Human Gene LIPC (uc010ugy.2) Description and Page Index
Description: Homo sapiens lipase, hepatic (LIPC), mRNA. RefSeq Summary (NM_000236): LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X07228.1, D83548.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000299022.10/ ENSP00000299022.5 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg19 chr15:58,724,192-58,861,073 Size: 136,882 Total Exon Count: 8 Strand: + Coding Region Position: hg19 chr15:58,724,232-58,861,026 Size: 136,795 Coding Exon Count: 8
ID:E7EUK6_HUMAN DESCRIPTION: SubName: Full=Hepatic triacylglycerol lipase; SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
Genetic Association Studies of Complex Diseases and Disorders
Amyotrophic lateral sclerosis van Es ,et al. 2007, Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis, .
Amyotrophic Lateral Sclerosis Michael A van Es et al. Nature genetics 2008, Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis., Nature genetics.
atherosclerosis, coronary Baroni, M. G. et al. 2003, Genetic study of common variants at the Apo E, Apo AI, Apo CIII, Apo B, lipoprotein lipase (LPL) and hepatic lipase (LIPC) genes and coronary artery disease (CAD): variation in LIPC gene associateswith clinical outcomes in patients with established CAD., BMC medical genetics [electronic resource]. 2003 Sep;4:8.
variation in LIPC (hepatic lipase) gene associates with clinical outcomes in Italian patients with established CAD. Further studies on the LIPC gene in CAD patients are warranted, in particular looking at the possible influences on clinical outcomes.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on E7EUK6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.