Human Gene CDK11A (uc010nyu.1) Description and Page Index
  Description: Homo sapiens cyclin-dependent kinase 11A (CDK11A), transcript variant 4, mRNA.
RefSeq Summary (NM_033529): This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Transcript (Including UTRs)
   Position: hg19 chr1:1,637,081-1,655,791 Size: 18,711 Total Exon Count: 11 Strand: -


Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionOther SpeciesmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:1,637,081-1,655,791)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerH-INVHGNCLynx
PubMedStanford SOURCETreefamWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CDK11A
CDC HuGE Published Literature: CDK11A

-  MalaCards Disease Associations
  MalaCards Gene Search: CDK11A
Diseases sorted by gene-association score: neuroblastoma (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 32.76 RPKM in Spleen
Total median expression: 785.55 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK000081 - Homo sapiens cDNA FLJ20074 fis, clone COL02336, highly similar to M37712 Human p58/GTA.
AF067524 - Homo sapiens PITSLRE protein kinase beta SV12 isoform (CDC2L2) mRNA, complete cds.
AF067512 - Homo sapiens PITSLRE protein kinase alpha SV1 isoform (CDC2L1) mRNA, complete cds.
AF067513 - Homo sapiens PITSLRE protein kinase alpha SV4 isoform (CDC2L1) mRNA, complete cds.
AF067514 - Homo sapiens PITSLRE protein kinase alpha SV5 isoform (CDC2L1) mRNA, complete cds.
AF067515 - Homo sapiens PITSLRE protein kinase alpha SV9 isoform (CDC2L1) mRNA, complete cds.
AF067516 - Homo sapiens PITSLRE protein kinase alpha SV10 isoform (CDC2L1) mRNA, complete cds.
AF067517 - Homo sapiens PITSLRE protein kinase alpha SV11 isoform (CDC2L1) mRNA, complete cds.
U04816 - Human protein kinase PITSLRE alpha 2-2 mRNA, complete cds.
U04817 - Human protein kinase PITSLRE alpha 2-3 mRNA, complete cds.
U04818 - Human protein kinase PITSLRE alpha 2-4 mRNA, complete cds.
U04824 - Human protein kinase PITSLRE alpha 2-1 mRNA, complete cds.
AK304679 - Homo sapiens cDNA FLJ59152 complete cds, highly similar to PITSLRE serine/threonine-protein kinaseCDC2L1 (EC 2.7.11.22).
BC140714 - Homo sapiens cell division cycle 2-like 1 (PITSLRE proteins), mRNA (cDNA clone MGC:176391 IMAGE:9021582), complete cds.
BC171773 - Homo sapiens cell division cycle 2-like 1 (PITSLRE proteins), mRNA (cDNA clone MGC:198488 IMAGE:9054427), complete cds.
U04819 - Human protein kinase PITSLRE beta 1 mRNA, complete cds.
BC073855 - Homo sapiens cDNA clone IMAGE:5196751, **** WARNING: chimeric clone ****.
BC094827 - Homo sapiens cell division cycle 2-like 2 (PITSLRE proteins), mRNA (cDNA clone IMAGE:6378299), partial cds.
BC110905 - Homo sapiens cell division cycle 2-like 2 (PITSLRE proteins), mRNA (cDNA clone MGC:131975 IMAGE:6151813), complete cds.
BC014464 - Homo sapiens cell division cycle 2-like 2 (PITSLRE proteins), mRNA (cDNA clone IMAGE:4899488), partial cds.
AB209095 - Homo sapiens mRNA for cell division cycle 2-like 2 isoform 4 variant protein.
AF067525 - Homo sapiens PITSLRE protein kinase beta SV13 isoform (CDC2L2) mRNA, complete cds.
AF067518 - Homo sapiens PITSLRE protein kinase beta SV8 isoform (CDC2L2) mRNA, complete cds.
AF067519 - Homo sapiens PITSLRE protein kinase beta SV1 isoform (CDC2L2) mRNA, complete cds.
AF067520 - Homo sapiens PITSLRE protein kinase beta SV2 isoform (CDC2L2) mRNA, complete cds.
AF067521 - Homo sapiens PITSLRE protein kinase beta SV3 isoform (CDC2L2) mRNA, complete cds.
AF067522 - Homo sapiens PITSLRE protein kinase beta SV6 isoform (CDC2L2) mRNA, complete cds.
AF067523 - Homo sapiens PITSLRE protein kinase beta SV7 isoform (CDC2L2) mRNA, complete cds.
U07704 - Human protein kinase PITSLRE isoform PBETA21 (p58CDC2L1) mRNA, complete cds.
