Human Gene NCOA7 (uc010kes.3) Description and Page Index
  Description: Homo sapiens nuclear receptor coactivator 7 (NCOA7), transcript variant 4, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr6:126,102,307-126,253,176 Size: 150,870 Total Exon Count: 18 Strand: +
Coding Region
   Position: hg19 chr6:126,136,501-126,249,917 Size: 113,417 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:126,102,307-126,253,176)mRNA (may differ from genome)Protein (942 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCLynxMGIneXtProtOMIM
PubMedStanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: NCOA7_HUMAN
DESCRIPTION: RecName: Full=Nuclear receptor coactivator 7; AltName: Full=140 kDa estrogen receptor-associated protein; AltName: Full=Estrogen nuclear receptor coactivator 1;
FUNCTION: Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA.
SUBUNIT: Interacts with ESR1, ESR2A, ESR2B, THRB, PPARG and RARA in a ligand-inducible manner. Interacts with the heterodimer AHR- ARNT.
INTERACTION: P35869:AHR; NbExp=2; IntAct=EBI-80799, EBI-80780; P27540:ARNT; NbExp=2; IntAct=EBI-80799, EBI-80809; O95166:GABARAP; NbExp=4; IntAct=EBI-80799, EBI-712001; Q9H0R8:GABARAPL1; NbExp=2; IntAct=EBI-80799, EBI-746969;
SUBCELLULAR LOCATION: Nucleus (Probable).
TISSUE SPECIFICITY: Highly expressed in brain. Weakly expressed in mammary gland, ovary, uterus, prostate, stomach, bladder, spinal cord and pancreas. Expressed in cancer cell line.
SIMILARITY: Belongs to the OXR1 family.
SIMILARITY: Contains 1 LysM repeat.
SIMILARITY: Contains 1 TLD domain.
SEQUENCE CAUTION: Sequence=CAD89948.1; Type=Frameshift; Positions=782;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): NCOA7
CDC HuGE Published Literature: NCOA7
Positive Disease Associations: Cholesterol, HDL , Forced Vital Capacity , Heart Failure , Sleep
Related Studies:
  1. Cholesterol, HDL
    Sekar Kathiresan et al. BMC medical genetics 2007, A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study., BMC medical genetics. [PubMed 17903299]
    Using a 100K genome-wide scan, we have generated a set of putative associations for common sequence variants and lipid phenotypes. Validation of selected hypotheses in additional samples did not identify any new loci underlying variability in blood lipids. Lack of replication may be due to inadequate statistical power to detect modest quantitative trait locus effects (i.e., <1% of trait variance explained) or reduced genomic coverage of the 100K array. GWAS in FHS using a denser genome-wide genotyping platform and a better-powered replication strategy may identify novel loci underlying blood lipids.
  2. Forced Vital Capacity
    , , . [PubMed 0]
  3. Forced Vital Capacity
    , , . [PubMed 0]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: NCOA7
Diseases sorted by gene-association score: brugada syndrome (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 18.09 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 371.87 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -124.49470-0.265 Picture PostScript Text
3' UTR -825.093259-0.253 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004182 - GRAM
IPR018392 - Peptidoglycan-bd_lysin
IPR002482 - Peptidoglycan-bd_Lysin_subgr
IPR006571 - TLDc

Pfam Domains:
PF01476 - LysM domain
PF07534 - TLD

SCOP Domains:
54106 - LysM domain

ModBase Predicted Comparative 3D Structure on Q8NI08
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0035257 nuclear hormone receptor binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:1900408 negative regulation of cellular response to oxidative stress
GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation
GO:1903204 negative regulation of oxidative stress-induced neuron death

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AF493978 - Homo sapiens 140 kDa estrogen receptor associated protein mRNA, complete cds.
BC137094 - Homo sapiens nuclear receptor coactivator 7, mRNA (cDNA clone MGC:168714 IMAGE:9021091), complete cds.
