Human Gene ERMP1 (uc010mhs.1) Description and Page Index
  Description: Homo sapiens endoplasmic reticulum metallopeptidase 1 (ERMP1), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr9:5,784,572-5,833,081 Size: 48,510 Total Exon Count: 14 Strand: -
Coding Region
   Position: hg19 chr9:5,787,144-5,811,279 Size: 24,136 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:5,784,572-5,833,081)mRNA (may differ from genome)Protein (518 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblExonPrimerGeneCardsGeneNetwork
H-INVHGNCLynxMGIneXtProtPubMed
Stanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ERMP1_HUMAN
DESCRIPTION: RecName: Full=Endoplasmic reticulum metallopeptidase 1; EC=3.4.-.-; AltName: Full=Felix-ina;
FUNCTION: Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures (By similarity).
COFACTOR: Binds 2 zinc ions per subunit (By similarity).
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the peptidase M28 family.
SEQUENCE CAUTION: Sequence=BAB15604.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.78 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 308.84 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -413.341084-0.381 Picture PostScript Text
3' UTR -753.752572-0.293 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007484 - Peptidase_M28

ModBase Predicted Comparative 3D Structure on Q7Z2K6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

Biological Process:
GO:0006508 proteolysis

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK127218 - Homo sapiens cDNA FLJ45285 fis, clone BRHIP3002000, highly similar to Rattus norvegicus endoplasmic reticulum metallopeptidase 1 (Ermp1), mRNA.
LF211300 - JP 2014500723-A/18803: Polycomb-Associated Non-Coding RNAs.
AL834191 - Homo sapiens mRNA; cDNA DKFZp762E096 (from clone DKFZp762E096).
AB058718 - Homo sapiens mRNA for KIAA1815 protein, partial cds.
JD565241 - Sequence 546265 from Patent EP1572962.
JD165908 - Sequence 146932 from Patent EP1572962.
JD514748 - Sequence 495772 from Patent EP1572962.
JD070966 - Sequence 51990 from Patent EP1572962.
JD049627 - Sequence 30651 from Patent EP1572962.
JD051924 - Sequence 32948 from Patent EP1572962.
LF345354 - JP 2014500723-A/152857: Polycomb-Associated Non-Coding RNAs.
JD548438 - Sequence 529462 from Patent EP1572962.
JD093572 - Sequence 74596 from Patent EP1572962.
AK026962 - Homo sapiens cDNA: FLJ23309 fis, clone HEP11618.
JD051918 - Sequence 32942 from Patent EP1572962.
LF345355 - JP 2014500723-A/152858: Polycomb-Associated Non-Coding RNAs.
JD228183 - Sequence 209207 from Patent EP1572962.
JD353882 - Sequence 334906 from Patent EP1572962.
JD212321 - Sequence 193345 from Patent EP1572962.
JD112910 - Sequence 93934 from Patent EP1572962.
JD065288 - Sequence 46312 from Patent EP1572962.
JD382537 - Sequence 363561 from Patent EP1572962.
JD444961 - Sequence 425985 from Patent EP1572962.
JD212047 - Sequence 193071 from Patent EP1572962.
JD280976 - Sequence 262000 from Patent EP1572962.
LF345356 - JP 2014500723-A/152859: Polycomb-Associated Non-Coding RNAs.
JD369392 - Sequence 350416 from Patent EP1572962.
JD214026 - Sequence 195050 from Patent EP1572962.
JD238700 - Sequence 219724 from Patent EP1572962.
JD083380 - Sequence 64404 from Patent EP1572962.
JD549553 - Sequence 530577 from Patent EP1572962.
JD300498 - Sequence 281522 from Patent EP1572962.
JD358521 - Sequence 339545 from Patent EP1572962.
JD386283 - Sequence 367307 from Patent EP1572962.
LF345357 - JP 2014500723-A/152860: Polycomb-Associated Non-Coding RNAs.
JD295121 - Sequence 276145 from Patent EP1572962.
JD565900 - Sequence 546924 from Patent EP1572962.
LF345358 - JP 2014500723-A/152861: Polycomb-Associated Non-Coding RNAs.
JD427980 - Sequence 409004 from Patent EP1572962.
JD090237 - Sequence 71261 from Patent EP1572962.
JD040577 - Sequence 21601 from Patent EP1572962.
JD539613 - Sequence 520637 from Patent EP1572962.
JD317123 - Sequence 298147 from Patent EP1572962.
JD491676 - Sequence 472700 from Patent EP1572962.
JD261774 - Sequence 242798 from Patent EP1572962.
JD455866 - Sequence 436890 from Patent EP1572962.
