929 - Sequence 199953 from Patent EP1572962.
JD493466 - Sequence 474490 from Patent EP1572962.
JD350765 - Sequence 331789 from Patent EP1572962.
JD380191 - Sequence 361215 from Patent EP1572962.
JD222413 - Sequence 203437 from Patent EP1572962.
JD231309 - Sequence 212333 from Patent EP1572962.
JD437109 - Sequence 418133 from Patent EP1572962.
JD216009 - Sequence 197033 from Patent EP1572962.
JD462224 - Sequence 443248 from Patent EP1572962.
JD341840 - Sequence 322864 from Patent EP1572962.
JD102505 - Sequence 83529 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AY927434
UCSC ID: uc010gvv.3
RefSeq Accession: NM_001204204

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: no RNA accession: AY927434.1
exon count: 7CDS single in 3' UTR: no RNA size: 552
ORF size: 0CDS single in intron: no Alignment % ID: 99.82
txCdsPredict score: 364.00frame shift in genome: no % Coverage: 99.46
has start codon: no stop codon in genome: no # of Alignments: 1
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.