Human Gene TACC2 (uc010qtv.2) Description and Page Index
  Description: Homo sapiens transforming, acidic coiled-coil containing protein 2 (TACC2), transcript variant 1, mRNA.
RefSeq Summary (NM_206862): Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr10:123,748,689-124,014,057 Size: 265,369 Total Exon Count: 20 Strand: +
Coding Region
   Position: hg19 chr10:123,781,497-124,013,571 Size: 232,075 Coding Exon Count: 19 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr10:123,748,689-124,014,057)mRNA (may differ from genome)Protein (2875 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
PubMedStanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=Transforming acidic coiled-coil-containing protein 2;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TACC2
CDC HuGE Published Literature: TACC2
Positive Disease Associations: Tunica Media
Related Studies:
  1. Tunica Media
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 44.34 RPKM in Muscle - Skeletal
Total median expression: 408.32 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -104.80360-0.291 Picture PostScript Text
3' UTR -115.60486-0.238 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007707 - TACC

Pfam Domains:
PF05010 - Transforming acidic coiled-coil-containing protein (TACC)

ModBase Predicted Comparative 3D Structure on E9PBC6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane

-  Descriptions from all associated GenBank mRNAs
  AF528098 - Homo sapiens transforming acidic coiled coil 2, short isoform (TACC2) mRNA, complete cds.
AF528099 - Homo sapiens transforming acidic coiled coil 2, long isoform (TACC2) mRNA, complete cds.
BC144599 - Homo sapiens transforming, acidic coiled-coil containing protein 2, mRNA (cDNA clone MGC:178146 IMAGE:9053129), complete cds.
BC144600 - Homo sapiens transforming, acidic coiled-coil containing protein 2, mRNA (cDNA clone MGC:178147 IMAGE:9053130), complete cds.
BC150627 - Homo sapiens transforming, acidic coiled-coil containing protein 2, mRNA (cDNA clone MGC:183537 IMAGE:9056997), complete cds.
AL833304 - Homo sapiens mRNA; cDNA DKFZp451N249 (from clone DKFZp451N249).
BC015736 - Homo sapiens transforming, acidic coiled-coil containing protein 2, mRNA (cDNA clone IMAGE:4865697), with apparent retained intron.
AF176646 - Homo sapiens anti zuai-1 mRNA, complete cds.
BC039311 - Homo sapiens transforming, acidic coiled-coil containing protein 2, mRNA (cDNA clone IMAGE:5295870), complete cds.
BC141837 - Homo sapiens cDNA clone IMAGE:40148972.
BC142673 - Homo sapiens cDNA clone IMAGE:40148198.
AF095791 - Homo sapiens TACC2 protein (TACC2) mRNA, complete cds.
AF220152 - Homo sapiens TACC2 mRNA, complete cds.
AL713712 - Homo sapiens mRNA; cDNA DKFZp564B0278 (from clone DKFZp564B0278).
AK027066 - Homo sapiens cDNA: FLJ23413 fis, clone HEP20672, highly similar to AF220152 Homo sapiens TACC2 mRNA.
AK075097 - Homo sapiens cDNA FLJ90616 fis, clone PLACE1002153, highly similar to Homo sapiens TACC2 protein (TACC2) mRNA.
BC010219 - Homo sapiens transforming, acidic coiled-coil containing protein 2, mRNA (cDNA clone IMAGE:3450479), with apparent retained intron.
BC031036 - Homo sapiens transforming, acidic coiled-coil containing protein 2, mRNA (cDNA clone IMAGE:4769062), with apparent retained intron.
AK094848 - Homo sapiens cDNA FLJ37529 fis, clone BRCAN2012613.
AK295631 - Homo sapiens cDNA FLJ54685 complete cds, highly similar to Transforming acidic coiled-coil-containing protein 2.
BC000999 - Homo sapiens, Similar to transforming, acidic coiled-coil containing protein 2, clone IMAGE:2984928, mRNA, partial cds.
AK095371 - Homo sapiens cDNA FLJ38052 fis, clone CTONG2014491, highly similar to Homo sapiens anti zuai-1 mRNA.
AK056743 - Homo sapiens cDNA FLJ32181 fis, clone PLACE6001740, moderately similar to Homo sapiens anti zuai-1 mRNA.
JD141952 - Sequence 122976 from Patent EP1572962.
JD109511 - Sequence 90535 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: BC144599, E9PBC6, E9PBC6_HUMAN, NM_206862, NP_996744
UCSC ID: uc010qtv.2
RefSeq Accession: NM_206862
Protein: E9PBC6 CCDS: CCDS7626.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: BC144599.1
exon count: 20CDS single in 3' UTR: no RNA size: 9245
ORF size: 8628CDS single in intron: no Alignment % ID: 99.88
txCdsPredict score: 14382.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.