BC136771 - Homo sapiens endoplasmic reticulum metallopeptidase 1, mRNA (cDNA clone MGC:168384 IMAGE:9020761), complete cds.
BC136773 - Homo sapiens endoplasmic reticulum metallopeptidase 1, mRNA (cDNA clone MGC:168386 IMAGE:9020763), complete cds.
BC144404 - Homo sapiens cDNA clone IMAGE:9052925.
JD088078 - Sequence 69102 from Patent EP1572962.
JD527198 - Sequence 508222 from Patent EP1572962.
AK172831 - Homo sapiens cDNA FLJ23992 fis, clone HRC08583.
BC031630 - Homo sapiens endoplasmic reticulum metallopeptidase 1, mRNA (cDNA clone IMAGE:5170340), partial cds.
AK093217 - Homo sapiens cDNA FLJ35898 fis, clone TESTI2009520, highly similar to Rattus norvegicus endoplasmic reticulum metallopeptidase 1 (Ermp1), mRNA.
AX747995 - Sequence 1520 from Patent EP1308459.
JD119801 - Sequence 100825 from Patent EP1572962.
KJ903255 - Synthetic construct Homo sapiens clone ccsbBroadEn_12649 ERMP1 gene, encodes complete protein.
LF345359 - JP 2014500723-A/152862: Polycomb-Associated Non-Coding RNAs.
CU689210 - Synthetic construct Homo sapiens gateway clone IMAGE:100016695 5' read ERMP1 mRNA.
LF345360 - JP 2014500723-A/152863: Polycomb-Associated Non-Coding RNAs.
LF345362 - JP 2014500723-A/152865: Polycomb-Associated Non-Coding RNAs.
LF345364 - JP 2014500723-A/152867: Polycomb-Associated Non-Coding RNAs.
LF345365 - JP 2014500723-A/152868: Polycomb-Associated Non-Coding RNAs.
LF345366 - JP 2014500723-A/152869: Polycomb-Associated Non-Coding RNAs.
LF345367 - JP 2014500723-A/152870: Polycomb-Associated Non-Coding RNAs.
LF345370 - JP 2014500723-A/152873: Polycomb-Associated Non-Coding RNAs.
LF345373 - JP 2014500723-A/152876: Polycomb-Associated Non-Coding RNAs.
LF345375 - JP 2014500723-A/152878: Polycomb-Associated Non-Coding RNAs.
JD310906 - Sequence 291930 from Patent EP1572962.
JD244512 - Sequence 225536 from Patent EP1572962.
JD197534 - Sequence 178558 from Patent EP1572962.
JD039960 - Sequence 20984 from Patent EP1572962.
LF345388 - JP 2014500723-A/152891: Polycomb-Associated Non-Coding RNAs.
JD057479 - Sequence 38503 from Patent EP1572962.
JD409025 - Sequence 390049 from Patent EP1572962.
JD408164 - Sequence 389188 from Patent EP1572962.
LF345390 - JP 2014500723-A/152893: Polycomb-Associated Non-Coding RNAs.
JD129157 - Sequence 110181 from Patent EP1572962.
MA580931 - JP 2018138019-A/152857: Polycomb-Associated Non-Coding RNAs.
MA580932 - JP 2018138019-A/152858: Polycomb-Associated Non-Coding RNAs.
MA580933 - JP 2018138019-A/152859: Polycomb-Associated Non-Coding RNAs.
MA580934 - JP 2018138019-A/152860: Polycomb-Associated Non-Coding RNAs.
MA580935 - JP 2018138019-A/152861: Polycomb-Associated Non-Coding RNAs.
MA580936 - JP 2018138019-A/152862: Polycomb-Associated Non-Coding RNAs.
MA580937 - JP 2018138019-A/152863: Polycomb-Associated Non-Coding RNAs.
MA580939 - JP 2018138019-A/152865: Polycomb-Associated Non-Coding RNAs.
MA580941 - JP 2018138019-A/152867: Polycomb-Associated Non-Coding RNAs.
MA580942 - JP 2018138019-A/152868: Polycomb-Associated Non-Coding RNAs.
MA580943 - JP 2018138019-A/152869: Polycomb-Associated Non-Coding RNAs.
MA580944 - JP 2018138019-A/152870: Polycomb-Associated Non-Coding RNAs.
MA580947 - JP 2018138019-A/152873: Polycomb-Associated Non-Coding RNAs.
MA580950 - JP 2018138019-A/152876: Polycomb-Associated Non-Coding RNAs.
MA580952 - JP 2018138019-A/152878: Polycomb-Associated Non-Coding RNAs.
MA580965 - JP 2018138019-A/152891: Polycomb-Associated Non-Coding RNAs.
MA580967 - JP 2018138019-A/152893: Polycomb-Associated Non-Coding RNAs.
MA446877 - JP 2018138019-A/18803: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: AL834191, B2RNA4, ERMP1_HUMAN, FXNA, KIAA1815, Q7Z2K6, Q8N5T5, Q9H5M1
UCSC ID: uc010mhs.1
RefSeq Accession: NM_024896
Protein: Q7Z2K6 (aka ERMP1_HUMAN)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AL834191.1
exon count: 14CDS single in 3' UTR: no RNA size: 5008
ORF size: 1557CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2521.50frame shift in genome: no % Coverage: 99.30
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.