Human Gene MTUS1 (uc010lsy.3) Description and Page Index
  Description: Homo sapiens microtubule associated tumor suppressor 1 (MTUS1), transcript variant 1, mRNA.
RefSeq Summary (NM_001001924): This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr8:17,501,303-17,613,470 Size: 112,168 Total Exon Count: 15 Strand: -


Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionOther SpeciesmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:17,501,303-17,613,470)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblExonPrimerGeneNetworkH-INV
HGNCLynxPubMedStanford SOURCETreefamWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): MTUS1
CDC HuGE Published Literature: MTUS1
Positive Disease Associations: Apolipoproteins E , Cholesterol, HDL , Cholesterol, LDL , Myocardial Infarction
Related Studies:
  1. Apolipoproteins E
    Sekar Kathiresan et al. BMC medical genetics 2007, A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study., BMC medical genetics. [PubMed 17903299]
    Using a 100K genome-wide scan, we have generated a set of putative associations for common sequence variants and lipid phenotypes. Validation of selected hypotheses in additional samples did not identify any new loci underlying variability in blood lipids. Lack of replication may be due to inadequate statistical power to detect modest quantitative trait locus effects (i.e., <1% of trait variance explained) or reduced genomic coverage of the 100K array. GWAS in FHS using a denser genome-wide genotyping platform and a better-powered replication strategy may identify novel loci underlying blood lipids.
  2. Cholesterol, HDL
    Sekar Kathiresan et al. BMC medical genetics 2007, A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study., BMC medical genetics. [PubMed 17903299]
    Using a 100K genome-wide scan, we have generated a set of putative associations for common sequence variants and lipid phenotypes. Validation of selected hypotheses in additional samples did not identify any new loci underlying variability in blood lipids. Lack of replication may be due to inadequate statistical power to detect modest quantitative trait locus effects (i.e., <1% of trait variance explained) or reduced genomic coverage of the 100K array. GWAS in FHS using a denser genome-wide genotyping platform and a better-powered replication strategy may identify novel loci underlying blood lipids.
  3. Cholesterol, LDL
    Sekar Kathiresan et al. BMC medical genetics 2007, A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study., BMC medical genetics. [PubMed 17903299]
    Using a 100K genome-wide scan, we have generated a set of putative associations for common sequence variants and lipid phenotypes. Validation of selected hypotheses in additional samples did not identify any new loci underlying variability in blood lipids. Lack of replication may be due to inadequate statistical power to detect modest quantitative trait locus effects (i.e., <1% of trait variance explained) or reduced genomic coverage of the 100K array. GWAS in FHS using a denser genome-wide genotyping platform and a better-powered replication strategy may identify novel loci underlying blood lipids.
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: MTUS1
Diseases sorted by gene-association score: hepatocellular carcinoma* (95)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.73 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 222.18 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  LF208094 - JP 2014500723-A/15597: Polycomb-Associated Non-Coding RNAs.
LF213941 - JP 2014500723-A/21444: Polycomb-Associated Non-Coding RNAs.
AL096842 - Homo sapiens mRNA; cDNA DKFZp586D1519 (from clone DKFZp586D1519).
AK125188 - Homo sapiens cDNA FLJ43198 fis, clone FEBRA2007544, highly similar to Homo sapiens mitochondrial tumor suppressor 1 (MTUS1), transcript variant 4, mRNA.
AB033114 - Homo sapiens mRNA for KIAA1288 protein, partial cds.
BC136320 - Homo sapiens mitochondrial tumor suppressor 1, mRNA (cDNA clone MGC:167930 IMAGE:9020307), complete cds.
BC171765 - Homo sapiens cDNA clone IMAGE:9054419, containing frame-shift errors.
AK304105 - Homo sapiens cDNA FLJ53273 complete cds, highly similar to Homo sapiens mitochondrial tumor suppressor 1 (MTUS1), transcript variant 2, mRNA.
