Human Gene SH3PXD2A (uc010qqt.1) Description and Page Index
  Description: Homo sapiens SH3 and PX domains 2A (SH3PXD2A), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr10:105,353,784-105,452,934 Size: 99,151 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr10:105,361,573-105,452,843 Size: 91,271 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:105,353,784-105,452,934)mRNA (may differ from genome)Protein (982 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMGIPubMed
Stanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: B7Z9L8_HUMAN
DESCRIPTION: SubName: Full=cDNA, FLJ78882, highly similar to Homo sapiens SH3 multiple domains 1 (SH3MD1), mRNA;
SIMILARITY: Contains 5 SH3 domains.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): SH3PXD2A
CDC HuGE Published Literature: SH3PXD2A
Positive Disease Associations: Metabolism
Related Studies:
  1. Metabolism
    , , . [PubMed 0]

-  MalaCards Disease Associations
  MalaCards Gene Search: SH3PXD2A
Diseases sorted by gene-association score: malignant peripheral nerve sheath tumor* (247)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 40.28 RPKM in Nerve - Tibial
Total median expression: 716.16 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -33.9091-0.373 Picture PostScript Text
3' UTR -2868.677789-0.368 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011511 - SH3_2
IPR001452 - SH3_domain

Pfam Domains:
PF00018 - SH3 domain
PF07653 - Variant SH3 domain
PF14604 - Variant SH3 domain

