Human Gene KIF13B (uc010lvf.1) Description and Page Index
  Description: Homo sapiens kinesin family member 13B (KIF13B), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr8:29,006,094-29,120,610 Size: 114,517 Total Exon Count: 17 Strand: -
Coding Region
   Position: hg19 chr8:29,006,095-29,048,544 Size: 42,450 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:29,006,094-29,120,610)mRNA (may differ from genome)Protein (540 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblExonPrimerGeneCardsGeneNetwork
H-INVHGNCLynxMGIPubMedStanford SOURCE
UniProtKB

-  Comments and Description Text from UniProtKB
  ID: E7ERX9_HUMAN
DESCRIPTION: SubName: Full=Kinesin-like protein KIF13B;
SIMILARITY: Belongs to the kinesin-like protein family.
SIMILARITY: Contains 1 kinesin-motor domain.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): KIF13B
CDC HuGE Published Literature: KIF13B
Positive Disease Associations: C-Reactive Protein , Waist-Hip Ratio
Related Studies:
  1. C-Reactive Protein
    Emelia J Benjamin et al. BMC medical genetics 2007, Genome-wide association with select biomarker traits in the Framingham Heart Study., BMC medical genetics. [PubMed 17903293]
    The Framingham GWAS represents a resource to describe potentially novel genetic influences on systemic biomarker variability. The newly described associations will need to be replicated in other studies.
  2. Waist-Hip Ratio
    , , . [PubMed 0]

-  MalaCards Disease Associations
  MalaCards Gene Search: KIF13B
Diseases sorted by gene-association score: spastic paraplegia 37, autosomal dominant (13), spastic paraplegia 11, autosomal recessive (8), corticobasal degeneration (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 16.92 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 354.84 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -114.90351-0.327 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000253 - FHA_dom
IPR019821 - Kinesin_motor_CS
IPR001752 - Kinesin_motor_dom
IPR008984 - SMAD_FHA_domain

Pfam Domains:
PF00225 - Kinesin motor domain
PF00498 - FHA domain
PF16183 - Kinesin-associated
PF16796 - Microtubule binding

SCOP Domains:
49879 - SMAD/FHA domain
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on E7ERX9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003774 motor activity
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding

Biological Process:
GO:0007018 microtubule-based movement

Cellular Component:
GO:0005874 microtubule


-  Descriptions from all associated GenBank mRNAs
  AB014539 - Homo sapiens KIAA0639 mRNA for KIAA0639 protein.
AF279865 - Homo sapiens kinesin-like protein GAKIN mRNA, complete cds.
AB383932 - Synthetic construct DNA, clone: pF1KSDA0639, Homo sapiens KIF13B gene for kinesin family member 13B, complete cds, without stop codon, in Flexi system.
BC172411 - Synthetic construct Homo sapiens clone IMAGE:100069105, MGC:199116 kinesin family member 13B (KIF13B) mRNA, encodes complete protein.
AX721221 - Sequence 181 from Patent WO0220754.
BC051859 - Homo sapiens kinesin family member 13B, mRNA (cDNA clone IMAGE:5764383).
BC028056 - Homo sapiens kinesin family member 13B, mRNA (cDNA clone IMAGE:5115074), with apparent retained intron.
AK307848 - Homo sapiens cDNA, FLJ97796.
BC005977 - Homo sapiens kinesin family member 13B, mRNA (cDNA clone IMAGE:4103715), partial cds.
AK129580 - Homo sapiens cDNA FLJ26069 fis, clone PRS08323.

-  Other Names for This Gene
  Alternate Gene Symbols: BC028056, E7ERX9, E7ERX9_HUMAN
UCSC ID: uc010lvf.1
RefSeq Accession: NM_015254
Protein: E7ERX9

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC028056.1
exon count: 17CDS single in 3' UTR: no RNA size: 1789
ORF size: 1620CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3154.50frame shift in genome: no % Coverage: 98.66
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.