Human Gene CEP57L1 (uc010kdk.3) Description and Page Index
  Description: Homo sapiens centrosomal protein 57kDa-like 1 (CEP57L1), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr6:109,416,356-109,485,115 Size: 68,760 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg19 chr6:109,466,425-109,484,173 Size: 17,749 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:109,416,356-109,485,115)mRNA (may differ from genome)Protein (460 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
PubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: CE57L_HUMAN
DESCRIPTION: RecName: Full=Centrosomal protein CEP57L1; AltName: Full=Centrosomal protein 57kDa-like protein 1; AltName: Full=Centrosomal protein of 57 kDa-related protein; Short=Cep57R; AltName: Full=Cep57-related protein;
FUNCTION: Centrosomal protein which may be required for microtubule attachment to centrosomes (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome (By similarity).
SIMILARITY: Belongs to the translokin family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.14 RPKM in Testis
Total median expression: 63.32 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -186.60577-0.323 Picture PostScript Text
3' UTR -197.52942-0.210 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR010597 - Centrosomal_protein_57kDa
IPR025913 - Cep57_CLD
IPR024957 - Cep57_MT-bd_dom

Pfam Domains:
PF06657 - Centrosome microtubule-binding domain of Cep57
PF14073 - Centrosome localisation domain of Cep57

ModBase Predicted Comparative 3D Structure on Q8IYX8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0042802 identical protein binding
GO:0043015 gamma-tubulin binding

Biological Process:
GO:0000070 mitotic sister chromatid segregation
GO:0008150 biological_process

Cellular Component:
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005856 cytoskeleton
GO:0005874 microtubule


-  Descriptions from all associated GenBank mRNAs
  BC064365 - Homo sapiens chromosome 6 open reading frame 182, mRNA (cDNA clone MGC:70837 IMAGE:5558124), complete cds.
AK092723 - Homo sapiens cDNA FLJ35404 fis, clone SKNSH2006822.
AX747690 - Sequence 1215 from Patent EP1308459.
AK289910 - Homo sapiens cDNA FLJ75975 complete cds.
HQ447957 - Synthetic construct Homo sapiens clone IMAGE:100071319; CCSB002621_03 chromosome 6 open reading frame 182 (C6orf182) gene, encodes complete protein.
KJ896013 - Synthetic construct Homo sapiens clone ccsbBroadEn_05407 CEP57L1 gene, encodes complete protein.
KJ905072 - Synthetic construct Homo sapiens clone ccsbBroadEn_14466 CEP57L1 gene, encodes complete protein.
BC033448 - Homo sapiens chromosome 6 open reading frame 182, mRNA (cDNA clone MGC:21731 IMAGE:4514050), complete cds.
CU687862 - Synthetic construct Homo sapiens gateway clone IMAGE:100021645 5' read C6orf182 mRNA.
CU689626 - Synthetic construct Homo sapiens gateway clone IMAGE:100018313 5' read C6orf182 mRNA.
AK094192 - Homo sapiens cDNA FLJ36873 fis, clone ASTRO2017627.
AK027189 - Homo sapiens cDNA: FLJ23536 fis, clone LNG07557.
JD072642 - Sequence 53666 from Patent EP1572962.
JD062548 - Sequence 43572 from Patent EP1572962.
JD503857 - Sequence 484881 from Patent EP1572962.
JD225983 - Sequence 207007 from Patent EP1572962.
JD131978 - Sequence 113002 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: C6orf182, CE57L_HUMAN, CEP57R, NM_001083535, NP_776191, Q8IYX8
UCSC ID: uc010kdk.3
RefSeq Accession: NM_001083535
Protein: Q8IYX8 (aka CE57L_HUMAN)
CCDS: CCDS5071.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001083535.1
exon count: 13CDS single in 3' UTR: no RNA size: 2915
ORF size: 1383CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2790.00frame shift in genome: no % Coverage: 99.55
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.