SCOP Domains:
50044 - SH3-domain

ModBase Predicted Comparative 3D Structure on B7Z9L8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK295314 - Homo sapiens cDNA FLJ59690 complete cds, highly similar to Mus musculus SH3 and PX domains 2A (Sh3pxd2a), mRNA.
AB007878 - Homo sapiens KIAA0418 mRNA, partial cds.
AK302015 - Homo sapiens cDNA FLJ58079 complete cds, highly similar to Homo sapiens SH3 multiple domains 1 (SH3MD1), mRNA.
AK295660 - Homo sapiens cDNA FLJ56087 complete cds, highly similar to Homo sapiens SH3 multiple domains 1 (SH3MD1), mRNA.
AK294736 - Homo sapiens cDNA FLJ56896 complete cds, highly similar to Homo sapiens SH3 multiple domains 1 (SH3MD1), mRNA.
AK304828 - Homo sapiens cDNA FLJ57808 complete cds, highly similar to Homo sapiens SH3 multiple domains 1 (SH3MD1), mRNA.
AK315983 - Homo sapiens cDNA, FLJ78882 complete cds, highly similar to Homo sapiens SH3 multiple domains 1 (SH3MD1), mRNA.
AK056469 - Homo sapiens cDNA FLJ31907 fis, clone NT2RP7004396, highly similar to Homo sapiens SH3 multiple domains 1 (SH3MD1), mRNA.
AK294454 - Homo sapiens cDNA FLJ53508 complete cds, highly similar to Homo sapiens SH3 multiple domains 1 (SH3MD1), mRNA.
BC156572 - Synthetic construct Homo sapiens clone IMAGE:100062077, MGC:190164 SH3 and PX domains 2A (SH3PXD2A) mRNA, encodes complete protein.
BC146309 - Synthetic construct Homo sapiens clone IMAGE:100015244, MGC:180262 SH3 and PX domains 2A (SH3PXD2A) mRNA, encodes complete protein.
AB385330 - Synthetic construct DNA, clone: pF1KA0418, Homo sapiens SH3PXD2A gene for SH3 and PX domain-containing protein 2A, complete cds, without stop codon, in Flexi system.
MP202722 - Sequence 33 from Patent WO2019090263.
LF211366 - JP 2014500723-A/18869: Polycomb-Associated Non-Coding RNAs.
AK025783 - Homo sapiens cDNA: FLJ22130 fis, clone HEP19632.
BX647371 - Homo sapiens mRNA; cDNA DKFZp686B16111 (from clone DKFZp686B16111).
AK096575 - Homo sapiens cDNA FLJ39256 fis, clone OCBBF2008822.
AL833070 - Homo sapiens mRNA; cDNA DKFZp451A0419 (from clone DKFZp451A0419); complete cds.
AK123570 - Homo sapiens cDNA FLJ41576 fis, clone CTONG2019248.
DQ590336 - Homo sapiens piRNA piR-57448, complete sequence.
JD269058 - Sequence 250082 from Patent EP1572962.
JD066249 - Sequence 47273 from Patent EP1572962.
JD160171 - Sequence 141195 from Patent EP1572962.
JD524810 - Sequence 505834 from Patent EP1572962.
JD353885 - Sequence 334909 from Patent EP1572962.
JD268927 - Sequence 249951 from Patent EP1572962.
JD308625 - Sequence 289649 from Patent EP1572962.
JD538970 - Sequence 519994 from Patent EP1572962.
JD550893 - Sequence 531917 from Patent EP1572962.
JD233755 - Sequence 214779 from Patent EP1572962.
JD286395 - Sequence 267419 from Patent EP1572962.
JD306022 - Sequence 287046 from Patent EP1572962.
LF345922 - JP 2014500723-A/153425: Polycomb-Associated Non-Coding RNAs.
DQ596044 - Homo sapiens piRNA piR-34110, complete sequence.
JD086578 - Sequence 67602 from Patent EP1572962.
JD129370 - Sequence 110394 from Patent EP1572962.
JD172009 - Sequence 153033 from Patent EP1572962.
JD440912 - Sequence 421936 from Patent EP1572962.
JD330696 - Sequence 311720 from Patent EP1572962.
LF345923 - JP 2014500723-A/153426: Polycomb-Associated Non-Coding RNAs.
JD047799 - Sequence 28823 from Patent EP1572962.
JD070934 - Sequence 51958 from Patent EP1572962.
JD383890 - Sequence 364914 from Patent EP1572962.
JD536475 - Sequence 517499 from Patent EP1572962.
JD307222 - Sequence 288246 from Patent EP1572962.
JD438218 - Sequence 419242 from Patent EP1572962.
JD148464 - Sequence 129488 from Patent EP1572962.
JD228319 - Sequence 209343 from Patent EP1572962.
JD304832 - Sequence 285856 from Patent EP1572962.
JD503048 - Sequence 484072 from Patent EP1572962.
LF345924 - JP 2014500723-A/153427: Polycomb-Associated Non-Coding RNAs.
JD166992 - Sequence 148016 from Patent EP1572962.
DQ598621 - Homo sapiens piRNA piR-36687, complete sequence.
JD249122 - Sequence 230146 from Patent EP1572962.
JD237610 - Sequence 218634 from Patent EP1572962.
JD315520 - Sequence 296544 from Patent EP1572962.
JD085300 - Sequence 66324 from Patent EP1572962.
JD052319 - Sequence 33343 from Patent EP1572962.
JD363632 - Sequence 344656 from Patent EP1572962.
JD050635 - Sequence 31659 from Patent EP1572962.
JD097334 - Sequence 78358 from Patent EP1572962.
JD474560 - Sequence 455584 from Patent EP1572962.
JD275074 - Sequence 256098 from Patent EP1572962.
JD549134 - Sequence 530158 from Patent EP1572962.
JD526905 - Sequence 507929 from Patent EP1572962.
JD136771 - Sequence 117795 from Patent EP1572962.
JD358659 - Sequence 339683 from Patent EP1572962.
LF345925 - JP 2014500723-A/153428: Polycomb-Associated Non-Coding RNAs.
JD063351 - Sequence 44375 from Patent EP1572962.
JD387003 - Sequence 368027 from Patent EP1572962.
JD532375 - Sequence 513399 from Patent EP1572962.
JD080903 - Sequence 61927 from Patent EP1572962.
JD421176 - Sequence 402200 from Patent EP1572962.
JD535307 - Sequence 516331 from Patent EP1572962.
JD131936 - Sequence 112960 from Patent EP1572962.
JD221796 - Sequence 202820 from Patent EP1572962.
LF345926 - JP 2014500723-A/153429: Polycomb-Associated Non-Coding RNAs.
JD085468 - Sequence 66492 from Patent EP1572962.
JD487624 - Sequence 468648 from Patent EP1572962.
JD179169 - Sequence 160193 from Patent EP1572962.
JD538980 - Sequence 520004 from Patent EP1572962.
JD390294 - Sequence 371318 from Patent EP1572962.
LF345927 - JP 2014500723-A/153430: Polycomb-Associated Non-Coding RNAs.