BC137095 - Homo sapiens nuclear receptor coactivator 7, mRNA (cDNA clone MGC:168715 IMAGE:9021092), complete cds.
AK127512 - Homo sapiens cDNA FLJ45605 fis, clone BRTHA3021971, highly similar to Nuclear receptor coactivator 7.
AK294558 - Homo sapiens cDNA FLJ53471 complete cds, highly similar to Nuclear receptor coactivator 7.
BX537385 - Homo sapiens mRNA; cDNA DKFZp686O06111 (from clone DKFZp686O06111); complete cds.
AL832621 - Homo sapiens mRNA; cDNA DKFZp451P0217 (from clone DKFZp451P0217).
AL832628 - Homo sapiens mRNA; cDNA DKFZp451D1618 (from clone DKFZp451D1618).
AM393179 - Synthetic construct Homo sapiens clone IMAGE:100002320 for hypothetical protein (NCOA7 gene).
AM393484 - Synthetic construct Homo sapiens clone IMAGE:100002733 for hypothetical protein (NCOA7 gene).
AM392895 - Synthetic construct Homo sapiens clone IMAGE:100002981 for hypothetical protein (NCOA7 gene).
AM393507 - Synthetic construct Homo sapiens clone IMAGE:100002980 for hypothetical protein (NCOA7 gene).
AM393871 - Synthetic construct Homo sapiens clone IMAGE:100002979 for hypothetical protein (NCOA7 gene).
AL834442 - Homo sapiens mRNA; cDNA DKFZp761B2210 (from clone DKFZp761B2210).
BC033612 - Homo sapiens nuclear receptor coactivator 7, mRNA (cDNA clone IMAGE:4997115), partial cds.
AJ420542 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1090104.
AK307395 - Homo sapiens cDNA, FLJ97343.
BC036461 - Homo sapiens nuclear receptor coactivator 7, mRNA (cDNA clone IMAGE:4818332), complete cds.
AB074157 - Homo sapiens primary neuroblastoma cDNA, clone:Nbla10993, full insert sequence.
AB074156 - Homo sapiens primary neuroblastoma cDNA, clone:Nbla00052, full insert sequence.
BC071782 - Homo sapiens nuclear receptor coactivator 7, mRNA (cDNA clone IMAGE:4609474), complete cds.
KJ903788 - Synthetic construct Homo sapiens clone ccsbBroadEn_13182 NCOA7 gene, encodes complete protein.
LF322086 - JP 2014500723-A/129589: Polycomb-Associated Non-Coding RNAs.
LF322083 - JP 2014500723-A/129586: Polycomb-Associated Non-Coding RNAs.
BC009399 - Homo sapiens nuclear receptor coactivator 7, mRNA (cDNA clone IMAGE:4132089), partial cds.
LF322080 - JP 2014500723-A/129583: Polycomb-Associated Non-Coding RNAs.
LF322079 - JP 2014500723-A/129582: Polycomb-Associated Non-Coding RNAs.
MA557663 - JP 2018138019-A/129589: Polycomb-Associated Non-Coding RNAs.
MA557660 - JP 2018138019-A/129586: Polycomb-Associated Non-Coding RNAs.
MA557657 - JP 2018138019-A/129583: Polycomb-Associated Non-Coding RNAs.
MA557656 - JP 2018138019-A/129582: Polycomb-Associated Non-Coding RNAs.
AY364254 - Homo sapiens clone peg2403 hypothetical protein mRNA, partial cds.
LF322072 - JP 2014500723-A/129575: Polycomb-Associated Non-Coding RNAs.
LF322071 - JP 2014500723-A/129574: Polycomb-Associated Non-Coding RNAs.
KC238672 - Homo sapiens NCOA7-AS (NCOA7) mRNA, complete cds.
AK094706 - Homo sapiens cDNA FLJ37387 fis, clone BRAMY2026685, moderately similar to Homo sapiens oxidation protection protein (OXR1) mRNA.