U07705 - Human protein kinase PITSLRE isoform PBETA22 (p58CDC2L1) mRNA, complete cds.
KJ904348 - Synthetic construct Homo sapiens clone ccsbBroadEn_13742 CDK11A gene, encodes complete protein.
AK303451 - Homo sapiens cDNA FLJ56557 complete cds, highly similar to PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22).
AK303446 - Homo sapiens cDNA FLJ56415 complete cds, highly similar to PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22).
AK301495 - Homo sapiens cDNA FLJ55257 complete cds, moderately similar to PITSLRE serine/threonine-protein kinaseCDC2L2 (EC 2.7.11.22).
JD345120 - Sequence 326144 from Patent EP1572962.
JD292635 - Sequence 273659 from Patent EP1572962.
AX033421 - Sequence 2 from Patent WO0044896.
JD043805 - Sequence 24829 from Patent EP1572962.
JD468561 - Sequence 449585 from Patent EP1572962.
JD073738 - Sequence 54762 from Patent EP1572962.
JD445039 - Sequence 426063 from Patent EP1572962.
JD065460 - Sequence 46484 from Patent EP1572962.
JD043760 - Sequence 24784 from Patent EP1572962.
JD436361 - Sequence 417385 from Patent EP1572962.
JD468542 - Sequence 449566 from Patent EP1572962.
JD471391 - Sequence 452415 from Patent EP1572962.
JD468559 - Sequence 449583 from Patent EP1572962.
JD073737 - Sequence 54761 from Patent EP1572962.
JD471164 - Sequence 452188 from Patent EP1572962.
JD340003 - Sequence 321027 from Patent EP1572962.
JD178297 - Sequence 159321 from Patent EP1572962.
JD471387 - Sequence 452411 from Patent EP1572962.
AK295607 - Homo sapiens cDNA FLJ59025 complete cds, moderately similar to PITSLRE serine/threonine-protein kinaseCDC2L1 (EC 2.7.11.22).
JD248560 - Sequence 229584 from Patent EP1572962.
JD057707 - Sequence 38731 from Patent EP1572962.
BC028187 - Homo sapiens cell division cycle 2-like 2 (PITSLRE proteins), mRNA (cDNA clone IMAGE:4397976), partial cds.
BC009375 - Homo sapiens cell division cycle 2-like 1 (PITSLRE proteins), mRNA (cDNA clone IMAGE:4121554), partial cds.
JD094062 - Sequence 75086 from Patent EP1572962.
JD075744 - Sequence 56768 from Patent EP1572962.
JD518370 - Sequence 499394 from Patent EP1572962.
JD554198 - Sequence 535222 from Patent EP1572962.
JD274488 - Sequence 255512 from Patent EP1572962.
AF067527 - Homo sapiens PITSLRE protein kinase beta SV16 isoform (CDC2L2) mRNA, partial cds.
AF067529 - Homo sapiens PITSLRE protein kinase beta SV18 isoform (CDC2L2) mRNA, partial cds.
AF067526 - Homo sapiens PITSLRE protein kinase beta SV15 isoform (CDC2L2) mRNA, partial cds.
AF067528 - Homo sapiens PITSLRE protein kinase beta SV17 isoform (CDC2L2) mRNA, partial cds.
JD214789 - Sequence 195813 from Patent EP1572962.
JD214788 - Sequence 195812 from Patent EP1572962.
JD395312 - Sequence 376336 from Patent EP1572962.
JD395313 - Sequence 376337 from Patent EP1572962.
JD436764 - Sequence 417788 from Patent EP1572962.
JD090259 - Sequence 71283 from Patent EP1572962.
JD565542 - Sequence 546566 from Patent EP1572962.
JD396426 - Sequence 377450 from Patent EP1572962.
JD470936 - Sequence 451960 from Patent EP1572962.
JD039352 - Sequence 20376 from Patent EP1572962.
JD437278 - Sequence 418302 from Patent EP1572962.
JD433874 - Sequence 414898 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_HivnefPathway - HIV-I Nef: negative effector of Fas and TNF

-  Other Names for This Gene
  Alternate Gene Symbols: AK301495
UCSC ID: uc010nyu.1
RefSeq Accession: NM_033529

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: yes RNA accession: AK301495.1
exon count: 11CDS single in 3' UTR: no RNA size: 1255
ORF size: 0CDS single in intron: no Alignment % ID: 99.84
txCdsPredict score: 1198.00frame shift in genome: no % Coverage: 99.76
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.