Human Gene PTPN7 (uc010ppy.2) Description and Page Index
  Description: Homo sapiens protein tyrosine phosphatase, non-receptor type 7 (PTPN7), transcript variant 1, mRNA.
RefSeq Summary (NM_002832): The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2010].
Transcript (Including UTRs)
   Position: hg19 chr1:202,117,341-202,130,716 Size: 13,376 Total Exon Count: 8 Strand: -


Page IndexSequence and LinksCTDRNA-Seq ExpressionMicroarray ExpressionOther Species
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:202,117,341-202,130,716)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneNetworkH-INVHGNC
LynxPubMedStanford SOURCETreefamWikipedia

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.40 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 99.50 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK127214 - Homo sapiens cDNA FLJ45281 fis, clone BRHIP3001481, highly similar to Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48).
D11327 - Homo sapiens LC-PTP mRNA for protein-tyrosine phosphatase, complete cds.
BC001746 - Homo sapiens protein tyrosine phosphatase, non-receptor type 7, mRNA (cDNA clone MGC:2258 IMAGE:3543111), complete cds.
M64322 - Human protein tyrosine phosphatase (LPTPase) mRNA, complete cds.
AK301980 - Homo sapiens cDNA FLJ55006 complete cds, highly similar to Tyrosine-protein phosphatase non-receptor type7 (EC 3.1.3.48).
AK301757 - Homo sapiens cDNA FLJ60931 complete cds, highly similar to Tyrosine-protein phosphatase non-receptor type7 (EC 3.1.3.48).
JD509143 - Sequence 490167 from Patent EP1572962.
JD432858 - Sequence 413882 from Patent EP1572962.
AK301051 - Homo sapiens cDNA FLJ52772 complete cds, highly similar to Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48).
AK225920 - Homo sapiens mRNA for protein tyrosine phosphatase, non-receptor type 7 isoform 2 variant, clone: FCC118C10.
JD381425 - Sequence 362449 from Patent EP1572962.
JD209248 - Sequence 190272 from Patent EP1572962.
AK293186 - Homo sapiens cDNA FLJ60410 complete cds, highly similar to Tyrosine-protein phosphatase non-receptor type7 (EC 3.1.3.48).
AK302869 - Homo sapiens cDNA FLJ55182 complete cds, highly similar to Tyrosine-protein phosphatase non-receptor type7 (EC 3.1.3.48).
JD387487 - Sequence 368511 from Patent EP1572962.
BT009848 - Homo sapiens protein tyrosine phosphatase, non-receptor type 7 mRNA, complete cds.
AB527607 - Synthetic construct DNA, clone: pF1KB0405, Homo sapiens PTPN7 gene for protein tyrosine phosphatase, non-receptor type 7, without stop codon, in Flexi system.
AF394064 - Homo sapiens dual specificity phosphatase 1 mRNA, complete cds.
S78090 - BPTP-4=protein-tyrosine phosphatase [human, pre-B cell NALM-6, mRNA, 264 nt].
AK311661 - Homo sapiens cDNA, FLJ18703.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04010 - MAPK signaling pathway

BioCarta from NCI Cancer Genome Anatomy Project
h_tcrPathway - T Cell Receptor Signaling Pathway

-  Other Names for This Gene
  Alternate Gene Symbols: AK301757
UCSC ID: uc010ppy.2
RefSeq Accession: NM_002832

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: no RNA accession: AK301757.1
exon count: 8CDS single in 3' UTR: no RNA size: 1148
ORF size: 0CDS single in intron: no Alignment % ID: 99.91
txCdsPredict score: 537.50frame shift in genome: no % Coverage: 99.91
has start codon: no stop codon in genome: no # of Alignments: 1
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.