Human Gene CCND3 (uc011dum.1) Description and Page Index
  Description: Homo sapiens cyclin D3 (CCND3), transcript variant 1, mRNA.
RefSeq Summary (NM_001136017): The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].
Transcript (Including UTRs)
   Position: hg19 chr6:41,904,522-42,016,610 Size: 112,089 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr6:41,904,920-41,908,278 Size: 3,359 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr6:41,904,522-42,016,610)mRNA (may differ from genome)Protein (127 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
PubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=cDNA FLJ57763, highly similar to G1/S-specific cyclin-D3;
SIMILARITY: Belongs to the cyclin family.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CCND3
CDC HuGE Published Literature: CCND3
Positive Disease Associations: Body Fat Distribution , Body Mass Index , Body Weight , Erythrocyte Count , Erythrocyte Indices , hematological parameters , mean corpuscular hemoglobin , mean corpuscular volume , Neutrophils , Waist Circumference , Waist-Hip Ratio
Related Studies:
  1. Body Fat Distribution
    , , . [PubMed 0]
  2. Body Fat Distribution
    , , . [PubMed 0]
  3. Body Mass Index
    , , . [PubMed 0]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: CCND3
Diseases sorted by gene-association score: bladder carcinoma in situ (22), b-cell lymphomas (21), retinoblastoma (13), burkitt lymphoma (8), gliosarcoma (7), multiple myeloma (7), mantle cell lymphoma (5), reticulosarcoma (5), retinal cancer (5), sensory system cancer (4), fructose intolerance, hereditary (4), breast cancer (3), lymphoma, non-hodgkin (2), chronic lymphocytic leukemia (2), ocular cancer (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 77.11 RPKM in Whole Blood
Total median expression: 902.87 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -207.10417-0.497 Picture PostScript Text
3' UTR -130.26398-0.327 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013763 - Cyclin-like
IPR006671 - Cyclin_N

Pfam Domains:
PF00134 - Cyclin, N-terminal domain

SCOP Domains:
47954 - Cyclin-like

ModBase Predicted Comparative 3D Structure on B4E0N5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0007049 cell cycle

-  Descriptions from all associated GenBank mRNAs
  AK096276 - Homo sapiens cDNA FLJ38957 fis, clone NT2RI2000128, highly similar to G1/S-specific cyclin-D3.
AB209825 - Homo sapiens mRNA for cyclin D3 variant protein.
AK057206 - Homo sapiens cDNA FLJ32644 fis, clone SYNOV2001239, highly similar to G1/S-specific cyclin-D3.
AK097856 - Homo sapiens cDNA FLJ40537 fis, clone THYMU1000109, highly similar to G1/S-SPECIFIC CYCLIN D3.
AK303452 - Homo sapiens cDNA FLJ57763 complete cds, highly similar to G1/S-specific cyclin-D3.
BC011616 - Homo sapiens cyclin D3, mRNA (cDNA clone MGC:10400 IMAGE:3946312), complete cds.
M92287 - Homo sapiens cyclin D3 (CCND3) mRNA, complete cds.
AK055519 - Homo sapiens cDNA FLJ30957 fis, clone HCASM2000214, highly similar to G1/S-specific cyclin-D3.
M90814 - Human D3-type cyclin (CCND3) mRNA, complete cds.
CR542246 - Homo sapiens full open reading frame cDNA clone RZPDo834C0326D for gene CCND3, cyclin D3; complete cds, incl. stopcodon.
DQ891748 - Synthetic construct clone IMAGE:100004378; FLH181632.01X; RZPDo839F06136D cyclin D3 (CCND3) gene, encodes complete protein.
AK315421 - Homo sapiens cDNA, FLJ96475, Homo sapiens cyclin D3 (CCND3), mRNA.
KJ890843 - Synthetic construct Homo sapiens clone ccsbBroadEn_00237 CCND3 gene, encodes complete protein.
DQ895130 - Synthetic construct Homo sapiens clone IMAGE:100009590; FLH181628.01L; RZPDo839F06135D cyclin D3 (CCND3) gene, encodes complete protein.
AB385206 - Synthetic construct DNA, clone: pF1KB9359, Homo sapiens CCND3 gene for G1/S-specific cyclin-D3, complete cds, without stop codon, in Flexi system.
AK299187 - Homo sapiens cDNA FLJ58934 complete cds, moderately similar to G1/S-specific cyclin-D3.
LF212989 - JP 2014500723-A/20492: Polycomb-Associated Non-Coding RNAs.
MA448566 - JP 2018138019-A/20492: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04110 - Cell cycle
hsa04115 - p53 signaling pathway
hsa04310 - Wnt signaling pathway
hsa04510 - Focal adhesion
hsa04630 - Jak-STAT signaling pathway

BioCarta from NCI Cancer Genome Anatomy Project
h_cellcyclePathway - Cyclins and Cell Cycle Regulation

-  Other Names for This Gene
  Alternate Gene Symbols: AK303452, B4E0N5, B4E0N5_HUMAN, NM_001136017, NP_001129489
UCSC ID: uc011dum.1
RefSeq Accession: NM_001136017
Protein: B4E0N5

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: AK303452.1
exon count: 3CDS single in 3' UTR: no RNA size: 932
ORF size: 384CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 790.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 451# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.