Human Gene MATN2 (uc010mbh.1) Description and Page Index
Description: Homo sapiens matrilin 2 (MATN2), transcript variant 1, mRNA. RefSeq Summary (NM_002380): This gene encodes a member of the von Willebrand factor A domain containing protein family. This family of proteins is thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This protein contains five von Willebrand factor A domains. The specific function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr8:98,881,311-99,045,887 Size: 164,577 Total Exon Count: 17 Strand: + Coding Region Position: hg19 chr8:98,900,329-99,045,886 Size: 145,558 Coding Exon Count: 16
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00092 - von Willebrand factor type A domain PF07645 - Calcium-binding EGF domain PF10393 - Trimeric coiled-coil oligomerisation domain of matrilin PF12661 - Human growth factor-like EGF PF12662 - Complement Clr-like EGF-like PF13519 - von Willebrand factor type A domain PF14670 - Coagulation Factor Xa inhibitory site
ModBase Predicted Comparative 3D Structure on O00339-3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.