JD500564 - Sequence 481588 from Patent EP1572962.
JD190713 - Sequence 171737 from Patent EP1572962.
JD335254 - Sequence 316278 from Patent EP1572962.
JD290737 - Sequence 271761 from Patent EP1572962.
JD091710 - Sequence 72734 from Patent EP1572962.
JD428797 - Sequence 409821 from Patent EP1572962.
JD094334 - Sequence 75358 from Patent EP1572962.
JD171858 - Sequence 152882 from Patent EP1572962.
JD327966 - Sequence 308990 from Patent EP1572962.
JD357255 - Sequence 338279 from Patent EP1572962.
JD548749 - Sequence 529773 from Patent EP1572962.
JD321317 - Sequence 302341 from Patent EP1572962.
JD556994 - Sequence 538018 from Patent EP1572962.
BC039853 - Homo sapiens nuclear receptor coactivator 7, mRNA (cDNA clone IMAGE:5738565), with apparent retained intron.
JD306747 - Sequence 287771 from Patent EP1572962.
JD118732 - Sequence 99756 from Patent EP1572962.
JD110557 - Sequence 91581 from Patent EP1572962.
JD110558 - Sequence 91582 from Patent EP1572962.
JD454123 - Sequence 435147 from Patent EP1572962.
JD347050 - Sequence 328074 from Patent EP1572962.
JD376122 - Sequence 357146 from Patent EP1572962.
JD404886 - Sequence 385910 from Patent EP1572962.
JD536211 - Sequence 517235 from Patent EP1572962.
JD179209 - Sequence 160233 from Patent EP1572962.
JD376819 - Sequence 357843 from Patent EP1572962.
JD482993 - Sequence 464017 from Patent EP1572962.
JD135689 - Sequence 116713 from Patent EP1572962.
JD238033 - Sequence 219057 from Patent EP1572962.
JD047484 - Sequence 28508 from Patent EP1572962.
JD530830 - Sequence 511854 from Patent EP1572962.
JD171593 - Sequence 152617 from Patent EP1572962.
JD047855 - Sequence 28879 from Patent EP1572962.
JD086270 - Sequence 67294 from Patent EP1572962.
JD096468 - Sequence 77492 from Patent EP1572962.
JD308953 - Sequence 289977 from Patent EP1572962.
JD332456 - Sequence 313480 from Patent EP1572962.
JD448484 - Sequence 429508 from Patent EP1572962.
JD352062 - Sequence 333086 from Patent EP1572962.
JD257683 - Sequence 238707 from Patent EP1572962.
JD144021 - Sequence 125045 from Patent EP1572962.
JD230101 - Sequence 211125 from Patent EP1572962.
JD433724 - Sequence 414748 from Patent EP1572962.
JD492851 - Sequence 473875 from Patent EP1572962.
LF322068 - JP 2014500723-A/129571: Polycomb-Associated Non-Coding RNAs.
JD244994 - Sequence 226018 from Patent EP1572962.
MA557649 - JP 2018138019-A/129575: Polycomb-Associated Non-Coding RNAs.
MA557648 - JP 2018138019-A/129574: Polycomb-Associated Non-Coding RNAs.
MA557645 - JP 2018138019-A/129571: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RNS2, B9EH71, ERAP140, ESNA1, Nbla00052, Nbla10993, NCOA7_HUMAN, NM_001199620, NP_861447, Q3LID6, Q4G0V1, Q5TF95, Q6IPQ4, Q6NE83, Q86T89, Q8N1W4, Q8NI08
UCSC ID: uc010kes.3
RefSeq Accession: NM_001199620
Protein: Q8NI08 (aka NCOA7_HUMAN)
CCDS: CCDS5132.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001199620.1
exon count: 18CDS single in 3' UTR: no RNA size: 6558
ORF size: 2829CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 5493.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.