Human Gene ALG5 (uc010teq.2) Description and Page Index
  Description: Homo sapiens ALG5, dolichyl-phosphate beta-glucosyltransferase (ALG5), transcript variant 2, mRNA.
RefSeq Summary (NM_001142364): This gene encodes a member of the glycosyltransferase 2 family. The encoded protein participates in glucosylation of the oligomannose core in N-linked glycosylation of proteins. The addition of glucose residues to the oligomannose core is necessary to ensure substrate recognition, and therefore, effectual transfer of the oligomannose core to the nascent glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008].
Transcript (Including UTRs)
   Position: hg19 chr13:37,523,908-37,573,504 Size: 49,597 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr13:37,524,079-37,573,437 Size: 49,359 Coding Exon Count: 9 

Page IndexSequence and LinksCTDGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:37,523,908-37,573,504)mRNA (may differ from genome)Protein (294 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMGIOMIM
PubMedReactomeStanford SOURCEUniProtKB

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 19.92 RPKM in Pancreas
Total median expression: 461.12 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -30.8067-0.460 Picture PostScript Text
3' UTR -24.42171-0.143 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00535 - Glycosyl transferase family 2

SCOP Domains:
53448 - Nucleotide-diphospho-sugar transferases

ModBase Predicted Comparative 3D Structure on Q9Y673-2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  KJ898734 - Synthetic construct Homo sapiens clone ccsbBroadEn_08128 ALG5 gene, encodes complete protein.
AF102850 - Homo sapiens dolichyl-phosphate beta-glucosyltransferase (ALG5) mRNA, complete cds.
AF161498 - Homo sapiens HSPC149 mRNA, complete cds.
AF183413 - Homo sapiens dolichyl-phosphate beta-glucosyltransferase mRNA, complete cds.
AK299085 - Homo sapiens cDNA FLJ54134 complete cds, highly similar to Dolichyl-phosphate beta-glucosyltransferase (EC 2.4.1.117).
AF088028 - Homo sapiens full length insert cDNA clone ZC19E11.
BC012531 - Homo sapiens asparagine-linked glycosylation 5, dolichyl-phosphate beta-glucosyltransferase homolog (S. cerevisiae), mRNA (cDNA clone MGC:13316 IMAGE:4273297), complete cds.
CU680348 - Synthetic construct Homo sapiens gateway clone IMAGE:100018105 5' read ALG5 mRNA.
HM245395 - Homo sapiens PIGU-ALG5 breakpoint junction mRNA sequence.
AK299126 - Homo sapiens cDNA FLJ56758 complete cds, highly similar to Dolichyl-phosphate beta-glucosyltransferase (EC 2.4.1.117).
AK097252 - Homo sapiens cDNA FLJ39933 fis, clone SPLEN2021440.
JD026078 - Sequence 7102 from Patent EP1572962.
JD029037 - Sequence 10061 from Patent EP1572962.
JD032932 - Sequence 13956 from Patent EP1572962.
JD019663 - Sequence 687 from Patent EP1572962.
JD022298 - Sequence 3322 from Patent EP1572962.
JD029284 - Sequence 10308 from Patent EP1572962.
DQ590097 - Homo sapiens piRNA piR-57209, complete sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00510 - N-Glycan biosynthesis
hsa01100 - Metabolic pathways

Reactome (by CSHL, EBI, and GO)

Protein Q9Y673 (Reactome details) participates in the following event(s):

R-HSA-446214 Synthesis of dolichyl-phosphate-glucose
R-HSA-480985 Synthesis of dolichyl-phosphate-glucose
R-HSA-446219 Synthesis of substrates in N-glycan biosythesis
R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
R-HSA-446203 Asparagine N-linked glycosylation
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: HSPC149, NM_001142364, NP_001135836, Q9Y673-2
UCSC ID: uc010teq.2
RefSeq Accession: NM_001142364
Protein: Q9Y673-2, splice isoform of Q9Y673 CCDS: CCDS45033.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001142364.1
exon count: 9CDS single in 3' UTR: no RNA size: 1137
ORF size: 885CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1963.00frame shift in genome: no % Coverage: 98.77
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.