Human Gene ITIH5 (uc021pmu.1) Description and Page Index
  Description: Homo sapiens inter-alpha-trypsin inhibitor heavy chain family, member 5 (ITIH5), transcript variant 2, mRNA.
RefSeq Summary (NM_032817): This gene encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor (ITI) family members. ITI proteins are involved in extracellular matrix stabilization and in the prevention of tumor metastasis. They are also structurally related plasma serine protease inhibitors and are composed of a light chain and varying numbers of heavy chains. This family member is thought to function as a tumor suppressor in breast and thyroid cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011].
Transcript (Including UTRs)
   Position: hg19 chr10:7,601,232-7,661,636 Size: 60,405 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr10:7,605,045-7,661,553 Size: 56,509 Coding Exon Count: 11 

Page IndexSequence and LinksGenetic AssociationsCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated: 2013-06-15

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr10:7,601,232-7,661,636)mRNA (may differ from genome)Protein (728 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
OMIMPubMedStanford SOURCETreefamUniProtKB

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): ITIH5
CDC HuGE Published Literature: ITIH5
Positive Disease Associations: Body Height , Myocardial Infarction , Oocytes
Related Studies:
  1. Body Height
    , , . [PubMed 0]
  2. Body Height
    , , . [PubMed 0]
  3. Myocardial Infarction
    , , . [PubMed 0]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 41.24 RPKM in Adipose - Subcutaneous
Total median expression: 359.46 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -17.5083-0.211 Picture PostScript Text
3' UTR -1259.543813-0.330 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF00092 - von Willebrand factor type A domain
PF06668 - Inter-alpha-trypsin inhibitor heavy chain C-terminus
PF13519 - von Willebrand factor type A domain
PF13768 - von Willebrand factor type A domain