AK294860 - Homo sapiens cDNA FLJ59507 complete cds, highly similar to Homo sapiens mitochondrial tumor suppressor 1 (MTUS1), transcript variant 4, mRNA.
BC007328 - Homo sapiens mitochondrial tumor suppressor 1, mRNA (cDNA clone IMAGE:3835953), partial cds.
AY363099 - Homo sapiens normal early placenta (NEP) mRNA, partial cds.
MA449518 - JP 2018138019-A/21444: Polycomb-Associated Non-Coding RNAs.
MA443671 - JP 2018138019-A/15597: Polycomb-Associated Non-Coding RNAs.
AF121259 - Homo sapiens transcription factor MTSG1 mRNA, complete cds.
AK026661 - Homo sapiens cDNA: FLJ23008 fis, clone LNG00455.
AK000172 - Homo sapiens cDNA FLJ20165 fis, clone COL09466.
BC033842 - Homo sapiens mitochondrial tumor suppressor 1, mRNA (cDNA clone IMAGE:3921139), complete cds.
BC098381 - Homo sapiens cDNA clone IMAGE:4819473, containing frame-shift errors.
BC142971 - Homo sapiens mitochondrial tumor suppressor 1, mRNA (cDNA clone IMAGE:8860393), complete cds.
JD260492 - Sequence 241516 from Patent EP1572962.
AK024357 - Homo sapiens cDNA FLJ14295 fis, clone PLACE1008426, weakly similar to RESTIN.
JD241017 - Sequence 222041 from Patent EP1572962.
BX648879 - Homo sapiens mRNA; cDNA DKFZp686F20243 (from clone DKFZp686F20243).
JD449898 - Sequence 430922 from Patent EP1572962.
AF394227 - Homo sapiens erythroid differentiation-related mRNA, 3' UTR.
JD341332 - Sequence 322356 from Patent EP1572962.
JD294826 - Sequence 275850 from Patent EP1572962.
JD234777 - Sequence 215801 from Patent EP1572962.
JD225724 - Sequence 206748 from Patent EP1572962.
JD372044 - Sequence 353068 from Patent EP1572962.
JD550472 - Sequence 531496 from Patent EP1572962.
JD325613 - Sequence 306637 from Patent EP1572962.
JD267189 - Sequence 248213 from Patent EP1572962.
LF372074 - JP 2014500723-A/179577: Polycomb-Associated Non-Coding RNAs.
JD381891 - Sequence 362915 from Patent EP1572962.
JD148889 - Sequence 129913 from Patent EP1572962.
JD240269 - Sequence 221293 from Patent EP1572962.
JD433016 - Sequence 414040 from Patent EP1572962.
JD244748 - Sequence 225772 from Patent EP1572962.
JD431482 - Sequence 412506 from Patent EP1572962.
JD279928 - Sequence 260952 from Patent EP1572962.
JD283508 - Sequence 264532 from Patent EP1572962.
JD061268 - Sequence 42292 from Patent EP1572962.
JD454319 - Sequence 435343 from Patent EP1572962.
JD486584 - Sequence 467608 from Patent EP1572962.
JD318448 - Sequence 299472 from Patent EP1572962.
JD046719 - Sequence 27743 from Patent EP1572962.
JD302164 - Sequence 283188 from Patent EP1572962.
JD350856 - Sequence 331880 from Patent EP1572962.
JD548842 - Sequence 529866 from Patent EP1572962.
AF293357 - Homo sapiens AT2 receptor-interacting protein 1 mRNA, complete cds.
JD246393 - Sequence 227417 from Patent EP1572962.
JD435114 - Sequence 416138 from Patent EP1572962.
AF086371 - Homo sapiens full length insert cDNA clone ZD67D11.
AK093875 - Homo sapiens cDNA FLJ36556 fis, clone TRACH2008891.
JD436221 - Sequence 417245 from Patent EP1572962.
JD404712 - Sequence 385736 from Patent EP1572962.
