Human Gene ZNF521 (uc010xbe.1) Description and Page Index
  Description: Homo sapiens zinc finger protein 521 (ZNF521), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr18:22,641,888-22,932,214 Size: 290,327 Total Exon Count: 9 Strand: -


Page IndexSequence and LinksGenetic AssociationsCTDRNA-Seq ExpressionMicroarray Expression
Other SpeciesmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr18:22,641,888-22,932,214)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblExonPrimerGeneNetworkH-INV
HGNCLynxPubMedStanford SOURCETreefamWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ZNF521
CDC HuGE Published Literature: ZNF521
Positive Disease Associations: Anticonvulsants , Body Weight , Hip , Waist-Hip Ratio
Related Studies:
  1. Anticonvulsants
    Mark McCormack et al. Pharmacogenomics 2012, Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions., Pharmacogenomics. [PubMed 22379998]
    HLA-A*3101 does not appear to be a predictor for lamotrigine- and phenytoin-induced cADRs in Europeans. Our genome-wide association study results do not support the existence of a clinically relevant common variant for the development of lamotrigine- or phenytoin-induced cADRs. As a predictive marker, HLA-A*3101 appears to be specific for carbamazepine-induced cADRs.
  2. Body Weight
    Asa Johansson et al. Obesity (Silver Spring, Md.) 2010, Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene., Obesity (Silver Spring, Md.). [PubMed 19851299]
  3. Hip
    Douglas P Kiel et al. BMC medical genetics 2007, Genome-wide association with bone mass and geometry in the Framingham Heart Study., BMC medical genetics. [PubMed 17903296]
    The FHS 100K SNP project offers an unbiased genome-wide strategy to identify new candidate loci and to replicate previously suggested candidate genes for osteoporosis.
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 41.83 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 233.25 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AF141339 - Homo sapiens LYST-interacting protein LIP3 mRNA, partial cds.
AK074046 - Homo sapiens mRNA for FLJ00107 protein.
AK027354 - Homo sapiens cDNA FLJ14448 fis, clone HEMBB1001482, weakly similar to ZINC FINGER PROTEIN 91.
AJ518106 - Homo sapiens mRNA for early hematopoietic zinc finger (EHZF gene).
AK021452 - Homo sapiens cDNA FLJ11390 fis, clone HEMBA1000561, weakly similar to ZINC FINGER PROTEIN 91.
AL117615 - Homo sapiens mRNA; cDNA DKFZp564D0764 (from clone DKFZp564D0764); partial cds.
BC032869 - Homo sapiens zinc finger protein 521, mRNA (cDNA clone IMAGE:5262637), partial cds.
BC113622 - Homo sapiens zinc finger protein 521, mRNA (cDNA clone MGC:142182 IMAGE:8322674), complete cds.
BC113648 - Homo sapiens zinc finger protein 521, mRNA (cDNA clone MGC:142208 IMAGE:8322700), complete cds.
BC143727 - Homo sapiens cDNA clone IMAGE:9052241.
DQ845345 - Homo sapiens PAX5/ZNF521 fusion protein (PAX5/ZNF521 fusion) mRNA, complete cds.
AK293067 - Homo sapiens cDNA FLJ77901 complete cds, highly similar to Homo sapiens zinc finger protein 521 (ZNF521), mRNA.
AB385259 - Synthetic construct DNA, clone: pF1KF0107, Homo sapiens ZNF521 gene for zinc finger protein 521, complete cds, without stop codon, in Flexi system.
JD419271 - Sequence 400295 from Patent EP1572962.
JD549921 - Sequence 530945 from Patent EP1572962.
JD090860 - Sequence 71884 from Patent EP1572962.
JD552675 - Sequence 533699 from Patent EP1572962.
JD293916 - Sequence 274940 from Patent EP1572962.
JD287584 - Sequence 268608 from Patent EP1572962.
DQ578349 - Homo sapiens piRNA piR-46461, complete sequence.
JD336433 - Sequence 317457 from Patent EP1572962.
JD419749 - Sequence 400773 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: BC143727
UCSC ID: uc010xbe.1
RefSeq Accession: NM_015461

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: yes RNA accession: BC143727.1
exon count: 9CDS single in 3' UTR: no RNA size: 4345
ORF size: 0CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 7083.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.