Human Gene NFIA (uc010oos.2) Description and Page Index
Description: Homo sapiens nuclear factor I/A (NFIA), transcript variant 4, mRNA. RefSeq Summary (NM_001145512): This gene encodes a member of the NF1 (nuclear factor 1) family of transcription factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]. Transcript (Including UTRs) Position: hg19 chr1:61,547,534-61,928,460 Size: 380,927 Total Exon Count: 12 Strand: + Coding Region Position: hg19 chr1:61,547,616-61,920,992 Size: 373,377 Coding Exon Count: 12
ID:F8W8W3_HUMAN DESCRIPTION: RecName: Full=Nuclear factor 1; FUNCTION: Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication (By similarity). SUBUNIT: Binds DNA as a homodimer (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). SIMILARITY: Belongs to the CTF/NF-I family. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
Genetic Association Studies of Complex Diseases and Disorders
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00859 - CTF/NF-I family transcription modulation region PF03165 - MH1 domain PF10524 - Nuclear factor I protein pre-N-terminus
ModBase Predicted Comparative 3D Structure on F8W8W3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.