Human Gene ITIH5 (uc021pmu.1) Description and Page Index
Description: Homo sapiens inter-alpha-trypsin inhibitor heavy chain family, member 5 (ITIH5), transcript variant 2, mRNA. RefSeq Summary (NM_032817): This gene encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor (ITI) family members. ITI proteins are involved in extracellular matrix stabilization and in the prevention of tumor metastasis. They are also structurally related plasma serine protease inhibitors and are composed of a light chain and varying numbers of heavy chains. This family member is thought to function as a tumor suppressor in breast and thyroid cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]. Transcript (Including UTRs) Position: hg19 chr10:7,601,232-7,661,636 Size: 60,405 Total Exon Count: 11 Strand: - Coding Region Position: hg19 chr10:7,605,045-7,661,553 Size: 56,509 Coding Exon Count: 11
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00092 - von Willebrand factor type A domain PF06668 - Inter-alpha-trypsin inhibitor heavy chain C-terminus PF13519 - von Willebrand factor type A domain PF13768 - von Willebrand factor type A domain
ModBase Predicted Comparative 3D Structure on Q86UX2-3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.