Human Gene PPP1R21 (uc010yok.2) Description and Page Index
  Description: Homo sapiens protein phosphatase 1, regulatory subunit 21 (PPP1R21), transcript variant 5, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr2:48,667,908-48,742,531 Size: 74,624 Total Exon Count: 20 Strand: +
Coding Region
   Position: hg19 chr2:48,668,093-48,741,883 Size: 73,791 Coding Exon Count: 20 

Page IndexSequence and LinksCTDGene AllelesRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesModel Information
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr2:48,667,908-48,742,531)mRNA (may differ from genome)Protein (738 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
Stanford SOURCETreefamUniProtKB

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.79 RPKM in Thyroid
Total median expression: 445.58 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -107.20185-0.579 Picture PostScript Text
3' UTR -158.60648-0.245 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF10205 - Predicted coiled-coil domain-containing protein
PF10212 - Predicted coiled-coil domain-containing protein

ModBase Predicted Comparative 3D Structure on Q6ZMI0-5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details  Gene DetailsGene Details 
Gene Sorter  Gene SorterGene Sorter 
  Protein SequenceProtein SequenceProtein Sequence 

-  Descriptions from all associated GenBank mRNAs
  AY134855 - Homo sapiens smooth muscle myosin heavy chain 11 isoform SM1-like protein mRNA, complete cds.
AK172762 - Homo sapiens cDNA FLJ23923 fis, clone COL03279.
AK122900 - Homo sapiens cDNA FLJ16566 fis, clone SYNOV4009298.
AY092062 - Homo sapiens breast cancer antigen 111717 mRNA, partial sequence.
BC111059 - Homo sapiens KLRAQ motif containing 1, mRNA (cDNA clone MGC:111781 IMAGE:5745902), complete cds.
AK307755 - Homo sapiens cDNA, FLJ97703.
BC143466 - Homo sapiens KLRAQ motif containing 1, mRNA (cDNA clone MGC:176991 IMAGE:9051974), complete cds.
BC117279 - Homo sapiens KLRAQ motif containing 1, mRNA (cDNA clone MGC:150888 IMAGE:40125830), complete cds.
BC143463 - Homo sapiens KLRAQ motif containing 1, mRNA (cDNA clone MGC:176988 IMAGE:9051971), complete cds.
JD420327 - Sequence 401351 from Patent EP1572962.
BC040721 - Homo sapiens KLRAQ motif containing 1, mRNA (cDNA clone IMAGE:6062607), complete cds.
JD337036 - Sequence 318060 from Patent EP1572962.
JD144871 - Sequence 125895 from Patent EP1572962.
KJ895456 - Synthetic construct Homo sapiens clone ccsbBroadEn_04850 PPP1R21 gene, encodes complete protein.
KJ903748 - Synthetic construct Homo sapiens clone ccsbBroadEn_13142 PPP1R21 gene, encodes complete protein.
AK172753 - Homo sapiens cDNA FLJ23914 fis, clone CAS01989.
BC011978 - Homo sapiens KLRAQ motif containing 1, mRNA (cDNA clone IMAGE:3865164), partial cds.
JD466886 - Sequence 447910 from Patent EP1572962.
JD279708 - Sequence 260732 from Patent EP1572962.
JD556911 - Sequence 537935 from Patent EP1572962.
JD069242 - Sequence 50266 from Patent EP1572962.
JD143151 - Sequence 124175 from Patent EP1572962.
JD493531 - Sequence 474555 from Patent EP1572962.
JD437044 - Sequence 418068 from Patent EP1572962.
JD203359 - Sequence 184383 from Patent EP1572962.
JD563019 - Sequence 544043 from Patent EP1572962.
JD418997 - Sequence 400021 from Patent EP1572962.
JD533442 - Sequence 514466 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: CCDC128, KLRAQ1, NM_001193475, NP_001180404, Q6ZMI0-5
UCSC ID: uc010yok.2
RefSeq Accession: NM_001193475
Protein: Q6ZMI0-5, splice isoform of Q6ZMI0 CCDS: CCDS1839.1, CCDS54358.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001193475.1
exon count: 20CDS single in 3' UTR: no RNA size: 3055
ORF size: 2217CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4634.00frame shift in genome: no % Coverage: 99.84
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.