Human Gene MICAL2 (uc010rcj.2) Description and Page Index
  Description: Homo sapiens microtubule associated monooxygenase, calponin and LIM domain containing 2 (MICAL2), mRNA.
RefSeq Summary (NM_014632): The protein encoded by this gene is a monooxygenase that enhances depolymerization of F-actin and is therefore involved in cytoskeletal dynamics. The encoded protein is a regulator of the SRF signaling pathway. Increased expression of this gene has been associated with cancer progression and metastasis. [provided by RefSeq, Oct 2016].
Transcript (Including UTRs)
   Position: hg19 chr11:12,244,164-12,285,331 Size: 41,168 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg19 chr11:12,247,824-12,281,719 Size: 33,896 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:12,244,164-12,285,331)mRNA (may differ from genome)Protein (414 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=cDNA FLJ58307, moderately similar to Protein MICAL-2;
SIMILARITY: Contains 1 LIM zinc-binding domain.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): MICAL2
CDC HuGE Published Literature: MICAL2
Positive Disease Associations: Asthma , Erythrocytes , Myocardial Infarction , Stroke , Waist Circumference
Related Studies:
  1. Asthma
    , , . [PubMed 0]
  2. Erythrocytes
    , , . [PubMed 0]
  3. Myocardial Infarction
    , , . [PubMed 0]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D013749 Tetrachlorodibenzodioxin
  • D000082 Acetaminophen
  • D016604 Aflatoxin B1
  • D001564 Benzo(a)pyrene
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C014211 2,3,7,8-tetrachlorodibenzofuran
  • C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
  • C547126 AZM551248
  • D000393 Air Pollutants
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 107.67 RPKM in Brain - Cerebellum
Total median expression: 541.49 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -154.40472-0.327 Picture PostScript Text
3' UTR -1245.953612-0.345 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001715 - CH-domain
IPR001781 - Znf_LIM

Pfam Domains:
PF00412 - LIM domain

SCOP Domains:
57716 - Glucocorticoid receptor-like (DNA-binding domain)

ModBase Predicted Comparative 3D Structure on B4DYS3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003779 actin binding
GO:0043914 NADPH:sulfur oxidoreductase activity
GO:0046872 metal ion binding

Biological Process:
GO:0010735 positive regulation of transcription via serum response element binding
GO:0030042 actin filament depolymerization
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  AK302893 - Homo sapiens cDNA FLJ58714 complete cds, highly similar to Protein MICAL-2.
AK302580 - Homo sapiens cDNA FLJ58307 complete cds, moderately similar to Protein MICAL-2.
BC044577 - Homo sapiens microtubule associated monoxygenase, calponin and LIM domain containing 2, mRNA (cDNA clone MGC:57164 IMAGE:5275364), complete cds.
AB018293 - Homo sapiens KIAA0750 mRNA for KIAA0750 protein.
AK294845 - Homo sapiens cDNA FLJ61246 complete cds, highly similar to Protein MICAL-2.
AB385380 - Synthetic construct DNA, clone: pF1KA0750, Homo sapiens MICAL2 gene for microtubule-associated monoxygenase, calponin and LIM domain-containing protein 2, complete cds, without stop codon, in Flexi system.
KJ898062 - Synthetic construct Homo sapiens clone ccsbBroadEn_07456 MICAL2 gene, encodes complete protein.
AB110785 - Homo sapiens MICAL2PV1 mRNA for flavoprotein oxidoreductase, complete cds.
AB110786 - Homo sapiens MICAL2PV2 mRNA for flavoprotein oxidoreductase, complete cds.
BX538021 - Homo sapiens mRNA; cDNA DKFZp686H2469 (from clone DKFZp686H2469); complete cds.
BX641163 - Homo sapiens mRNA; cDNA DKFZp686H03148 (from clone DKFZp686H03148).
AF052170 - Homo sapiens clone 24589 mRNA sequence.
AK122821 - Homo sapiens cDNA FLJ16424 fis, clone BRACE3005127.
AK127301 - Homo sapiens cDNA FLJ45368 fis, clone BRHIP3017256.
AK125785 - Homo sapiens cDNA FLJ43797 fis, clone TESTI4000215.
AK090550 - Homo sapiens cDNA FLJ33231 fis, clone ASTRO2001806.
AK125552 - Homo sapiens cDNA FLJ43564 fis, clone PUAEN2006723.
AK026116 - Homo sapiens cDNA: FLJ22463 fis, clone HRC10126.
AK025186 - Homo sapiens cDNA: FLJ21533 fis, clone COL06072.
BC017104 - Homo sapiens cDNA clone IMAGE:3505978.
BC048206 - Homo sapiens microtubule associated monoxygenase, calponin and LIM domain containing 2, mRNA (cDNA clone IMAGE:4842596).
BC063589 - Homo sapiens cDNA clone IMAGE:4442192, partial cds.
JD097931 - Sequence 78955 from Patent EP1572962.
JD081318 - Sequence 62342 from Patent EP1572962.
JD271027 - Sequence 252051 from Patent EP1572962.
JD085329 - Sequence 66353 from Patent EP1572962.
JD269362 - Sequence 250386 from Patent EP1572962.
JD245461 - Sequence 226485 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK302580, B4DYS3, B4DYS3_HUMAN
UCSC ID: uc010rcj.2
RefSeq Accession: NM_014632
Protein: B4DYS3

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: AK302580.1
exon count: 12CDS single in 3' UTR: no RNA size: 1822
ORF size: 1245CDS single in intron: no Alignment % ID: 99.95
txCdsPredict score: 2597.00frame shift in genome: no % Coverage: 90.45
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 3887# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.