Human Gene ZBTB38 (uc010hun.3) Description and Page Index
Description: Homo sapiens zinc finger and BTB domain containing 38 (ZBTB38), mRNA. RefSeq Summary (NM_001080412): The protein encoded by this gene is a zinc finger transcriptional activator that binds methylated DNA. The encoded protein can form homodimers or heterodimers through the zinc finger domains. In mouse, inhibition of this protein has been associated with apoptosis in some cell types. [provided by RefSeq, Jun 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC015444.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## Transcript (Including UTRs) Position: hg19 chr3:141,106,489-141,168,632 Size: 62,144 Total Exon Count: 4 Strand: + Coding Region Position: hg19 chr3:141,161,240-141,164,818 Size: 3,579 Coding Exon Count: 1
ID:ZBT38_HUMAN DESCRIPTION: RecName: Full=Zinc finger and BTB domain-containing protein 38; FUNCTION: Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). POLYMORPHISM: Genetic variations in ZBTB38 define the stature quantitative trait locus 10 (STQTL10) [MIM:612221]. Adult height is an easily observable and highly heritable complex continuous trait. Because of this, it is a model trait for studying genetic influence on quantitative traits. SIMILARITY: Contains 1 BTB (POZ) domain. SIMILARITY: Contains 10 C2H2-type zinc fingers. SEQUENCE CAUTION: Sequence=BAC03868.1; Type=Frameshift; Positions=147;
Genetic Association Studies of Complex Diseases and Disorders
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8NAP3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006275 regulation of DNA replication GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006974 cellular response to DNA damage stimulus GO:0045892 negative regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter