Human Gene PLK1S1 (uc010zsi.2) Description and Page Index
Description: Homo sapiens polo-like kinase 1 substrate 1 (PLK1S1), transcript variant 3, mRNA. RefSeq Summary (NM_001163023): The protein encoded by this gene localizes to centrosomes, strengthening and stabilizing the pericentriolar region prior to spindle formation. The encoded protein usually remains with the mother centrosome after centrosomal duplication. Sevral transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.304899.1, AK293166.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## Transcript (Including UTRs) Position: hg19 chr20:21,106,624-21,227,258 Size: 120,635 Total Exon Count: 12 Strand: + Coding Region Position: hg19 chr20:21,112,795-21,227,214 Size: 114,420 Coding Exon Count: 11
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on Q2M2Z5-5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.