DQ570869 - Homo sapiens piRNA piR-30981, complete sequence.
JD235717 - Sequence 216741 from Patent EP1572962.
JD401060 - Sequence 382084 from Patent EP1572962.
JD221180 - Sequence 202204 from Patent EP1572962.
JD485506 - Sequence 466530 from Patent EP1572962.
JD565749 - Sequence 546773 from Patent EP1572962.
JD191510 - Sequence 172534 from Patent EP1572962.
JD270815 - Sequence 251839 from Patent EP1572962.
JD352769 - Sequence 333793 from Patent EP1572962.
LF345928 - JP 2014500723-A/153431: Polycomb-Associated Non-Coding RNAs.
JD142038 - Sequence 123062 from Patent EP1572962.
JD060052 - Sequence 41076 from Patent EP1572962.
JD432863 - Sequence 413887 from Patent EP1572962.
JD444517 - Sequence 425541 from Patent EP1572962.
JD455556 - Sequence 436580 from Patent EP1572962.
JD036937 - Sequence 17961 from Patent EP1572962.
JD307887 - Sequence 288911 from Patent EP1572962.
JD482079 - Sequence 463103 from Patent EP1572962.
JD339339 - Sequence 320363 from Patent EP1572962.
LF345929 - JP 2014500723-A/153432: Polycomb-Associated Non-Coding RNAs.
JD332823 - Sequence 313847 from Patent EP1572962.
LF345930 - JP 2014500723-A/153433: Polycomb-Associated Non-Coding RNAs.
JD288567 - Sequence 269591 from Patent EP1572962.
JD464318 - Sequence 445342 from Patent EP1572962.
DQ583045 - Homo sapiens piRNA piR-50157, complete sequence.
JD289218 - Sequence 270242 from Patent EP1572962.
LF345931 - JP 2014500723-A/153434: Polycomb-Associated Non-Coding RNAs.
JD483827 - Sequence 464851 from Patent EP1572962.
JD287704 - Sequence 268728 from Patent EP1572962.
JD394301 - Sequence 375325 from Patent EP1572962.
JD123763 - Sequence 104787 from Patent EP1572962.
JD055529 - Sequence 36553 from Patent EP1572962.
JD291099 - Sequence 272123 from Patent EP1572962.
JD241737 - Sequence 222761 from Patent EP1572962.
JD542009 - Sequence 523033 from Patent EP1572962.
JD243655 - Sequence 224679 from Patent EP1572962.
JD486644 - Sequence 467668 from Patent EP1572962.
JD426655 - Sequence 407679 from Patent EP1572962.
JD109545 - Sequence 90569 from Patent EP1572962.
JD345239 - Sequence 326263 from Patent EP1572962.
JD465231 - Sequence 446255 from Patent EP1572962.
JD195477 - Sequence 176501 from Patent EP1572962.
JD546649 - Sequence 527673 from Patent EP1572962.
JD499388 - Sequence 480412 from Patent EP1572962.
JD118866 - Sequence 99890 from Patent EP1572962.
JD436795 - Sequence 417819 from Patent EP1572962.
JD062424 - Sequence 43448 from Patent EP1572962.
JD506971 - Sequence 487995 from Patent EP1572962.
JD286448 - Sequence 267472 from Patent EP1572962.
JD208459 - Sequence 189483 from Patent EP1572962.
JD466992 - Sequence 448016 from Patent EP1572962.
JD261828 - Sequence 242852 from Patent EP1572962.
JD564834 - Sequence 545858 from Patent EP1572962.
JD385515 - Sequence 366539 from Patent EP1572962.
JD214940 - Sequence 195964 from Patent EP1572962.
JD378060 - Sequence 359084 from Patent EP1572962.
JD052684 - Sequence 33708 from Patent EP1572962.
JD364101 - Sequence 345125 from Patent EP1572962.
JD204228 - Sequence 185252 from Patent EP1572962.
DQ593885 - Homo sapiens piRNA piR-33997, complete sequence.
JD320818 - Sequence 301842 from Patent EP1572962.
JD276965 - Sequence 257989 from Patent EP1572962.
JD493711 - Sequence 474735 from Patent EP1572962.
JD107335 - Sequence 88359 from Patent EP1572962.
JD456573 - Sequence 437597 from Patent EP1572962.
JD220223 - Sequence 201247 from Patent EP1572962.
JD356191 - Sequence 337215 from Patent EP1572962.
JD170669 - Sequence 151693 from Patent EP1572962.
JD449404 - Sequence 430428 from Patent EP1572962.
JD286467 - Sequence 267491 from Patent EP1572962.
JD357449 - Sequence 338473 from Patent EP1572962.
JD218892 - Sequence 199916 from Patent EP1572962.
JD485843 - Sequence 466867 from Patent EP1572962.
JD088237 - Sequence 69261 from Patent EP1572962.
DQ580691 - Homo sapiens piRNA piR-48803, complete sequence.
JD476101 - Sequence 457125 from Patent EP1572962.
DQ586987 - Homo sapiens piRNA piR-54099, complete sequence.
DQ574090 - Homo sapiens piRNA piR-42202, complete sequence.
DQ584132 - Homo sapiens piRNA piR-51244, complete sequence.
MA581499 - JP 2018138019-A/153425: Polycomb-Associated Non-Coding RNAs.
MA581500 - JP 2018138019-A/153426: Polycomb-Associated Non-Coding RNAs.
MA581501 - JP 2018138019-A/153427: Polycomb-Associated Non-Coding RNAs.
MA581502 - JP 2018138019-A/153428: Polycomb-Associated Non-Coding RNAs.
MA581503 - JP 2018138019-A/153429: Polycomb-Associated Non-Coding RNAs.
MA581504 - JP 2018138019-A/153430: Polycomb-Associated Non-Coding RNAs.
MA581505 - JP 2018138019-A/153431: Polycomb-Associated Non-Coding RNAs.
MA581506 - JP 2018138019-A/153432: Polycomb-Associated Non-Coding RNAs.
MA581507 - JP 2018138019-A/153433: Polycomb-Associated Non-Coding RNAs.
MA581508 - JP 2018138019-A/153434: Polycomb-Associated Non-Coding RNAs.
MA446943 - JP 2018138019-A/18869: Polycomb-Associated Non-Coding RNAs.
JD437351 - Sequence 418375 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK315983, B7Z9L8, B7Z9L8_HUMAN, NM_014631, NP_055446
UCSC ID: uc010qqt.1
RefSeq Accession: NM_014631
Protein: B7Z9L8

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK315983.1
exon count: 9CDS single in 3' UTR: no RNA size: 3123
ORF size: 2949CDS single in intron: no Alignment % ID: 99.90
txCdsPredict score: 5038.50frame shift in genome: no % Coverage: 99.97
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 120# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.