JD510141 - Sequence 491165 from Patent EP1572962.
AK289750 - Homo sapiens cDNA FLJ78313 complete cds, highly similar to Homo sapiens mitochondrial tumor suppressor 1 (MTUS1), transcript variant 5, mRNA.
JD353831 - Sequence 334855 from Patent EP1572962.
JD488306 - Sequence 469330 from Patent EP1572962.
AK314692 - Homo sapiens cDNA, FLJ95546, highly similar to Homo sapiens mitochondrial tumor suppressor gene 1 (MTSG1), mRNA.
KJ902960 - Synthetic construct Homo sapiens clone ccsbBroadEn_12354 MTUS1 gene, encodes complete protein.
BC140067 - Synthetic construct Homo sapiens clone IMAGE:100000873, MGC:167338 mitochondrial tumor suppressor 1 (MTUS1) mRNA, encodes complete protein.
BC140068 - Synthetic construct Homo sapiens clone IMAGE:100013629, MGC:167339 mitochondrial tumor suppressor 1 (MTUS1) mRNA, encodes complete protein.
KJ899344 - Synthetic construct Homo sapiens clone ccsbBroadEn_08738 MTUS1 gene, encodes complete protein.
LF372075 - JP 2014500723-A/179578: Polycomb-Associated Non-Coding RNAs.
LF372076 - JP 2014500723-A/179579: Polycomb-Associated Non-Coding RNAs.
LF372077 - JP 2014500723-A/179580: Polycomb-Associated Non-Coding RNAs.
BC017740 - Homo sapiens mitochondrial tumor suppressor 1, mRNA (cDNA clone IMAGE:4186190), with apparent retained intron.
LF372078 - JP 2014500723-A/179581: Polycomb-Associated Non-Coding RNAs.
LF372079 - JP 2014500723-A/179582: Polycomb-Associated Non-Coding RNAs.
BC117564 - Homo sapiens cDNA clone IMAGE:4402466.
MA607651 - JP 2018138019-A/179577: Polycomb-Associated Non-Coding RNAs.
MA607652 - JP 2018138019-A/179578: Polycomb-Associated Non-Coding RNAs.
MA607653 - JP 2018138019-A/179579: Polycomb-Associated Non-Coding RNAs.
MA607654 - JP 2018138019-A/179580: Polycomb-Associated Non-Coding RNAs.
MA607655 - JP 2018138019-A/179581: Polycomb-Associated Non-Coding RNAs.
MA607656 - JP 2018138019-A/179582: Polycomb-Associated Non-Coding RNAs.
AK310871 - Homo sapiens cDNA, FLJ17913.
LF372111 - JP 2014500723-A/179614: Polycomb-Associated Non-Coding RNAs.
LF372115 - JP 2014500723-A/179618: Polycomb-Associated Non-Coding RNAs.
LF372116 - JP 2014500723-A/179619: Polycomb-Associated Non-Coding RNAs.
LF372117 - JP 2014500723-A/179620: Polycomb-Associated Non-Coding RNAs.
LF372118 - JP 2014500723-A/179621: Polycomb-Associated Non-Coding RNAs.
MA607688 - JP 2018138019-A/179614: Polycomb-Associated Non-Coding RNAs.
MA607692 - JP 2018138019-A/179618: Polycomb-Associated Non-Coding RNAs.
MA607693 - JP 2018138019-A/179619: Polycomb-Associated Non-Coding RNAs.
MA607694 - JP 2018138019-A/179620: Polycomb-Associated Non-Coding RNAs.
MA607695 - JP 2018138019-A/179621: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: AL096842
UCSC ID: uc010lsy.3
RefSeq Accession: NM_001001924

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: yes RNA accession: AL096842.1
exon count: 15CDS single in 3' UTR: no RNA size: 5214
ORF size: 0CDS single in intron: no Alignment % ID: 99.96
txCdsPredict score: 4411.00frame shift in genome: no % Coverage: 99.69
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.