Human Gene ANKRD65 (uc010nyo.2) Description and Page Index
  Description: Homo sapiens ankyrin repeat domain 65 (ANKRD65), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr1:1,353,800-1,356,824 Size: 3,025 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr1:1,354,480-1,356,385 Size: 1,906 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:1,353,800-1,356,824)mRNA (may differ from genome)Protein (399 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtPubMedStanford SOURCE

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Ankyrin repeat domain-containing protein 65;
SIMILARITY: Contains 10 ANK repeats.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.13 RPKM in Bladder
Total median expression: 230.29 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -132.81312-0.426 Picture PostScript Text
3' UTR -250.74680-0.369 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom

Pfam Domains:
PF00023 - Ankyrin repeat
PF12796 - Ankyrin repeats (3 copies)
PF13606 - Ankyrin repeat
PF13637 - Ankyrin repeats (many copies)
PF13857 - Ankyrin repeats (many copies)

SCOP Domains:
48403 - Ankyrin repeat

ModBase Predicted Comparative 3D Structure on E5RJM6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Protein Sequence   

-  Descriptions from all associated GenBank mRNAs
  BC063445 - Homo sapiens cDNA clone IMAGE:5502103, partial cds.
BC018095 - Homo sapiens cDNA clone IMAGE:4793786.
BC073150 - Homo sapiens cDNA clone IMAGE:5763899, partial cds.
BC094869 - Homo sapiens cDNA clone IMAGE:5441587.
M32220 - Human DNA/endogenous retroviral long terminal repeat (LTR) junction mRNA, clone lambda-LTR22.
JD470897 - Sequence 451921 from Patent EP1572962.
JD492236 - Sequence 473260 from Patent EP1572962.
JD422486 - Sequence 403510 from Patent EP1572962.
JD509481 - Sequence 490505 from Patent EP1572962.
JD551221 - Sequence 532245 from Patent EP1572962.
JD524940 - Sequence 505964 from Patent EP1572962.
JD055720 - Sequence 36744 from Patent EP1572962.
JD210281 - Sequence 191305 from Patent EP1572962.
JD178503 - Sequence 159527 from Patent EP1572962.
JD200909 - Sequence 181933 from Patent EP1572962.
JD400647 - Sequence 381671 from Patent EP1572962.
JD537118 - Sequence 518142 from Patent EP1572962.
JD465329 - Sequence 446353 from Patent EP1572962.
JD057871 - Sequence 38895 from Patent EP1572962.
EU831775 - Synthetic construct Homo sapiens clone HAIB:100066804; DKFZo008C0721 hCG20426 protein (hCG_20426) gene, encodes complete protein.
EU831853 - Synthetic construct Homo sapiens clone HAIB:100066882; DKFZo004C0722 hCG20426 protein (hCG_20426) gene, encodes complete protein.
JD316971 - Sequence 297995 from Patent EP1572962.
JD411213 - Sequence 392237 from Patent EP1572962.
JD043910 - Sequence 24934 from Patent EP1572962.
JD186109 - Sequence 167133 from Patent EP1572962.
JD534025 - Sequence 515049 from Patent EP1572962.
JD515571 - Sequence 496595 from Patent EP1572962.
JD303533 - Sequence 284557 from Patent EP1572962.
JD312325 - Sequence 293349 from Patent EP1572962.
JD127497 - Sequence 108521 from Patent EP1572962.
JD192818 - Sequence 173842 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ANR65_HUMAN, E5RJM6, NM_001145210, NP_001138682
UCSC ID: uc010nyo.2
RefSeq Accession: NM_001145210
Protein: E5RJM6 (aka ANR65_HUMAN)
CCDS: CCDS55558.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001145210.2
exon count: 4CDS single in 3' UTR: no RNA size: 2205
ORF size: 1200CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2173.00frame shift in genome: no % Coverage: 99.41
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.