Human Gene CRIP2 (uc010tyr.2) Description and Page Index
  Description: Homo sapiens cysteine-rich protein 2 (CRIP2), transcript variant 2, mRNA.
RefSeq Summary (NM_001270837): This gene encodes a putative transcription factor with two LIM zinc-binding domains. The encoded protein may participate in the differentiation of smooth muscle tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
Transcript (Including UTRs)
   Position: hg19 chr14:105,939,275-105,946,507 Size: 7,233 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr14:105,939,585-105,945,990 Size: 6,406 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:105,939,275-105,946,507)mRNA (may differ from genome)Protein (282 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCLynxMGIOMIMPubMed
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: B7Z6C0_HUMAN
DESCRIPTION: SubName: Full=Cysteine-rich protein 2; SubName: Full=cDNA FLJ56946, highly similar to Cysteine-rich protein 2;
SIMILARITY: Contains 2 LIM zinc-binding domains.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 170.17 RPKM in Heart - Atrial Appendage
Total median expression: 1998.80 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -137.70294-0.468 Picture PostScript Text
3' UTR -202.47517-0.392 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001781 - Znf_LIM

Pfam Domains:
PF00412 - LIM domain

SCOP Domains:
57716 - Glucocorticoid receptor-like (DNA-binding domain)

ModBase Predicted Comparative 3D Structure on B7Z6C0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  AK300092 - Homo sapiens cDNA FLJ56946 complete cds, highly similar to Cysteine-rich protein 2.
AK057837 - Homo sapiens cDNA FLJ25108 fis, clone CBR01507.
BC034151 - Homo sapiens cysteine-rich protein 2, mRNA (cDNA clone MGC:32803 IMAGE:4690443), complete cds.
AK315757 - Homo sapiens cDNA, FLJ96869, Homo sapiens cysteine-rich protein 2 (CRIP2), mRNA.
U36190 - Human cysteine-rich protein 2 (hCRP2) mRNA, complete cds.
BC128101 - Homo sapiens cysteine-rich protein 2, mRNA (cDNA clone MGC:149180 IMAGE:40109449), complete cds.
BC034386 - Homo sapiens cysteine-rich protein 2, mRNA (cDNA clone IMAGE:5198339), with apparent retained intron.
D42123 - Homo sapiens mRNA for cystein-rich protein 2, complete cds.
BC000434 - Homo sapiens cysteine-rich protein 2, mRNA (cDNA clone MGC:8366 IMAGE:2819982), complete cds.
BC001931 - Homo sapiens cysteine-rich protein 2, mRNA (cDNA clone MGC:3996 IMAGE:2819982), complete cds.
DQ894559 - Synthetic construct Homo sapiens clone IMAGE:100009019; FLH176392.01L; RZPDo839C10121D cysteine-rich protein 2 (CRIP2) gene, encodes complete protein.
DQ891382 - Synthetic construct clone IMAGE:100004012; FLH176396.01X; RZPDo839C10122D cysteine-rich protein 2 (CRIP2) gene, encodes complete protein.
AB528485 - Synthetic construct DNA, clone: pF1KB6939, Homo sapiens CRIP2 gene for cysteine-rich protein 2, without stop codon, in Flexi system.
KJ890970 - Synthetic construct Homo sapiens clone ccsbBroadEn_00364 CRIP2 gene, encodes complete protein.
BT019911 - Homo sapiens cysteine-rich protein 2 mRNA, complete cds.
AK223251 - Homo sapiens mRNA for cysteine-rich protein 2 variant, clone: STM06668.
AK091845 - Homo sapiens cDNA FLJ34526 fis, clone HLUNG2007433.
AX747217 - Sequence 742 from Patent EP1308459.
AK311402 - Homo sapiens cDNA, FLJ18444.
JD026057 - Sequence 7081 from Patent EP1572962.
JD034102 - Sequence 15126 from Patent EP1572962.
JD231045 - Sequence 212069 from Patent EP1572962.
JD474642 - Sequence 455666 from Patent EP1572962.
JD283801 - Sequence 264825 from Patent EP1572962.
JD390228 - Sequence 371252 from Patent EP1572962.
JD140984 - Sequence 122008 from Patent EP1572962.
JD161348 - Sequence 142372 from Patent EP1572962.
JD555017 - Sequence 536041 from Patent EP1572962.
JD482175 - Sequence 463199 from Patent EP1572962.
JD447918 - Sequence 428942 from Patent EP1572962.
JD197977 - Sequence 179001 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK300092, B7Z6C0, B7Z6C0_HUMAN, E9PD13, NM_001270837, NP_001257766, uc010tyr.1
UCSC ID: uc010tyr.2
RefSeq Accession: NM_001270837
Protein: B7Z6C0 CCDS: CCDS59246.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK300092.1
exon count: 9CDS single in 3' UTR: no RNA size: 1116
ORF size: 849CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1290.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.