Human Gene FARP2 (uc010zor.2) Description and Page Index
  Description: Homo sapiens FERM, RhoGEF and pleckstrin domain protein 2 (FARP2), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr2:242,295,664-242,405,445 Size: 109,782 Total Exon Count: 18 Strand: +
Coding Region
   Position: hg19 chr2:242,312,523-242,404,925 Size: 92,403 Coding Exon Count: 17 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr2:242,295,664-242,405,445)mRNA (may differ from genome)Protein (647 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
PubMedReactomeStanford SOURCETreefamUniProtKBWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): FARP2
CDC HuGE Published Literature: FARP2
Positive Disease Associations: Chronic lymphocytic leukemia , Leukemia, Lymphocytic, Chronic, B-Cell
Related Studies:
  1. Chronic lymphocytic leukemia
    Crowther-Swanepoel ,et al. 2010, Common variants at 2q37.3, 8q24.21, 15q21.3 abd 16q24.1 influence chronic lymphocytic leukemia risk, Nature genetics 2010 42- 2 : 132-6. [PubMed 20062064]
  2. Leukemia, Lymphocytic, Chronic, B-Cell
    Dalemari Crowther-Swanepoel et al. Nature genetics 2010, Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk., Nature genetics. [PubMed 20062064]

-  MalaCards Disease Associations
  MalaCards Gene Search: FARP2
Diseases sorted by gene-association score: pseudohypoparathyroidism ia (7)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.87 RPKM in Testis
Total median expression: 142.80 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -81.70164-0.498 Picture PostScript Text
3' UTR -151.96520-0.292 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00373 - FERM central domain
PF00621 - RhoGEF domain
PF08736 - FERM adjacent (FA)
PF09379 - FERM N-terminal domain
PF09380 - FERM C-terminal PH-like domain

SCOP Domains:
47031 - Second domain of FERM
48065 - DBL homology domain (DH-domain)
49723 - Lipase/lipooxygenase domain (PLAT/LH2 domain)
50729 - PH domain-like
54236 - Ubiquitin-like

ModBase Predicted Comparative 3D Structure on O94887-2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Descriptions from all associated GenBank mRNAs
  AK300435 - Homo sapiens cDNA FLJ61617 complete cds, highly similar to FERM, RhoGEF and pleckstrin domain-containing protein 2.
AB018336 - Homo sapiens KIAA0793 mRNA for KIAA0793 protein.
BC021301 - Homo sapiens FERM, RhoGEF and pleckstrin domain protein 2, mRNA (cDNA clone MGC:29593 IMAGE:5013180), complete cds.
JF432117 - Synthetic construct Homo sapiens clone IMAGE:100073256 FERM, RhoGEF and pleckstrin domain protein 2 (FARP2) gene, encodes complete protein.
CU676916 - Synthetic construct Homo sapiens gateway clone IMAGE:100018384 5' read FARP2 mRNA.
KJ902031 - Synthetic construct Homo sapiens clone ccsbBroadEn_11425 FARP2 gene, encodes complete protein.
JD141708 - Sequence 122732 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04520 - Adherens junction

Reactome (by CSHL, EBI, and GO)

Protein O94887 (Reactome details) participates in the following event(s):

R-HSA-399936 Inhibition of integrin activation by sequestering PIP5KIgamma
R-HSA-399942 Plexin-A1-4 binds NRP1
R-HSA-399933 Sema3A binds Nrp-1 bound to PlexinA
R-HSA-399938 Activation of Rac1 by FARP2
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-HSA-373755 Semaphorin interactions
R-HSA-422475 Axon guidance
R-HSA-1266738 Developmental Biology

-  Other Names for This Gene
  Alternate Gene Symbols: BC021301, KIAA0793, NM_014808, NP_055623, O94887-2, PLEKHC3
UCSC ID: uc010zor.2
RefSeq Accession: NM_014808
Protein: O94887-2, splice isoform of O94887 CCDS: CCDS63197.1, CCDS63198.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: BC021301.2
exon count: 18CDS single in 3' UTR: no RNA size: 2596
ORF size: 1944CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4027.00frame shift in genome: no % Coverage: 99.38
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.