SCOP Domains:
53300 - vWA-like

ModBase Predicted Comparative 3D Structure on Q86UX2-3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Descriptions from all associated GenBank mRNAs
  BC050649 - Homo sapiens inter-alpha (globulin) inhibitor H5, mRNA (cDNA clone IMAGE:6149028).
AY358426 - Homo sapiens clone DNA44192 LLLL311 (UNQ311) mRNA, complete cds.
AK027547 - Homo sapiens cDNA FLJ14641 fis, clone NT2RP2001467.
BC069714 - Homo sapiens cDNA clone IMAGE:7262598.
JD059758 - Sequence 40782 from Patent EP1572962.
JD381567 - Sequence 362591 from Patent EP1572962.
JD189787 - Sequence 170811 from Patent EP1572962.
JD405253 - Sequence 386277 from Patent EP1572962.
JD057160 - Sequence 38184 from Patent EP1572962.
JD100417 - Sequence 81441 from Patent EP1572962.
JD246689 - Sequence 227713 from Patent EP1572962.
JD084172 - Sequence 65196 from Patent EP1572962.
JD182641 - Sequence 163665 from Patent EP1572962.
JD331854 - Sequence 312878 from Patent EP1572962.
JD435826 - Sequence 416850 from Patent EP1572962.
JD118721 - Sequence 99745 from Patent EP1572962.
JD475993 - Sequence 457017 from Patent EP1572962.
JD561338 - Sequence 542362 from Patent EP1572962.
JD481344 - Sequence 462368 from Patent EP1572962.
JD429636 - Sequence 410660 from Patent EP1572962.
JD531002 - Sequence 512026 from Patent EP1572962.
JD274292 - Sequence 255316 from Patent EP1572962.
JD114064 - Sequence 95088 from Patent EP1572962.
JD221759 - Sequence 202783 from Patent EP1572962.
JD221763 - Sequence 202787 from Patent EP1572962.
JD190850 - Sequence 171874 from Patent EP1572962.
JD454783 - Sequence 435807 from Patent EP1572962.
JD430068 - Sequence 411092 from Patent EP1572962.
JD356918 - Sequence 337942 from Patent EP1572962.
JD434559 - Sequence 415583 from Patent EP1572962.
JD048344 - Sequence 29368 from Patent EP1572962.
JD156028 - Sequence 137052 from Patent EP1572962.
JD101612 - Sequence 82636 from Patent EP1572962.
DQ580599 - Homo sapiens piRNA piR-48711, complete sequence.
JD393741 - Sequence 374765 from Patent EP1572962.
JD391177 - Sequence 372201 from Patent EP1572962.
JD067910 - Sequence 48934 from Patent EP1572962.
JD288912 - Sequence 269936 from Patent EP1572962.
JD201200 - Sequence 182224 from Patent EP1572962.
JD459797 - Sequence 440821 from Patent EP1572962.
BC136439 - Homo sapiens cDNA clone IMAGE:9020428.
JD175301 - Sequence 156325 from Patent EP1572962.
JD492610 - Sequence 473634 from Patent EP1572962.
JD203059 - Sequence 184083 from Patent EP1572962.
JD552026 - Sequence 533050 from Patent EP1572962.
JD408181 - Sequence 389205 from Patent EP1572962.
JD203640 - Sequence 184664 from Patent EP1572962.
JD339262 - Sequence 320286 from Patent EP1572962.
JD229375 - Sequence 210399 from Patent EP1572962.
JD303784 - Sequence 284808 from Patent EP1572962.
BC004282 - Homo sapiens cDNA clone IMAGE:3616602, containing frame-shift errors.
BC142961 - Homo sapiens cDNA clone IMAGE:8860371, containing frame-shift errors.
AB075833 - Homo sapiens mRNA for KIAA1953 protein.
AL833203 - Homo sapiens mRNA; cDNA DKFZp667H186 (from clone DKFZp667H186).
AK075381 - Homo sapiens cDNA PSEC0071 fis, clone NT2RP2002115, highly similar to Inter-alpha trypsin inhibitor heavy chain precursor 5.
JD322284 - Sequence 303308 from Patent EP1572962.
JD376254 - Sequence 357278 from Patent EP1572962.
JD566755 - Sequence 547779 from Patent EP1572962.
JD195669 - Sequence 176693 from Patent EP1572962.
AK027375 - Homo sapiens cDNA FLJ14469 fis, clone MAMMA1000897, weakly similar to INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H3 PRECURSOR.
JD077116 - Sequence 58140 from Patent EP1572962.
JD422730 - Sequence 403754 from Patent EP1572962.
JD060083 - Sequence 41107 from Patent EP1572962.
JD093879 - Sequence 74903 from Patent EP1572962.
JD094453 - Sequence 75477 from Patent EP1572962.
JD310383 - Sequence 291407 from Patent EP1572962.
JD161980 - Sequence 143004 from Patent EP1572962.
JD437335 - Sequence 418359 from Patent EP1572962.
JD377336 - Sequence 358360 from Patent EP1572962.
JD081203 - Sequence 62227 from Patent EP1572962.
AY238437 - Homo sapiens inter-alpha trypsin inhibitor heavy chain precursor 5 (ITIH5) mRNA, complete cds.
BC167770 - Synthetic construct Homo sapiens clone IMAGE:100068160, MGC:195777 inter-alpha (globulin) inhibitor H5 (ITIH5) mRNA, encodes complete protein.
KJ899651 - Synthetic construct Homo sapiens clone ccsbBroadEn_09045 ITIH5 gene, encodes complete protein.
AB384652 - Synthetic construct DNA, clone: pF1KA1953, Homo sapiens ITIH5 gene for inter-alpha trypsin inhibitor heavy chain precursor 5 isoform 1, complete cds, without stop codon, in Flexi system.
AK027831 - Homo sapiens cDNA FLJ14925 fis, clone PLACE1008643, weakly similar to INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H2 PRECURSOR.
AK027849 - Homo sapiens cDNA FLJ14943 fis, clone PLACE1011371, weakly similar to INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H2 PRECURSOR.
KJ906335 - Synthetic construct Homo sapiens clone ccsbBroadEn_16005 ITIH5 gene, encodes complete protein.
CR627109 - Homo sapiens mRNA; cDNA DKFZp686F0145 (from clone DKFZp686F0145).
AF318347 - Homo sapiens pp14776 mRNA, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: KIAA1953, NM_032817, NP_116206, PP14776, Q86UX2-3, UNQ311/PRO354
UCSC ID: uc021pmu.1
RefSeq Accession: NM_032817
Protein: Q86UX2-3

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_032817.5
exon count: 10CDS single in 3' UTR: no RNA size: 6100
ORF size: 2188CDS single in intron: no Alignment % ID: 99.98
txCdsPredict score: 4343.00frame shift in genome: yes % Coverage: 99.72
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.