Human Gene PRSS8 (uc010vfe.2) Description and Page Index
  Description: Homo sapiens protease, serine, 8 (PRSS8), mRNA.
RefSeq Summary (NM_002773): This gene encodes a member of the peptidase S1 or chymotrypsin family of serine proteases. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate via a disulfide bond to form the heterodimeric enzyme. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. This protease exhibits trypsin-like substrate specificity, cleaving protein substrates at the carboxyl terminus of lysine or arginine residues. The encoded protease partially mediates proteolytic activation of the epithelial sodium channel, a regulator of sodium balance, and may also play a role in epithelial barrier formation. [provided by RefSeq, Feb 2016]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.525605.1, ERR279853.1190.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000317508.11/ ENSP00000319730.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr16:31,142,754-31,147,151 Size: 4,398 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr16:31,143,330-31,146,819 Size: 3,490 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr16:31,142,754-31,147,151)mRNA (may differ from genome)Protein (289 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
PubMedStanford SOURCETreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=Prostasin; SubName: Full=cDNA FLJ54275, highly similar to Prostasin (EC 3.4.21.-);
SIMILARITY: Belongs to the peptidase S1 family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): PRSS8
CDC HuGE Published Literature: PRSS8

-  MalaCards Disease Associations
  MalaCards Gene Search: PRSS8
Diseases sorted by gene-association score: ichthyosis, follicular (12), chromophobe renal cell carcinoma (6), conn's syndrome (6), cystic fibrosis (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 127.73 RPKM in Colon - Transverse
Total median expression: 1011.54 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -152.91332-0.461 Picture PostScript Text
3' UTR -235.72576-0.409 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009003 - Pept_cys/ser_Trypsin-like
IPR018114 - Peptidase_S1/S6_AS
IPR001254 - Peptidase_S1_S6
IPR001314 - Peptidase_S1A

Pfam Domains:
PF00089 - Trypsin

SCOP Domains:
50494 - Trypsin-like serine proteases

ModBase Predicted Comparative 3D Structure on B4DWP2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Descriptions from all associated GenBank mRNAs
  BC001462 - Homo sapiens protease, serine, 8, mRNA (cDNA clone MGC:2133 IMAGE:3138532), complete cds.
L41351 - Homo sapiens prostasin mRNA, complete cds.
JD447431 - Sequence 428455 from Patent EP1572962.
JD274093 - Sequence 255117 from Patent EP1572962.
JD389728 - Sequence 370752 from Patent EP1572962.
JD191043 - Sequence 172067 from Patent EP1572962.
JD129807 - Sequence 110831 from Patent EP1572962.
JD431598 - Sequence 412622 from Patent EP1572962.
JD189585 - Sequence 170609 from Patent EP1572962.
JD426195 - Sequence 407219 from Patent EP1572962.
JD484563 - Sequence 465587 from Patent EP1572962.
JD525632 - Sequence 506656 from Patent EP1572962.
JD052477 - Sequence 33501 from Patent EP1572962.
AK296656 - Homo sapiens cDNA FLJ53017 complete cds, moderately similar to Prostasin precursor (EC 3.4.21.-).
JD476016 - Sequence 457040 from Patent EP1572962.
JD215054 - Sequence 196078 from Patent EP1572962.
JD433594 - Sequence 414618 from Patent EP1572962.
JD402110 - Sequence 383134 from Patent EP1572962.
JD175059 - Sequence 156083 from Patent EP1572962.
AK301619 - Homo sapiens cDNA FLJ54275 complete cds, highly similar to Prostasin precursor (EC 3.4.21.-).
JD076729 - Sequence 57753 from Patent EP1572962.
DQ892160 - Synthetic construct clone IMAGE:100004790; FLH183572.01X; RZPDo839E02142D protease, serine, 8 (prostasin) (PRSS8) gene, encodes complete protein.
DQ895354 - Synthetic construct Homo sapiens clone IMAGE:100009814; FLH183568.01L; RZPDo839E02141D protease, serine, 8 (prostasin) (PRSS8) gene, encodes complete protein.
AK309955 - Homo sapiens cDNA, FLJ99996.
JD484709 - Sequence 465733 from Patent EP1572962.
JD429394 - Sequence 410418 from Patent EP1572962.
JD416472 - Sequence 397496 from Patent EP1572962.
JD484624 - Sequence 465648 from Patent EP1572962.
JD195823 - Sequence 176847 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK301619, B4DWP2, B4DWP2_HUMAN, NM_002773, NP_002764
UCSC ID: uc010vfe.2
RefSeq Accession: NM_002773
Protein: B4DWP2

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: AK301619.1
exon count: 6CDS single in 3' UTR: no RNA size: 1214
ORF size: 870CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1940.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.